Synbiotic Effect of Whole Grape Seed Flour and Newly Isolated Kefir Lactic Acid Bacteria on Intestinal Microbiota of Diet-Induced Obese Mice

Seo, Kyung Jin; Kim, Dong Hyeon; Yokoyama, Wallace; Kim, Hyun‐Sook

doi:10.1021/acs.jafc.0c01240

Cited by 16 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…What scientists found was an increased F/B ratio in obese versus lean samples (Moran‐Ramos et al, 2017). Also, LAB that can alleviate obesity generally reduces the F/B ratio and raise the diversity of gut microbiota (K. H. Seo et al, 2020). L. plantarum LC27 were reported to alleviate obesity in mice with the effect of reducing Firmicutes and Proteobacteria abundance in gut microbiota and lipopolysaccharide (LPS) production (In Kim et al, 2019).…”

Section: Effects Of Lab Intervention On Gut Microbiota Results In Wei...mentioning

confidence: 99%

Advances in the role and mechanism of lactic acid bacteria in treating obesity

Shen

Zhang

Yang

et al. 2022

Food Bioengineering

View full text Add to dashboard Cite

Obesity and its related complications have become increasingly serious social problems that threaten people's lives. Lactic acid bacteria (LAB) have shown an effective influence on preventing obesity in animal experiments and human clinical trials, but its exact mechanism remains unclear. In this review, LAB and several of its metabolites are taken as the point of penetration. It is aimed to summarize the relationship between obesity and gut microbiota, the efficacy of LAB, and its potential mechanisms of preventing obesity and lipid metabolism. LAB intervention can regulate gut microbiota and improve intestinal permeability which is damaged by a high-fat diet or lipopolysaccharide. Besides this, some metabolites produced by LAB can be involved in regulating host lipid metabolism-related pathways. Short-chain fatty acids, linoleic acid, and gammaaminobutyric acid, taken as representatives here, can participate in the regulation through AMP-activated protein kinase or peroxisome proliferator-activated receptor pathway and bowel-brain axis. Therefore, the ingestion of LAB may become a potential adjunctive treatment for obesity in future.

show abstract

Section: Effects Of Lab Intervention On Gut Microbiota Results In Wei...mentioning

confidence: 99%

Advances in the role and mechanism of lactic acid bacteria in treating obesity

Shen

Zhang

Yang

et al. 2022

Food Bioengineering

View full text Add to dashboard Cite

show abstract

“…In contrast, the richness of microflora severely decreased after treatment with kanamycin, the Chao1 index decreased from 957.83 to 355.77, and the Shannon index decreased from 4.92 to 4.23. The results indicated that oral antibiotics for 3 days significantly decreased the diversity of intestinal microflora in mice, whereas d -Au NPs cannot affect the richness and evenness of intestinal microflora [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

Plasmon-Enhanced Antibacterial Activity of Chiral Gold Nanoparticles and In Vivo Therapeutic Effect

Wang

Zhang

et al. 2021

Nanomaterials

View full text Add to dashboard Cite

d-cysteine (d-cys) has been demonstrated to possess an extraordinary antibacterial activity because of its unique steric configuration. However, inefficient antibacterial properties seriously hinder its wide applications. Here, cysteine-functionalized gold nanoparticles (d-/l-Au NPs) were prepared by loading d-/l-cysteine on the surface of gold nanoparticles for the effective inhibition of Escherichia coli (E. coli) in vitro and in vivo, and the effects on the intestinal microflora in mice were explored during the treatment of E. coli infection in the gut. We found that the antibacterial activity of d-/l-Au NPs was more than 2–3 times higher than pure d-cysteine, l-cysteine and Au NPs. Compared with l-Au NPs, d-Au NPs showed the stronger antibacterial activity, which was related to its unique steric configuration. Chiral Au NPs showed stronger destructive effects on cell membrane compared to other groups, which further leads to the leakage of the cytoplasm and bacterial cell death. The in vivo antibacterial experiment illustrated that d-Au NPs displayed impressive antibacterial activity in the treatment of E. coli-infected mice comparable to kanamycin, whereas they could not affect the balance of intestinal microflora. This work is of great significance in the development of an effective chiral antibacterial agent.

show abstract

“…Our previous study demonstrated that the consumption of 5% kefiran (EPS extracted from kefir grain) prevented high fat-induced obesity in an animal model [ 29 ], which was associated with the modulation of intestinal microbiota. L. kefiri DH5 (LKDH5) and L. mesenteroides 4 (LMDH04) used for present animal study showed the greatest inhibitory pancreatic lipase activity [ 33 ]. Tannin polyphenols enriched in GSF have an inhibitory pancreatic lipase activity [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Synergistic Effects of Heat-Killed Kefir Paraprobiotics and Flavonoid-Rich Prebiotics on Western Diet-Induced Obesity

2020

Self Cite

View full text Add to dashboard Cite

The synergistic anti-obesity effect of paraprobiotic heat-killed lactic acid bacteria (HLAB) and prebiotics has not been studied. To determine the anti-obesity properties of prebiotic polyphenol-rich wine grape seed flour (GSF) and paraprobiotic HLAB, C57BL/6J mice were administered a high-fat and high-fructose diet (HFFrD) with 5% microcrystalline cellulose (CON), HFFrD supplemented with 2.5% GSF, HFFrD with orally administered HLAB, or HFFrD with a combination of GSF and orally administered HLAB (GSF+HLAB) for 8 weeks. Compared with the CON group, the GSF and HLAB groups both showed significant reductions in HFFrD-induced body weight gain and adipose tissue weights (p < 0.05). Interestingly, combined supplementation with GSF and HLAB revealed statistically significant synergistic effects on body weight gain, visceral adiposity, and plasma triacylglycerol concentrations (p < 0.05). The synergistic action was significantly related to a decreased adipocyte gene expression in fatty acid synthesis and inflammation metabolism. In conclusion, the combination of prebiotic GSF and paraprobiotic kefir HLAB is potentially useful, as natural food ingredients, in the prevention of obesity and obesity-related diseases, especially for immunocompromised individuals.

show abstract

Synbiotic Effect of Whole Grape Seed Flour and Newly Isolated Kefir Lactic Acid Bacteria on Intestinal Microbiota of Diet-Induced Obese Mice

Cited by 16 publications

References 43 publications

Advances in the role and mechanism of lactic acid bacteria in treating obesity

Advances in the role and mechanism of lactic acid bacteria in treating obesity

Plasmon-Enhanced Antibacterial Activity of Chiral Gold Nanoparticles and In Vivo Therapeutic Effect

Synergistic Effects of Heat-Killed Kefir Paraprobiotics and Flavonoid-Rich Prebiotics on Western Diet-Induced Obesity

Contact Info

Product

Resources

About