Generalized projective lag synchronization (GPLS) is characterized by the output of the drive system proportionally lagging behind the output of the response system. In this paper, GPLS between different hyperchaotic systems with uncertain parameters, i.e., GPLS between Lorenz and Lü hyperchaotic systems, and between Lorenz-Stenflo and Lorenz hyperchaotic systems, is studied by applying an adaptive control method. Based on Lyapunov stability theory, the adaptive controllers and corresponding parameter update rules are constructed to make the states of two diverse hyperchaotic systems asymptotically synchronize up to the desired scaling matrix and to estimate the uncertain parameters. Some numerical simulations are provided to show the effectiveness of our results.