Synchronous bilateral medullary carcinoma of breast: Is it metastasis or second primary?

Chandrika,; Permi, Harish S.; Prasad, Hari; Mohan, Rajashekar; Shetty, K Jayaprakash; Patil, Channappa

doi:10.4103/0973-1482.95193

Cited by 13 publications

(13 citation statements)

References 6 publications

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“…However, in our cohort, only 6.0% of the TMBC patients had a family history of breast cancer, indicating that the correlation between TMBC and the BRCA1 mutation remains to be determined. In 2012, Chandrika et al [28] reported a case of triple-negative synchronous bilateral medullary carcinoma, and a similar result was found in one of our patients who presented with two synchronous ipsilateral breast lesions which showed triple-negative disease.…”

Section: Discussionsupporting

confidence: 86%

Clinicopathologic Characteristics of Typical Medullary Breast Carcinoma: A Retrospective Study of 117 Cases

et al. 2014

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PurposeThis study analyzed the clinicopathologic characteristics of typical medullary breast carcinoma (TMBC) in a cohort of Chinese patients.MethodsWe conducted a retrospective review of clinical data including general information, pathologic results, treatment regimens, and patient survival in cases of TMBC diagnosed between February 2004 and April 2011.ResultsA total of 117 patients were enrolled, with a median age of 52 years (range, 28∼92 years). Stage I and II disease accounted for 31.6% and 61.6% of the cases, respectively. Hormonal receptor negative disease (estrogen receptor negative, 68.4%; progestogen receptor negative, 86.3%) was more prevalent in this population. Human epidermal growth factor receptor-2 (HER-2) positivity was 20.5%, while equivocal and HER-2 negative cases represented 16.2% and 63.2% of the cohort. The triple-negative, luminal, and HER-2 overexpressing subtypes constituted 44.4%, 31.6%, and 15.4% of the cases, respectively. The various TMBC subtypes showed no differences regarding tumor size, rates of lymph node(s) metastasis, TNM staging, treatment regimens, and 2-year recurrence rates. However, patients with triple-negative disease were more likely to be younger, when compared to those with luminal disease (P = 0.002). At a median follow-up of 56 months (range, 2–112 months), the 2-year disease-free survival and overall survival rates were 99.1% and 98.2%, respectively.ConclusionEarly stage disease dominated the study cohort, and at two years after surgery, recurrence was extremely low. The heterogeneity of molecular subtypes was clearly shown, and no apparent differences were found among the clinicopathologic characteristics of the triple-negative, luminal, and HER-2 overexpressing subtypes.

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Section: Discussionsupporting

confidence: 86%

Clinicopathologic Characteristics of Typical Medullary Breast Carcinoma: A Retrospective Study of 117 Cases

et al. 2014

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“…The second tumour in the contralateral breast can be either synchronous (within 6 months of the primary tumour) or metachronous (after 6 months of the primary). 2 In the present case, the second lump in the left axilla developed 4 months after the right breast lump. The exact etiology is not clearly defined (Chen et al) but among the various hypothesis suggesting risk factors for bilaterality of breast carcinomas; lobular carcinoma as the primary carcinoma is considered as an important factor.…”

Section: Discussionmentioning

confidence: 85%

“…Bilateral Breast Carcinoma (BBC) is an uncommon presentation with an incidence of 2-5% of all breast malignancies, Chandrika et al 1,2 Understanding the various factors contributing the development of contralateral tumour is important to ameliorate its altered clinical course, exaggerated treatment course and cost, aggravated prognosis as compared to unilateral tumour. Here is a case of a 56-year-old female with bilateral breast carcinoma with same histology and different grade on either side, who was managed adequately and recovered well.…”

Section: Introductionmentioning

confidence: 99%

A rare case report of bilateral synchronous carcinoma breast

et al. 2017

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Bilateral Breast Carcinoma (BBC) is a rare entity with incidence of synchronous carcinoma being 2-5% of all breast malignancies, which is much less than metachronous carcinoma. Synchronicity/metachronicity are usually associated with local and lymphatic spread and with blood-borne spread to lungs, bones and liver. Moreover, BBC are mostly lobular carcinomas but we report a rare case of Infiltrating Ductal Carcinoma (IDC), medullary type as the primary carcinoma. 56-year-old female who presented with a lump in her right breast for 6 months and lump in her left axilla. There was no e/o palpable lump in her left breast. Trucut biopsy was taken from both the lumps and was s/o infiltrating ductal carcinoma. Different histological subtypes with different grades of tumour in both breasts suggested synchronous primary tumours. Early detection of the contralateral tumour is of utmost importance emphasizing the significance of breast self-examination. Screening tools like MRI have a greater sensitivity compared to Mammography. There are no clear treatment guidelines for bilateral breast cancer. Patients are often treated with bilateral mastectomy, with breast conservative surgery having unclear importance. Meticulous diagnosis and appropriate management help to improve the longevity with an improved quality of life.

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“…Bilateral breast cancer has been reported from countries as diverse as USA, Italy, Greece, India, and Japan [1][2][3][4][5]. Therefore, the present paper documents the parameters discovered among the Igbo Ethnic Group, which is domiciled in South-Eastern Nigeria.…”

Section: Introductionmentioning

confidence: 90%

Bilateral breast cancer in a Nigerian community

Onuigbo¹

2017

Obstet Gynecol Rep

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In different parts of the world, there is published evidence regarding the bilateral synchronous occurrence of breast cancer. Therefore, this paper considers the parameters met among the Igbo Ethnic Group, who are domiciled mostly in South-Eastern Nigeria. The median age was 42 years. In the series of 6 cases, all but one was synchronous. The histological type tended to be the same on both sides, including one woman in whom three distinct types occurred bilaterally. Ductal carcinoma was the commonest type while the odd inflammatory carcinoma was prominent.

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Synchronous bilateral medullary carcinoma of breast: Is it metastasis or second primary?

Cited by 13 publications

References 6 publications

Clinicopathologic Characteristics of Typical Medullary Breast Carcinoma: A Retrospective Study of 117 Cases

Clinicopathologic Characteristics of Typical Medullary Breast Carcinoma: A Retrospective Study of 117 Cases

A rare case report of bilateral synchronous carcinoma breast

Bilateral breast cancer in a Nigerian community

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