Synchronous adenocarcinoma of the gall bladder and pancreas in a young woman

Agarwal, Nitin; Kumar, Sunil; Sharma, Sonal

doi:10.7869/tg.2012.96

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…Synchronous tumors of the biliary system and pancreas are rare, with fewer than ten cases reported in the literature [6] , [7] , [8] , [9] , [10] , [11] , [12] . Notably, the majority of these cases were geographically confined to Asia and involved the head of the pancreas.…”

Section: Discussionmentioning

confidence: 99%

Multifocal pancreatobiliary malignancies: A diagnostic and therapeutic challenge

Khurram

Khamar

Husain

et al. 2021

Radiology Case Reports

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The synchronous presentation of multifocal pancreatobiliary tumors is a rare occurrence and can prove to be a significant diagnostic and therapeutic challenge. We describe the case of a 70-year-old female who presented with a 2-week history of jaundice, reduced appetite, and mild epigastric discomfort of insidious onset. Radiological evaluation with computed tomography and magnetic resonance imaging demonstrated features consistent with a hilar cholangiocarcinoma , also known as a Klatskin tumor, involving both the cystic duct and gallbladder neck. In addition to this, a pancreatic neoplasm with associated splenic vein occlusion and metastatic deposits in the liver and lung were identified. The patient was managed with percutaneous transhepatic external biliary drainage and stenting by interventional radiology. Cytology results from the brushings obtained from the aforementioned procedure were nondiagnostic. Core biopsies were performed of the pancreatic lesion; the histopathological results of which were in keeping with pancreatic ductal adenocarcinoma . The patient was scheduled for chemotherapy however unfortunately deteriorated clinically prior to commencement. This case highlights the diagnostic and management challenges of synchronous pancreatobiliary malignancies.

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Section: Discussionmentioning

confidence: 99%

Multifocal pancreatobiliary malignancies: A diagnostic and therapeutic challenge

Khurram

Khamar

Husain

et al. 2021

Radiology Case Reports

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“…A reasonable assumption indicates that chronic irritation of the mucosa leads to dysplasia and causes malignant changes[ 29 ]. Additionally, 62.5% of SPCs of the biliary tract have been reported to be associated with abnormal pancreaticobiliary junction (APBJ) caused by persistent reflux of pancreatic juice with subsequent biliary inflammation[ 30 - 32 ]. In our case, the cystic duct was too long and had low confluence with the common bile duct.…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary duodenal papillary adenocarcinoma and gallbladder carcinoma: A case report and review of literature

Chen¹,

Huang²,

Zhou³

et al. 2022

WJCC

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BACKGROUND Synchronous primary cancers (SPCs) have become increasingly frequent over the past decade. However, the coexistence of duodenal papillary and gallbladder cancers is rare, and such cases have not been previously reported in the English literature. Here, we describe an SPC case with duodenal papilla and gallbladder cancers and its diagnosis and successful management. CASE SUMMARY A 68-year-old Chinese man was admitted to our hospital with the chief complaint of dyspepsia for the past month. Contrast-enhanced computed tomography of the abdomen performed at the local hospital revealed dilatation of the bile and pancreatic ducts and a space-occupying lesion in the duodenal papilla. Endoscopy revealed a tumor protruding from the duodenal papilla. Pathological findings for the biopsied tissue revealed tubular villous growth with moderate heterogeneous hyperplasia. Surgical treatment was selected. Macroscopic examination of this surgical specimen revealed a 2-cm papillary tumor and another tumor protruding by 0.5 cm in the gallbladder neck duct. Intraoperative rapid pathology identified adenocarcinoma in the gallbladder neck duct and tubular villous adenoma with high-grade intraepithelial neoplasia and local canceration in the duodenal papilla. After an uneventful postoperative recovery, the patient was discharged without complications. CONCLUSION It is essential for clinicians and pathologists to maintain a high degree of suspicion while evaluating such synchronous cancers.

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“…The prognosis of metastatic gallbladder is poor, with a median survival of less than 12 months (22). Few case reports have reported interesting outcomes after surgery for selected oligometastatic patients (3)(4)(5)(6)(7)(8)(9). Surgical resection can be performed safely in selected patients with isolated metastases to the para-aortic lymph node or isolated liver metastasis, achieving long-term survival as well as good palliation (23).…”

Section: Discussionmentioning

confidence: 99%

Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation

A¹,

Sempoux²,

Voutsadakis³

et al. 2019

Ann. Transl. Med.

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Synchronous tumors of the pancreas and gallbladder are rare and often attributed to an abnormal pancreato-biliary junction, which results in a persistent reflux of pancreatic secretions leading to chronic biliary inflammation. We present the case of a 73-year-old woman with synchronous lesions of the pancreas and gallbladder initially considered as two primary localized cancers and treated with curative intent. At relapse, targeted next generation sequencing (NGS), performed in search of potential therapeutic targets, uncovered the fact that the two lesions appeared to be clonally related. This case illustrates the problem of synchronous lesions of the pancreas and gallbladder. New pathologic assessments with comparative molecular analysis of mutational profiles may be helpful in this context.

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Synchronous adenocarcinoma of the gall bladder and pancreas in a young woman

Cited by 7 publications

References 5 publications

Multifocal pancreatobiliary malignancies: A diagnostic and therapeutic challenge

Multifocal pancreatobiliary malignancies: A diagnostic and therapeutic challenge

Synchronous primary duodenal papillary adenocarcinoma and gallbladder carcinoma: A case report and review of literature

Synchronous tumors of the pancreas and the gallbladder: a case report with targeted NGS evaluation

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