Synchronous and Metachronous Endocervical and Ovarian Neoplasms: A Different Interpretation of HPV Data

Detection of human papilloma virus subtypes 16 and P16ink4a in invasive squamous cell carcinoma of the fallopian tube and concomitant squamous cell carcinoma in situ of the cervix

“…The probes used for the test covered HPV types 16,18,31,33,35,39,45,51,52,56,58,59, and 68. Colposcopically directed cervical biopsy confirmed SCC in situ.…”

Synchronous tumours of the female genital tract

“…Nevertheless, the view that these are metastatic has been challenged and discussed in the literature, the alternative being that the neoplastic change in the ovary occurs as a part of a field change to a common oncogenic insult. It is postulated that this may be facilitated by transtubal transfer of HPV‐infected or transformed cells and disruption of the ovarian surface due to ovulatory injury in women in their reproductive years 71 . The relatively good outcome and indolent course of cases with minimally invasive endocervical primaries with isolated ovarian involvement documented 67 lends some credence to this view.…”

“…It is postulated that this may be facilitated by transtubal transfer of HPVinfected or transformed cells and disruption of the ovarian surface due to ovulatory injury in women in their reproductive years. 71 The relatively good outcome and indolent course of cases with minimally invasive endocervical primaries with isolated ovarian involvement documented 67 lends some credence to this view. It is possible that more detailed clonal analysis will be able to elucidate the exact relationship between such tumours in the future.…”

Ovarian recurrence from a Stage 1b1 cervical adenocarcinoma previously treated with radical vaginal trachelectomy: A case report

“…In the Ronnett series, 17 of 19 patients who underwent lymphadenectomy had no lymph nodal metastasis, and of the 18 cases with available follow-up, 14 patients were alive with no evidence of disease (10-83 months' follow-up period) and two others were alive with disease. Due to these unusual pathological features and apparently favourable clinical outcome, the possibility that this represents an example of an independent ovarian neoplasm as a result of a 'field effect' of oncogenic HPV has also been suggested (Reichert, 2005a) though refuted (Reichert, 2005b). This case identifies the importance of follow up for women previously treated for an early cervical cancer.…”