Synchronization of estrus in virgin beef heifers using melengestrol acetate and PGF2α: an efficacy comparison of cloprostenol and dinoprost tromethamine

Salverson, R. R.; DeJarnette, J.M.; Marshall, C.E.; Wallace, R. A.

doi:10.1016/s0093-691x(01)00692-6

Cited by 15 publications

(10 citation statements)

References 9 publications

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“…Cairoli et al (2006) found no differences in conception rates between cloprostenol and dinoprost in cows inseminated at observed oestrus. In agreement with the findings of the present study, Salverson et al (2002) reported that following administration of PGF 2α (dinoprost and racemic cloprostenol) in combination with MGA, the oestrus synchronisation and fertility results were similar for the two prostaglandins.…”

Section: Discussionsupporting

confidence: 93%

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Marı́n

Sánchez

Vizuete

et al. 2015

Acta Veterinaria Hungarica

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This trial evaluated the reproductive performance in an early routine oestrus induction programme using two different PGF 2α preparations in dairy cattle. D-cloprostenol sodium (n = 192; Group A) or dinoprost (n = 187; Group B) was administered between days 35 and 42 post partum. Also, a group of non-treated cows (n = 135; Group C) was included as control. Pedometers were used to detect oestrus, and also secondary oestrous signs and vaginal mucus quality were assessed prior to artificial insemination (AI). When oestrus was not detected for 14 days after PGF 2α administration, the treatment was repeated, up to a maximum of three times. There were no differences between the study groups in oestrus detection (A = 73.48%, B = 73.01%, C = 79.26%; P = 0.428), good mucus quality (A = 96.45%, B = 91.30%, C = 93.45%; P = 0.203) and the presence of mounting lesions (A = 98.58, B = 94.93%, C = 98.13; P = 0.414). First-service pregnancy rates were 19.78%, 15.64% and 32.03% in Groups A, B and C, respectively (P = 0.003). There were no inter-group differences for the interval from parturition to first AI. However, a significantly shorter interval from parturition to conception (92.17 days, 99.45 days, 118.93 days; P = 0.002) and significantly less services per conception (2.12, 2.18, 2.66; P = 0.003) were observed in Groups A and B in comparison with Group C. The use of PGF 2α resulted in better fertility in a repetitive, routine postpartum programme, although no differences between Dcloprostenol and dinoprost were detected.

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Section: Discussionsupporting

confidence: 93%

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Marı́n

Sánchez

Vizuete

et al. 2015

Acta Veterinaria Hungarica

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“…Mondal et al collected luteal tissue from Angus crossbred heifers 4 h after giving an intramuscular injection of 25 mg Lutalyse at day 11 of the estrous cycle. Shah et al treated non-lactating Bubalus bubalis (water buffalo) cows with a 500 mg dose of Juramate (equivalent to 25 mg of Lutalyse (Salverson et al, 2002)) and collected luteal tissue at 6 h after PGF2a. The overlap of differentially expressed transcripts between the three datasets is visually represented in a Venn diagram in Fig.…”

Section: Dataset Comparisonsmentioning

confidence: 99%

Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling

Talbott

Hou

Qiu

et al. 2017

Molecular and Cellular Endocrinology

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In ruminants, prostaglandin F2alpha (PGF2α)-mediated luteolysis is essential prior to estrous cycle resumption, and is a target for improving fertility. To deduce early PGF2α-provoked changes in the corpus luteum a short time-course (0.5-4 h) was performed on cows at midcycle. A microarray-determined transcriptome was established and examined by bioinformatic pathway analysis. Classic PGF2α effects were evident by changes in early response genes (FOS, JUN, ATF3) and prediction of active pathways (PKC, MAPK). Several cytokine transcripts were elevated and NF-κB and STAT activation were predicted by pathway analysis. Self-organizing map analysis grouped differentially expressed transcripts into ten mRNA expression patterns indicative of temporal signaling cascades. Comparison with two analogous datasets revealed a conserved group of 124 transcripts similarly altered by PGF2α treatment, which both, directly and indirectly, indicated cytokine activation. Elevated levels of cytokine transcripts after PGF2α and predicted activation of cytokine pathways implicate inflammatory reactions early in PGF2α-mediated luteolysis.

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“…The total percentage of heifers observed in estrus throughout the detection period was also similar between treatment groups (P = 0.40) and is comparable to results of a 5-mL i.m. injection of dinoprost tromethamine previously reported (Salverson et al, 2002). Beef heifers administered with dinoprost tromethamine s.c. had similar mean intervals to estrus and rates of ovulation to heifers administered i.m.…”

Section: Methodsmentioning

confidence: 99%

“…Numerous studies have evaluated the effectiveness of various PGF 2α products. No differences were reported between the ability of different PGF 2α products to decrease progesterone concentrations (Schams and Karg, 1982;Guay et al, 1988) or induce an estrus response (Plata et al, 1990;Martineau, 2003), and have shown no differences in pregnancy rates (Salverson et al, 2002;Stevenson & Phatak, 2010). The route of PGF 2α administration also had no effect on the decline in progesterone concentration, nor on the proportion of cows undergoing luteal regression (Chebel et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Comparison of two alternate PGF2α products in two estrus synchronization protocols in beef heifers

Oosthuizen

Lansford²,

Canal

et al. 2018

Journal of Animal Science

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Two experiments were conducted to evaluate the effects of a high concentrate, s.c. PGF2α compared with a conventionally concentrated, i.m. PGF2α in estrus synchronization protocols for heifers. In Exp. 1, 869 Angus-based beef heifers were enrolled at 8 locations. All heifers were exposed to the 7-d CO-Synch + controlled internal drug release (CIDR) estrus synchronization protocol. On day 7 of the protocol heifers received 100 µg of GnRH i.m., and a CIDR insert for 7 d. On day 0, at CIDR removal, estrous detection patches were applied to heifers and, within location, heifers randomly received 1 of 2 PGF2α treatments: 5 mL of Lutalyse i.m. (CONTROL; n = 434) or a 2 mL of Lutalyse HighCon s.c. (HiCON; n = 435). A second GnRH injection was administered at 54 ± 2 h and heifers were fixed-time AI (TAI). Heifers were evaluated for estrous activity at TAI by determining the activation of estrous detection patches. Pregnancy rates to AI (PR/AI) were diagnosed by transrectal ultrasonography between 35 and 55 d after TAI. The percentage of heifers exhibiting estrus between day 0 and TAI did not differ (P = 0.68) between CONTROL and HiCON treatments (47 vs. 46 ± 4%, respectively). Additionally, PR/AI were similar (P = 0.65) between CONTROL and HiCON treatments (46 vs. 45 ± 3%). In Exp. 2, 190 Angus-based beef heifers were enrolled at 2 locations. Heifers were exposed to the melengestrol acetate (MGA)-PGF2α protocol where they were offered 0.5 mg MGA per day from days 1 to 14. On day 33, heifers were randomly assigned to receive CONTROL (n = 95) or HiCON (n = 95) treatment, and estrous detection aids were applied. Heifers were exposed to AI 12 h after detection of estrus. Heifers not detected in estrus at location 1 received a second PGF2α injection 6 d after the initial PGF2α injection and were placed with fertile bulls. Heifers at location 2 that did not express estrus were administered 100 µg of GnRH i.m. and exposed to TAI 96 h after the initial PGF2α injection. Transrectal ultrasonography was used to diagnose PR/AI between 51 and 57 d after the initial PGF2α injection. The percentage of heifers exhibiting estrus during the estrus detection period was similar (P = 0.40) between CONTROL and HiCON treatments (82 vs. 87 ± 4%). Furthermore, PR/AI were similar (P = 0.62) between CONTROL and HiCON treatments (60 vs. 65 ± 5%). In summary, the 2 concentrations and corresponding routes of administration of PGF2α were similar in efficacy at synchronizing estrus in beef heifers.

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Synchronization of estrus in virgin beef heifers using melengestrol acetate and PGF2α: an efficacy comparison of cloprostenol and dinoprost tromethamine

Cited by 15 publications

References 9 publications

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Oestrus synchronisation in postpartum dairy cows using repetitive prostaglandin doses: Comparison between D-cloprostenol and dinoprost

Early transcriptome responses of the bovine midcycle corpus luteum to prostaglandin F2α includes cytokine signaling

Comparison of two alternate PGF2α products in two estrus synchronization protocols in beef heifers

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