1990
DOI: 10.1002/cne.902950106
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Synapses formed by olivocochlear axon branches in the mouse cochlear nucleus

Abstract: Cochlear nucleus branches of thick olivocochlear axons were labeled by injections of horseradish peroxidase into the spiral ganglion of the cochlear basal turn in mice. Six labeled axons were traced by light microscopy, and selected portions of seven branches were sectioned serially for electron microscopic examination. Axonal branches most frequently terminated near certain granule cell regions of the ventral cochlear nucleus. This article describes terminals, synapses, and postsynaptic elements of these oliv… Show more

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Cited by 104 publications
(117 citation statements)
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“…Methods for our injections and processing appear in previous publications (Brown et al 1988b;Benson and Brown 1990). All experimental procedures on animals were in accordance with the National Institutes of Health guidelines for the care and use of laboratory animals and were performed under approved protocols at the Massachusetts Eye & Ear Infirmary.…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Methods for our injections and processing appear in previous publications (Brown et al 1988b;Benson and Brown 1990). All experimental procedures on animals were in accordance with the National Institutes of Health guidelines for the care and use of laboratory animals and were performed under approved protocols at the Massachusetts Eye & Ear Infirmary.…”
Section: Methodsmentioning
confidence: 99%
“…The cochlear nucleus was blocked, embedded in a mixture of gelatin and albumin (0.5% and 27%, respectively) that was hardened by the addition of glutaraldehyde (2.3% of total volume), and sectioned (50 lm thickness) on a Vibratome in the sagittal plane. Free-floating sections were processed to reveal the HRP reaction product within the labeled fibers (Fekete et al 1984;Brown et al 1988b;Benson and Brown 1990) using diaminobenzidine as the chromogen and adding 1% dimethylsulfoxide to solutions containing cobalt or diaminobenzidine. After postfixation in 1% osmium tetroxide for 15 min, the sections were stained en bloc with saturated, filtered uranyl acetate (1 h), dehydrated with methanol, infiltrated with epoxy, and flatembedded between two transparent sheets of Aclar (Pro Plastics, Wall, NJ).…”
Section: Methodsmentioning
confidence: 99%
“…As in all branches, the initial portion of the branch is thin. Then, the branch increases in diameter and forms frequent swellings, which have been demonstrated to be sites where they form synapses (Benson Brown 1990). In terms of the number of swellings per length and the shapes of the swellings, the terminal morphology of the branches in the knockout did not obviously differ between strains.…”
Section: Brown and Vetter: Moc Neurons In α9 Knockout Micementioning
confidence: 99%
“…The endings of these branches contain round synaptic vesicles and form asymmetric synapses (Benson and Brown 1990), suggesting that they have an excitatory effect. During OC feedback to the periphery, the branches may compensate for reduced sensitivity of the cochlea by increasing the responses of certain neurons in the cochlear nucleus (Benson and Brown 1990). This type of compensation could theoretically be important in neurons that code for the absolute intensity of a sound.…”
Section: Oc Collateral Branches To the Cochlear Nucleusmentioning
confidence: 99%
“…The inhibition is suspected to arise from glycinergic D-stellate neurons that also reside in the VCN (Doucet and Ryugo 2006;Ferragamo et al 1998). Tract-tracing studies have identified these large multipolar cells as the target of collateral projections from the medial olivocochlear system (Benson and Brown 1990). This descending pathway has been proposed as a feedback system for attenuating cochlear amplification at high sound pressure levels and restoring the lost gain by disinhibiting the chopper response.…”
Section: Physiological Studies Of Loudness Recruitmentmentioning
confidence: 99%