Synaptic pattern of AMPA receptor subtypes upon direction-selective retinal ganglion cells

Jeong, Shinkyu; Kwon, Oh-Ju; Lee, Jea-Young; Kim, Tae-Jin; Jeon, Chang‐Jin

doi:10.1016/j.neures.2006.08.011

Cited by 13 publications

(24 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AMPA Receptor Subunits in the Outer Retina. Although the GluR1 subunit is predominately expressed in the dendrites of the OFF-cone bipolar cells in cat and rodent retinas, 55,63 previous studies have indicated that GluR1 expresses weakly in the OPL of the adult rabbit retina, 38 which is consistent with our immunostaining results (Fig. 1B).…”

Section: Expression Of Ampa Receptor Subunits In the Developing Retinasupporting

confidence: 92%

“…The expression pattern of GluR2/3 in the developing rabbit retina is similar to that in the developing rat retina, though the immunostaining in both the IPL and OPL was detected earlier in rabbits. [15][16][17] The fact that the immunoreactivity of GluR2/3 shows two bands in the IPL throughout the developmental stages implies that GluR2/3 is expressed early in both cholinergic amacrine cells 38,44 and AII amacrine cells, 35,37 which is similar to the adult rabbit retina.…”

Section: Expression Of Ampa Receptor Subunits In the Developing Rabbimentioning

confidence: 80%

“…Although the expression of GluR2/3 and -R4 was stronger than that of GluR1 in the OPL of adult retinas (Figs. 1F, 1J), 38 the phenomenon of a transient increase in GluR2/3 and -R4 expression in the OPL from P2 to P8 (Figs. 3, 4) was similar to the expression pattern for GluR1 in the developing retina.…”

Section: Expression Of Ampa Receptor Subunits In the Developing Retinamentioning

confidence: 96%

“…35,[37][38][39][40] To confirm their expression patterns in the retinal slices, antibodies against the AMPA subunits were used to characterize their localizations in the retinal layers. Figure 1 shows confocal images of double-labeling of the AMPA subunits GluR1, -R2/3, or -R4 (red) and calretinin (green).…”

Section: Expression Of Ampa Receptor Subunits In the Adult Rabbit Retinamentioning

confidence: 99%

See 3 more Smart Citations

Localization and Functional Mapping of AMPA Receptor Subunits in the Developing Rabbit Retina

Chang

Chiao

2008

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

Section: Expression Of Ampa Receptor Subunits In the Developing Retinasupporting

confidence: 92%

Section: Expression Of Ampa Receptor Subunits In the Developing Rabbimentioning

confidence: 80%

Section: Expression Of Ampa Receptor Subunits In the Developing Retinamentioning

confidence: 96%

Section: Expression Of Ampa Receptor Subunits In the Adult Rabbit Retinamentioning

confidence: 99%

See 2 more Smart Citations

Localization and Functional Mapping of AMPA Receptor Subunits in the Developing Rabbit Retina

Chang

Chiao

2008

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…To elucidate whether inhibition occurs postsynaptically, various receptors or receptor subtypes need to be mapped onto morphologically and physiologically identified DSGCs, using a combination of electrophysiological recording, intracellular injection and receptor immunohistochemistry. Jeon and colleagues [54,55,65] accomplished such experiments by using a triple-labeling technique. They provided conclusive micropharmacological evidence of random distribution of both nicotinic cholinergic and glutamatergic receptors on dendrites of DSGCs.…”

Section: The Road To the Presynaptic Model Underlying Direction Selecmentioning

confidence: 99%

Cellular Inhibitory Behavior Underlying the Formation of Retinal Direction Selectivity in the Starburst Network

Poznański¹

2010

J. Integr. Neurosci.

View full text Add to dashboard Cite

Optical imaging of dendritic calcium signals provided evidence of starburst amacrine cells exhibiting calcium bias to somatofugal motion. In contrast, it has been impractical to use a dual-patch clamp technique to record membrane potentials from both proximal dendrites and distal varicosities of starburst amacrine cells in order to unequivocally prove that they are directionally sensitive to voltage, as was first suggested almost two decades ago. This paper aims to extend the passive cable model to an active cable model of a starburst amacrine cell that is intrinsically dependent on the electrical properties of starburst amacrine cells, whose various macroscopic currents are described quantitatively. The coupling between voltage and calcium just below the membrane results in a voltage-calcium system of coupled nonlinear Volterra integral equations whose solutions must be integrated into a prescribed model for example, for a synaptic couplet of starburst amacrine cells. Networks of starburst amacrine cells play a fundamental role in the retinal circuitry underlying directional selectivity. It is suggested that the dendritic plexus of starburst amacrine cells provides the substrate for the property of directional selectivity, while directional selectivity is a property of the exclusive layerings and confinement of their interconnections within the sublaminae of the inner plexiform layer involving cone bipolar cells and directionally selective ganglion cells.

show abstract

Different types of ganglion cell share a synaptic pattern

Vasudeva

Vardi

et al. 2008

J of Comparative Neurology

View full text Add to dashboard Cite

Retinal ganglion cells comprise about 10 morphological types that also differ functionally. To determine whether functional differences might arise partially from differences in excitatory input, we quantified the distributions of ribbon contacts to four mammalian ganglion cell types [brisk-transient (BT), brisk-sustained (BS), local edge (LE), directionally selective (DS)], comparing small vs. large and "sluggish" vs. "brisk." Cells in guinea pig retina were filled with fluorescent dye, immunostained for synaptic ribbons, and reconstructed with their ribbon contacts by confocal microscopy. False-positive contacts were corrected by performing the same analysis on processes that lack synapses: glial stalks and rod bipolar axons. All types shared a domed distribution of membrane that was well fit by a Gaussian function (R(2) = 0.96 +/- 0.01); they also shared a constant density of contacts on the dendritic membrane, both across each arbor and across cell types (19 +/- 1 contacts/100 microm(2) membrane). However, the distributions of membrane across the retina differed markedly in width (BT > DS approximately BS > LE) and peak density (BS > DS > LE > BT). Correspondingly, types differed in peak density of contacts (BS > DS approximately LE > BT) and total number (BS approximately BT > DS > LE). These differences between cell types in spatial extent and local concentration of membrane and synapses help to explain certain functional differences.

show abstract

Synaptic pattern of AMPA receptor subtypes upon direction-selective retinal ganglion cells

Cited by 13 publications

References 44 publications

Localization and Functional Mapping of AMPA Receptor Subunits in the Developing Rabbit Retina

Localization and Functional Mapping of AMPA Receptor Subunits in the Developing Rabbit Retina

Cellular Inhibitory Behavior Underlying the Formation of Retinal Direction Selectivity in the Starburst Network

Different types of ganglion cell share a synaptic pattern

Contact Info

Product

Resources

About