Synchronous adenocarcinoma and marginal zone B-cell lymphoma of the colon: a case report

Sahasrabudhe, Neil; Khirwadkar, Nitin; Prescott, Richard

doi:10.1016/j.mpdhp.2009.03.005

Cited by 8 publications

(12 citation statements)

References 11 publications

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“…Notably, 1 case of simultaneous stage i colon adenocarcinoma and marginal zone lymphoma has been reported. However, the patient in that report was treated by surgical resection of the colon alone and did not receive any further treatment for lymphoma 11 . It has been postulated that lymphoma might predispose the colon to adenocarcinoma because of altered immune function, allowing for cancerous cells to grow without surveillance.…”

Section: Discussionmentioning

confidence: 97%

“…Cornes and others [12][13][14] observed that, in coexisting tumours, adenocarcinomas occur either synchronously with or after a diagnosis of lymphoma in the intestinal tract, suggesting an association between those two cancer types. Nonetheless, the rarity of such cases prevents any firm establishment of a relationship between lymphomas and adenocarcinomas 11,15 .…”

Section: Discussionmentioning

confidence: 99%

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Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

et al. 2016

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Synchronous cancers of different primary origin are rare. Here, we describe the case of a patient with concomitant diagnoses of rectal adenocarcinoma and splenic marginal zone lymphoma (smzl).A 57-year-old woman initially presented with abdominal pain. Physical examination and computed tomography demonstrated massive splenomegaly, and a complete blood count revealed microcytic anemia and lymphopenia. During the subsequent evaluation, she presented with hematochezia, melena, and constipation, which prompted gastroenterology referral. Subsequent endoscopic rectal ultrasonography revealed a T3N1 moderately differentiated rectal adenocarcinoma, with computed tomography imaging of chest, abdomen, and pelvis confirming no metastasis. Thus, the cancer was classified as clinical stage T3N1M0, stage iii. Bone marrow biopsy confirmed co-existing marginal zone lymphoma, and with the clinical presentation of massive splenomegaly, a diagnosis of smzl was made.The patient's management was individually tailored for simultaneous optimal treatment of both conditions. Concurrent treatment with neoadjuvant rituximab and 5-fluorouracil chemotherapy, with external-beam radiation therapy to the pelvis, was administered, followed by surgery consisting of en bloc splenectomy and distal pancreatectomy, and low anterior resection. The patient completed a standard course of adjuvant folfox (fluorouracil-leucovorin-oxaliplatin) chemotherapy and has remained disease-free for 7 years.To our knowledge, this report is the first to specifically describe simultaneous diagnoses of locally advanced rectal cancer and smzl. We also describe the successful combined neoadjuvant treatment combination of 5-fluorouracil, rituximab, and pelvic radiation.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

et al. 2016

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“…Primary colon lymphoma is rare and accounts for 0.2–0.4% of all colonic tumors [ [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] ]. It is defined by DAWSON [ 8 ] according to strict criteria ( Table 1 ).…”

Section: Clinical Discussionmentioning

confidence: 99%

“…It is defined by DAWSON [ 8 ] according to strict criteria ( Table 1 ). Its synchronous association with an adenocarcinoma is exceptional and represents a diagnostic surprise [ [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] ].…”

Section: Clinical Discussionmentioning

confidence: 99%

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Synchronous adenocarcinoma and marginal zone B-cell lymphoma of the colon. A case report

Haddadi¹,

Touati²,

Graidia³

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance The association of colonic adenocarcinoma with lymphoma is a rare entity. The purpose of our presentation is to draw the attention of the endoscopist, and the surgeon, to the need to remove any suspicious lesions in the exploration for colorectal cancer. The pathologist should be warned about this association in the face of any unusual change in the lymphatic environment around an adenocarcinoma. In the slightest doubt, an immunohistochemistry (IHC) should be performed in order not to ignore this association. Case presentation A 77-year-old patient, who had adenocarcinoma of the right colic flexure, in whom a chance discovery of lymphoma was made intraoperatively. This combination was treated with chemotherapy targeting adenocarcinoma classified as pT4N1M0, ahead of the low-grade lymphoma malignancy. After two years, the patient presented with a recurrence as left lateral cervical lymphadenopathy and died in a picture of generalized paralysis. Clinical discussion Digestive lymphoma associated with adneocarcinoma is defined according to strict criteria according to DAWSON. It always precedes adenocarcinoma because it disrupts the subject's immunocompetence. His diagnosis is suspected when the lymphatic environment around the adenocarcinoma is disturbed. The confirmation is assured with the IHC. Treatment should target the most aggressive cancer. Conclusion The synchronous colonic occurrence of a MALT-type lymphoma and an adenocarcinoma is rare but possible. The pathologist must be alert to its existence. Treatment depends on the tumor stage of the adenocarcinoma but also on the lymphoma and its grade and any therapeutic decision should only be made in a multidisciplinary meeting.

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Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon

Shaheen

Guddati

2013

Med Oncol

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Mucosa-associated lymphoid tissue (MALT)-type lymphomas most commonly occur in the stomach and have been associated with Helicobacter pylori infection. However, MALT-type lymphoma of the colon is a rare entity. It commonly manifests with symptoms of weight loss, low-grade fever, constipation, melena, and hematochezia. Unlike gastric lymphoma, it is difficult to detect MALT-type lymphoma of the colon by imaging. Colonoscopy may reveal lesions whose biopsy most commonly shows abundant B lymphocytes. There is no universal immunohistochemistry profile for MALT-type lymphoma but CD 20 staining is commonly seen. Trisomies and translocations have been described and their presence has been correlated with treatment response. Due to the rarity of colonic MALT-type lymphoma, no standard guidelines are available for its management. It often occurs individually and rarely occurs simultaneously with concurrent colon adenocarcinoma. This case report describes the presentation and clinical course of a secondary MALT-type lymphoma in a patient who underwent colectomy for a prior colon adenocarcinoma.

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Synchronous adenocarcinoma and marginal zone B-cell lymphoma of the colon: a case report

Cited by 8 publications

References 11 publications

Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

Synchronous adenocarcinoma and marginal zone B-cell lymphoma of the colon. A case report

Secondary mucosa-associated lymphoid tissue (MALT) lymphoma of the colon

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