Synchronized Quartz Crystal Microbalance and Nanoplasmonic Sensing of Biomolecular Recognition Reactions

Dahlin, Andreas; Jönsson, Peter; Jonsson, Magnus P.; Schmid, Emanuel; Zhou, Ye; Höök, Fredrik

doi:10.1021/nn800254h

Cited by 59 publications

(57 citation statements)

References 40 publications

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“…QCM as a mass sensitive device is widely used for detecting very small mass changes of even less than a nanogram deposited on electrode surface [236]. Through surface modification of the electrodes with sensitive materials, QCM devices have been used as highly sensitive sensors for environmental monitoring, chemical and biochemical analysis due to their sensitive interface measurement capability [237,238]. Sauerbrey [239] first derived the mass-frequency shift relation for quartz crystal resonators as follows:…”

Section: Qcm Sensorsmentioning

confidence: 99%

Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets

Wang

Ding

Sun

et al. 2013

Progress in Materials Science

478

300

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a b s t r a c tSince 2006, a rapid development has been achieved in a subject area, so called electro-spinning/netting (ESN), which comprises the conventional electrospinning process and a unique electro-netting process. Electronetting overcomes the bottleneck problem of electrospinning technique and provides a versatile method for generating spider-web-like nanonets with ultrafine fiber diameter less than 20 nm. Nano-nets, supported by the conventional electrospun nanofibers in the nano-fiber/nets (NFN) membranes, exhibit numerious attractive characteristics such as extremely small diameter, high porosity, and Steiner tree network geometry, which make NFN membranes optimal candidates for many significant applications. The progress made during the last few years in the field of ESN is highlighted in this review, with particular emphasis on results obtained in the author's research units. After a brief description of the development of the electrospinning and ESN techniques, several fundamental properties of NFN nanomaterials are addressed. Subsequently, the used polymers and the state-of-the-art strategies for the controllable fabrication of NFN membranes are highlighted in terms of the ESN process. Additionally, we highlight some potential applications associated with the remarkable features of NFN nanostructure. Our discussion is concluded with some personal perspectives on the future development in which this wonderful technique could be pursued.

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Section: Qcm Sensorsmentioning

confidence: 99%

Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets

Wang

Ding

Sun

et al. 2013

Progress in Materials Science

478

300

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“…The small sensing volume of plasmonic structures is also of interest for studying molecular conformations 5, 6. Since plasmonic sensing requires simply an optical transmission spectrum, or only the transmitted intensity at one or a few wavelengths, such a sensing setup can be readily incorporated with other sensor principles 7, 8. Some particularly useful biosensing features of nanohole arrays are that liquid can be transported through the surface9 and that single objects can be immobilized inside holes by size exclusion 10…”

Section: Introductionmentioning

confidence: 99%

Investigation of Plasmon Resonances in Metal Films with Nanohole Arrays for Biosensing Applications

Sannomiya

Scholder

Jefimovs

et al. 2011

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Biosensing with nanoholes is one of the most promising applications of nanoplasmonic devices. The sensor properties, however, are complex due to coupled resonances through propagating and localized surface plasmons. This Full Paper demonstrates experimental and simulation studies on different plasmonic hole systems, namely various patterns of circular holes in gold films. In contrast to most previous work, here, the challenging situation of optically thin films is considered. The refractive-index-sensing properties, such as sensitive locations in the nanostructure and sensitive spectral features, are investigated. The multiple multipole program provides the complete field distribution in the nanostructure for different wavelengths. It is shown that the spectral feature most sensitive to refractive-index changes is the extinction minimum, rather than the maximum. The results are consistent with theory for perfect electrical conductors. The spectral response is investigated for molecular adsorption at different positions inside or outside a hole. Furthermore, the optical properties of nanohole arrays with long-range and short-range order are compared and found to demonstrate remarkable similarities. Our results help to predict the resonance wavelengths of nanoholes with arbitrary patterns, including short-range order. The results presented here are highly important since they extend and challenge several aspects of the current understanding of plasmon resonances in nanohole arrays. These theoretical models, simulation results, and experimental data together help provide the understanding necessary for the development of efficient biomolecular analysis tools based on metallic nanoholes.

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“…Such combinations of sensor concepts are likely to provide the extraction of additional information about the studied systems that is not accessible with the single techniques alone. We recently developed a combination of the LSPR method with the QCM-D monitoring, 88,94 which relied on the fact that a plasmon active short-range ordered nanohole surface can be used as one of the electrodes of a QCM crystal. To form a supported lipid bilayer on the surface, the same structure as described above was used ͑ϳ20 nm SiO x sputtered on the short-range ordered gold nanoholes͒.…”

Section: Combined Nanoplasmonic and Quartz Crystal Microbalance Sementioning

confidence: 99%

Nanoplasmonic biosensing with focus on short-range ordered nanoholes in thin metal films (Review)

et al. 2008

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The resonance conditions for excitation of propagating surface plasmons at planar metal/dielectric interfaces and localized surface plasmons associated with metal nanostructures are both sensitive to changes in the interfacial refractive index. This has made these phenomena increasingly popular as transducer principles in label-free sensing of biomolecular recognition reactions. In this article, the authors review the recent progress in the field of nanoplasmonic bioanalytical sensing in general, but set particular focus on certain unique possibilities provided by short-range ordered nanoholes in thin metal films. Although the latter structures are formed in continuous metal films, while nanoparticles are discrete entities, these two systems display striking similarities with respect to sensing capabilities, including bulk sensitivities, and the localization of the electromagnetic fields. In contrast, periodic arrays of nanoholes formed in metal films, most known for their ability to provide wavelength-tuned enhanced transmission, show more similarities with conventional propagating surface plasmon resonance. However, common for both short-range ordered and periodic nanoholes formed in metal films is that the substrate is electrically conductive. Some of the possibilities that emerge from sensor templates that are both electrically conductive and plasmon active are discussed and illustrated using recent results on synchronized nanoplasmonic and quartz crystal microbalance with dissipation monitoring of supported lipid bilayer formation and subsequent biomolecular recognition reactions. Besides the fact that this combination of techniques provides an independent measure of biomolecular structural changes, it is also shown to contribute with a general means to quantify the response from nanoplasmonic sensors in terms of bound molecular mass.

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Synchronized Quartz Crystal Microbalance and Nanoplasmonic Sensing of Biomolecular Recognition Reactions

Cited by 59 publications

References 40 publications

Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets

Electro-spinning/netting: A strategy for the fabrication of three-dimensional polymer nano-fiber/nets

Investigation of Plasmon Resonances in Metal Films with Nanohole Arrays for Biosensing Applications

Nanoplasmonic biosensing with focus on short-range ordered nanoholes in thin metal films (Review)

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