2021
DOI: 10.1007/s00294-021-01214-y
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Synchronisation of glycolytic activity in yeast cells

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Cited by 11 publications
(10 citation statements)
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“…Specifically, recent studies on the synchronization among phase oscillators coupled with a coupling strength γ that can be mapped to ε in the present study, have also shown enlarged Arnold tongues with increasing γ [51], indicating the enhanced stability of oscillatory dynamics or chronotaxicity , in other words the ability of a self-sustained oscillator to resist non-autonomous perturbations. Along with these studies [51,52], our study substantiates that the glycolytic oscillation of a single cell can indeed be influenced by the oscillatory metabolic signals from the surrounding cells, and explains the ease of inter-cellular synchronization and enhanced stability of oscillations in cell populations [50,53,54]. However, an excessive amount of glucose injection can bring the system into disarray, rendering the dynamical state of the system chaotic, in other words, hyper-sensitive to initial conditions and unpredictable.…”
Section: Discussionsupporting
confidence: 79%
“…Specifically, recent studies on the synchronization among phase oscillators coupled with a coupling strength γ that can be mapped to ε in the present study, have also shown enlarged Arnold tongues with increasing γ [51], indicating the enhanced stability of oscillatory dynamics or chronotaxicity , in other words the ability of a self-sustained oscillator to resist non-autonomous perturbations. Along with these studies [51,52], our study substantiates that the glycolytic oscillation of a single cell can indeed be influenced by the oscillatory metabolic signals from the surrounding cells, and explains the ease of inter-cellular synchronization and enhanced stability of oscillations in cell populations [50,53,54]. However, an excessive amount of glucose injection can bring the system into disarray, rendering the dynamical state of the system chaotic, in other words, hyper-sensitive to initial conditions and unpredictable.…”
Section: Discussionsupporting
confidence: 79%
“…Glycolytic oscillations are typically induced in yeast by exposure of starved cells to glucose combined with cyanide, although weaker and less sustained oscillations could also be induced by glucose alone 32 , 71 , and they primarily originate due to the allosteric regulation of PFK 18 , 27 , 28 , 30 . However, whether such glycolytic oscillations are common and physiologically significant remains unclear 26 , 33 .…”
Section: Discussionmentioning
confidence: 99%
“…Glycolytic oscillations were observed in other eukaryotic cells, too [23][24][25] . It was proposed that this oscillatory process is controlled primarily by allosteric regulation of phosphofructokinase, with substrate inhibition by ATP and product activation by AMP and fructose 1,6-bisphosphate 18,20,[26][27][28][29][30] , though additional interactions might be involved in regulation of such oscillations and their synchronization between individual cells 21,[31][32][33][34][35][36] . Although glycolytic oscillations were also predicted to occur in prokaryotes [37][38][39] , the only experimental indication for their existence in bacteria was up to now provided by early measurements of metabolite dynamics in the Escherichia coli bioreactor culture exposed to glucose 40 .…”
mentioning
confidence: 99%
“…Enhancement of the harmonic and sub/super-harmonic entrainments of glycolytic oscillation under the weak-to-medium periodic drivings is manifested as the broadening of the entrainment bands . This finding sub-stantiates that the glycolytic oscillation of a single cell can indeed be influenced by the oscillatory metabolic signals from the surrounding cells, and explains the ease of inter-cellular synchronization and enhanced oscillations in cell populations [4648]. However, an excessive amount of glucose injection can bring the system into disarray, rendering the dynamical state of the system chaotic, in other words, hyper-sensitive to initial conditions and inherently uncontrollable.…”
Section: Discussionmentioning
confidence: 92%