Synaptic Ménage à Trois

Furlanis, Elisabetta; Scheiffele, Peter

doi:10.1016/j.neuron.2016.05.007

Cited by 1 publication

(1 citation statement)

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“…C1q interacts directly with myelin associated glycoprotein in myelin, which results in the reduction of growth inhibitory signalling in neurons . Expression levels of C1q are dramatically increased in the ageing mouse and human brain, and C1q‐deficient mice exhibit enhanced synaptic plasticity in the adult and reorganization of the circuitry in the dentate gyrus of aged hippocampus …”

Section: Introductionmentioning

confidence: 99%

Transient increase of microglial C1q expression in the circumventricular organs of adult mouse during LPS‐induced inflammation

Kawai

Kurganov

Miyata

2020

Cell Biochemistry & Function

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The circumventricular organs (CVOs) are the brain regions that lack the blood-brain barrier and allow free entry of blood-derived molecules, offering specialized niche to initiate rapid and early neuroinflammatory responses in the brain. Complement component 1q (C1q) is shown to be the first recognition component of the complement pathway and has a crucial function in the brain under pathological conditions. In the present study, we found that C1q expression in CX3CR1-positive microglia was increased in the CVOs and their neighbouring brain regions of adult mice at 1 day after a single administration of 1 mg/kg lipopolysaccharide (LPS), whereas it returned to control levels at 3 days after LPS stimulation. C1q expression was also seen to localize at synapsin-positive presynaptic axonal terminals in various brain regions. Thus, the present study demonstrates a transient upregulation of microglial C1q expression in the CVOs and their adjacent brain regions, indicating that a transient upregulation of C1q is possibly concerned with physiological responses at early phase of brain inflammation.Significance of the Study: The circumventricular organs (CVOs) are specialized brain regions that lack the blood-brain barrier (BBB) and initiate neuroinflammatory responses in the brains. The present study showed that the expression of complement protein C1q was highly increased in microglia of the CVOs and their adjacent brain regions. Moreover, C1q expression was observed to localize specifically at presynaptic axonal terminals in the CVOs and their neighbouring brain regions. Thus, the present study indicates that C1q is possibly correlated with physiological responses at early phase of brain inflammation. K E Y W O R D Sbrain, complement pathway, immunohistochemistry, inflammation, microglia

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Section: Introductionmentioning

confidence: 99%