Synaptic Plasticity Depends on the Fine-Scale Input Pattern in Thin Dendrites of CA1 Pyramidal Neurons

Magó, Ádám; Weber, Jens P.; Ujfalussy, Balázs; Makara, Judit K.

doi:10.1523/jneurosci.2071-19.2020

Cited by 26 publications

(36 citation statements)

References 54 publications

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“…The functional organization of excitatory input that we observed (Fig. 4 ) is also consistent with local learning rules strengthening local subsets of synapses to store memories, through LTP 4 , 9 , 10 , 12 , 13 , 40 , 53 – 57 , intracellular signaling 11 , 58 , 59 , or genetically defined clustered wiring 34 , 50 and is seemingly more difficult to explain using only global plasticity mechanisms 7 , 8 , 60 – 62 . Finally, since context-specificity and global remapping drive much of the interest in place coding, future studies should aim to determine how the synaptic input properties described here change during place field formation.…”

Section: Discussionsupporting

confidence: 81%

The functional organization of excitatory synaptic input to place cells

et al. 2021

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Hippocampal place cells contribute to mammalian spatial navigation and memory formation. Numerous models have been proposed to explain the location-specific firing of this cognitive representation, but the pattern of excitatory synaptic input leading to place firing is unknown, leaving no synaptic-scale explanation of place coding. Here we used resonant scanning two-photon microscopy to establish the pattern of synaptic glutamate input received by CA1 place cells in behaving mice. During traversals of the somatic place field, we found increased excitatory dendritic input, mainly arising from inputs with spatial tuning overlapping the somatic field, and functional clustering of this input along the dendrites over ~10 µm. These results implicate increases in total excitatory input and co-activation of anatomically clustered synaptic input in place firing. Since they largely inherit their fields from upstream synaptic partners with similar fields, many CA1 place cells appear to be part of multi-brain-region cell assemblies forming representations of specific locations.

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Section: Discussionsupporting

confidence: 81%

The functional organization of excitatory synaptic input to place cells

et al. 2021

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“…Synaptic plasticity is affected by a number of factors, including the state of the synapse, Ca2+ concentration, local potential of the dendritic membrane, etc. Given the fact that synaptic plasticity can occur locally in dendrites without the involvement of somatic output, the state of the dendritic tree is extremely important for the information storage processes [ 42 ]. Thus, in our study, the normal level of hippocampal synaptic plasticity may be based on the maintenance of the CA1-pyramidal neurons’ dendritic tree structure.…”

Section: Discussionmentioning

confidence: 99%

N-Docosahexanoylethanolamine Reduces Microglial Activation and Improves Hippocampal Plasticity in a Murine Model of Neuroinflammation

Tyrtyshnaia

Bondar

Konovalova

et al. 2020

IJMS

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Chronic neuroinflammation is a common pathogenetic link in the development of various neurological and neurodegenerative diseases. Thus, a detailed study of neuroinflammation and the development of drugs that reduce or eliminate the negative effect of neuroinflammation on cognitive processes are among the top priorities of modern neurobiology. N-docosahexanoylethanolamine (DHEA, synaptamide) is an endogenous metabolite and structural analog of anandamide, an essential endocannabinoid produced from arachidonic acid. Our study aims to elucidate the pharmacological activity of synaptamide in lipopolysaccharide (LPS)-induced neuroinflammation. Memory deficits in animals were determined using behavioral tests. To study the effects of LPS (750 µg/kg/day, 7 days) and synaptamide (10 mg/kg/day, 7 days) on synaptic plasticity, long-term potentiation was examined in the CA1 area of acute hippocampal slices. The Golgi–Cox method allowed us to assess neuronal morphology. The production of inflammatory factors and receptors was assessed using ELISA and immunohistochemistry. During the study, functional, structural, and plastic changes within the hippocampus were identified. We found a beneficial effect of synaptamide on hippocampal synaptic plasticity and morphological characteristics of neurons. Synaptamide treatment recovered hippocampal neurogenesis, suppressed microglial activation, and significantly improved hippocampus-dependent memory. The basis of the phenomena described above is probably the powerful anti-inflammatory activity of synaptamide, as shown in our study and several previous works.

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“…Initiation and maintenance of LTP are associated with an increase in dendritic branching. Increasing the receptive surface of neurons contributes to the strengthening of excitatory transmission in pyramidal neurons of the CA1 area [21,22].…”

Section: Discussionmentioning

confidence: 99%

Reactivity of astrocytes in hippocampal CA1 area in rats after administration of habanero peppers

Jaworska-Adamu

Krawczyk

Rycerz

et al. 2021

Folia Histochem Cytobiol.

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Introduction. Astrocytes react to microenvironmental changes. Their reactivity is manifested by an increase in glial fibrillary acidic protein (GFAP) and S100β protein levels, hypertrophy and hyperplasia. The aim of the study was to analyse immunoreactive GFAP (GFAP-IR) and S100β (S100β-IR) astrocytes of hippocampal CA1 area in adult rats intragastrically (i.g.) treated with habanero peppers.Material and methods. Brains from 10 control rats (group C) and 10 rats receiving oil suspension of habanero fruits for 7 days (group I-7) or 28 days (group II-28) were used.Antibodies against GFAP and S100β were used for immunohistochemistry. Morphology and distribution of astrocytes was evaluated under light microscope and their density was quantitatively analysed.Results. In the CA1 hippocampal area of group II-28 rats, GFAP-IR cells with numerous, branched processes were observed. S100β-IR astrocytes had delicate, single processes in comparison with cells without processes observed in groups I-7 and C. In groups I-7 and II-28, GFAP-IR astrocytes' density significantly increased in SR -stratum radiatum of hippocampal CA1 area. In group I-7, a density of cells with the expression of S100β was significantly increased in SO -stratum oriens layer. In group II-28, the density of S100β-IR astrocytes was decreased. Conclusions.Habanero peppers administrated to rats, especially for a longer time, caused reactive changes in the astrocytes in hippocampal CA1 area, and thus these glial cells may protect neurons against excitotoxic damage.

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Synaptic Plasticity Depends on the Fine-Scale Input Pattern in Thin Dendrites of CA1 Pyramidal Neurons

Cited by 26 publications

References 54 publications

The functional organization of excitatory synaptic input to place cells

The functional organization of excitatory synaptic input to place cells

N-Docosahexanoylethanolamine Reduces Microglial Activation and Improves Hippocampal Plasticity in a Murine Model of Neuroinflammation

Reactivity of astrocytes in hippocampal CA1 area in rats after administration of habanero peppers

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