Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis

Abstract

Enfermedad renal crónica. Microbiota. Simbióticos. Diarrea. Hemodiálisis. Key words:Chronic kidney disease. Microbiota. Synbiotics. Diarrhea. Hemodialysis. ResumenIntroducción: los pacientes con enfermedad renal crónica (ERC) a menudo tienen síntomas gastrointestinales que pueden provocar desnutrición y un impacto negativo en su calidad de vida. La modulación de la microbiota intestinal puede ser una estrategia para promover la salud del huésped y la homeostasis. Caso clínico: los autores presentan un caso de diarrea crónica de etiología desconocida en un paciente en hemodiálisis (HD). Después de varias intervenciones fallidas durante un año, se realizó el tratamiento simbiótico. Los episodios de diarrea cesaron después de tres meses de la suplementación diaria y ambos parámetros bioquímicos y nutricionales mejoraron. La terapia con simbióticos promovió beneficios clínicos para este paciente. Discusión: por lo tanto, esta sencilla terapia puede ser una alternativa prometedora en la ERC y debe ser probada en estudios más amplios.Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis AbstractBackground: Chronic kidney disease (CKD) patients often have gastrointestinal symptoms which may result in malnutrition and a negative impact on their quality of life. Modulation of the gut microbiota can be a strategy to promote host health and homeostasis. Case report: The authors present a case of chronic diarrhea in a hemodialysis (HD) patient with an unknown etiology. After about one year and several failed interventions, synbiotic therapy was performed. The diarrhea episodes ceased after three months of daily supplementation and both biochemical and nutritional parameters improved. Synbyotic therapy promoted clinical benefits in this patient. Discussion: Therefore, this simple therapy may be a promising alternative in CKD and it should be tested in larger studies.

Biotic Supplements for Renal Patients: A Systematic Review and Meta-Analysis

“…In patients undergoing chronic peritoneal- or hemo-dialysis, positive correlations have been found between lipopolysaccharides from gut bacteria and C-reactive protein levels [ 46 , 47 ] and subclinical endotoxemia has recently been acknowledged as a relevant cause for inflammation in patients with CKD [ 48 , 49 ]. Biotic administration may also improve the pro-inflammatory status of CKD patients [ 50 ]. Our systematic literature search retrieved a considerable number of RCTs ( n = 13) testing the effects of biotic supplements on inflammatory markers in renal patients.…”