Synchronized neuronal oscillations and their role in motor processes

MacKay, William A.

doi:10.1016/s1364-6613(97)01059-0

Cited by 167 publications

(110 citation statements)

References 37 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…It is well known that the maintenance of sustained motor output is severely impaired when somatosensory input is lacking (35)(36)(37). Thus, it seems reasonable that the modulation of motor cortex by primary somatosensory cortex reported here depends on ongoing input from the periphery, an explanation that is compatible with the existence of a sensorimotor loop through the periphery (19,38). The results further suggest that the cortical portion of this loop is part of a more extensive network that includes the inferior posterior parietal cortex (Fig.…”

Section: Discussionsupporting

confidence: 68%

“…This article addresses the functional relations between beta oscillations in pre-and postcentral cortical areas in premovement motor maintenance behavior. It has long been proposed that behavior of this type depends on a corticoperipheral cortical sensorimotor loop (17,18), and more recently that this loop is supported by oscillatory neuronal activity (19). Reports of beta oscillations in both somatosensory and motor cortices during premovement maintenance behavior (3,5,6,9), taken together with recent studies proposing that beta rhythms are uniquely suited for synchronization over long conduction delays (20,21), thus suggest the hypothesis that beta oscillations provide a mechanism that binds sensory and motor cortical areas into a functioning loop.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Beta oscillations in a large-scale sensorimotor cortical network: Directional influences revealed by Granger causality

Brovelli

Ding

Ledberg

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

992

910

View full text Add to dashboard Cite

Previous studies have shown that synchronized beta frequency (14 -30 Hz) oscillations in the primary motor cortex are involved in maintaining steady contractions of contralateral arm and hand muscles. However, little is known about the role of postcentral cortical areas in motor maintenance and their patterns of interaction with motor cortex. We investigated the functional relations of beta-synchronized neuronal assemblies in pre-and postcentral areas of two monkeys as they pressed a hand lever during the wait period of a visual discrimination task. By using power and coherence spectral analysis, we identified a beta-synchronized largescale network linking pre-and postcentral areas. We then used Granger causality spectra to measure directional influences among recording sites. In both monkeys, strong Granger causal influences were observed from primary somatosensory cortex to both motor cortex and inferior posterior parietal cortex, with the latter area also exerting Granger causal influences on motor cortex. Granger causal influences from motor cortex to postcentral sites, however, were weak in one monkey and not observed in the other. These results are the first, to our knowledge, to demonstrate in awake monkeys that synchronized beta oscillations bind multiple sensorimotor areas into a large-scale network during motor maintenance behavior and carry Granger causal influences from primary somatosensory and inferior posterior parietal cortices to motor cortex.cerebral cortex ͉ motor maintenance ͉ parietal ͉ local field potential ͉ coherence O scillatory activity in the beta frequency range (14-30 Hz) is widely observed in sensorimotor cortex in relation to motor behavior in both humans (1, 2) and nonhuman primates (3-6). Specifically, beta oscillations in monkeys appear in local field potential (LFP) and spiking activity during tactile exploratory forelimb movements (4, 7, 8), movement preparation (5, 6, 9), and steady-state isometric contractions (10). Beta oscillatory activity is often observed to be synchronized between different parts of sensorimotor cortex (4,5,7,(9)(10)(11), between motor cortical LFPs and descending pyramidal tract neuron discharge (10, 12), between single motor units (13,14), and between motor cortical activity and muscle activity (1,4,10,12,15,16).Although the role of beta oscillations in the outflow of activity from motor cortex to muscles is relatively well characterized for certain types of behavior, the relation of beta oscillations in postcentral areas and motor cortex remains poorly understood. This article addresses the functional relations between beta oscillations in pre-and postcentral cortical areas in premovement motor maintenance behavior. It has long been proposed that behavior of this type depends on a corticoperipheral cortical sensorimotor loop (17, 18), and more recently that this loop is supported by oscillatory neuronal activity (19). Reports of beta oscillations in both somatosensory and motor cortices during premovement maintenance behavior (3, 5, 6, 9), taken toge...

show abstract

Section: Discussionsupporting

confidence: 68%

mentioning

confidence: 99%

Beta oscillations in a large-scale sensorimotor cortical network: Directional influences revealed by Granger causality

Brovelli

Ding

Ledberg

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

992

910

View full text Add to dashboard Cite

show abstract

“…Neuronal activity in the ␥-band is associated with normal motor function (MacKay, 1997;Brown et al, 2001Brown et al, , 2002Cassidy et al, 2002). Its presence in our model provides considerable evidence that the model captures many functional properties of the healthy BG.…”

Section: Predictions Of the Modelmentioning

confidence: 62%

“…oscillations have been found in local-field potential (LFP) recordings in the BG of both awake and anesthetized animals, including humans (Brown et al, 2001;Berke et al, 2004;Magill et al, 2004b). Their absence in the BG of Parkinson's disease patients (Brown et al, 2001) and increase in power during motor activity Cassidy et al, 2002) suggests that ␥-band oscillations are intimately related to normal motor behavior (MacKay, 1997). However, despite the anatomically identified feedback loop formed between STN and GP, the two nuclei seem decoupled in the healthy BG (Magill et al, 2000;Raz et al, 2000;Urbain et al, 2000;Baufreton et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia

Humphries

Stewart²,

Gurney³

2006

J. Neurosci.

341

439

View full text Add to dashboard Cite

The basal ganglia (BG) have long been implicated in both motor function and dysfunction. It has been proposed that the BG form a centralized action selection circuit, resolving conflict between multiple neural systems competing for access to the final common motor pathway. We present a new spiking neuron model of the BG circuitry to test this proposal, incorporating all major features and many physiologically plausible details. We include the following: effects of dopamine in the subthalamic nucleus (STN) and globus pallidus (GP), transmission delays between neurons, and specific distributions of synaptic inputs over dendrites. All main parameters were derived from experimental studies. We find that the BG circuitry supports motor program selection and switching, which deteriorates under dopamine-depleted and dopamine-excessive conditions in a manner consistent with some pathologies associated with those dopamine states. We also validated the model against data describing oscillatory properties of BG. We find that the same model displayed detailed features of both ␥-band

show abstract

“…On the one hand, it has been proposed that spikes of multiple neurons are synchronized when individual features coded by such neurons belong to a common object (Gray, 1999;Singer, 1999;von der Malsburg, 1999). Similarly, synchronous spikes in the motor cortical areas have been proposed as a means to bind individual movement segments to produce complex movement patterns (Pfurtscheller et al, 1993;Murthy and Fetz, 1996a,b;MacKay, 1997;Riehle et al, 1997;Donoghue et al, 1998;Lebedev and Wise, 2000;Ohara et al, 2001;Baker et al, 2003). Experimental support for this hypothesis, unfortunately, has not been consistent (Lamme and Spekreijse, 1998;Thiele and Stoner, 2003).…”

Section: Introductionmentioning

confidence: 99%

Behavioral Context and Coherent Oscillations in the Supplementary Motor Area

Lee¹

2004

J. Neurosci.

View full text Add to dashboard Cite

Movements with similar physical characteristics can occur in various behavioral contexts, as when they are embedded in different sequences or when the expected outcomes of movements vary. Similarly, neurons in various sensory and motor structures in the brain commonly display modulations in their activity according to contextual factors, such as expected reward. Although these contextual signals must be combined with incoming sensory inputs to generate appropriate behaviors according to the animal's motivational state, the mechanisms by which these two signals are integrated remain poorly understood. The present study examined the effects of contextual factors on the magnitude of coherent oscillations in the activity of individual neurons recorded in the supplementary motor area (SMA) of monkeys during a serial reaction time task. In this task, the animal produced a predictable sequence of hand movements repeatedly according to visual instructions. The performance of the animal was influenced by the location of the rewarded target as well as the ordinal position of the movement. In contrast, the level of coherent oscillations in the activity of SMA neurons was affected only by the rewarded target location but not by the ordinal position of the movement sequence. In addition, changes in coherent oscillations were not accounted for by systematic changes in the mean firing rates. These results are consistent with the proposal that synchronous spikes might be used to control the flow of information and suggest that coherent oscillations in the SMA might encode contextual variables, such as expected reward.

show abstract

Synchronized neuronal oscillations and their role in motor processes

Cited by 167 publications

References 37 publications

Beta oscillations in a large-scale sensorimotor cortical network: Directional influences revealed by Granger causality

Beta oscillations in a large-scale sensorimotor cortical network: Directional influences revealed by Granger causality

A Physiologically Plausible Model of Action Selection and Oscillatory Activity in the Basal Ganglia

Behavioral Context and Coherent Oscillations in the Supplementary Motor Area

Contact Info

Product

Resources

About