Synchronous Colonic Adenocarcinoma and Extragenital Malignant Mixed Mesodermal Tumour

Jn, el-Jabbour; Cw, Helm; Km, McLaren; Smart, GE; Aitken, R. John

doi:10.1177/003693308903400609

Cited by 16 publications

(9 citation statements)

References 4 publications

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“…MMMT of peritoneal origin is much more rare. It was first reported by Ober and Black (1) in 1955, and the present case is only the 32nd to be reported worldwide (2−22) (Table 1). Almost all the patients were postmenopausal women, with the mean age being 68 years.…”

Section: Discussionsupporting

confidence: 56%

Malignant mixed mullerian tumor of primary mesenteric origin

Mikami¹,

Kuwabara²,

Tanaka³

et al. 2005

Int J Gynecol Cancer

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Malignant mixed müllerian tumor (MMMT) is a rare tumor. A literature search revealed very few reports on MMMT, especially those arising in the peritoneum. We recently encountered an MMMT of primary mesenteric origin associated with left fallopian tube cancer. There have been no previous reports about its occurrence in the mesentery. When cases of peritoneal MMMT were reviewed, the disease was found to be associated with synchronous or metachronous gynecologic tumors of müllerian duct origin (ie, ovarian tumors, primary serous carcinoma of the peritoneum, fallopian tube cancer, endometrial cancer, and adenocarcinoma of the cervix) in 12 out of 32 patients (37.5%). Peritoneal MMMT are frequently associated with gynecologic tumors.

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Section: Discussionsupporting

confidence: 56%

Malignant mixed mullerian tumor of primary mesenteric origin

Mikami¹,

Kuwabara²,

Tanaka³

et al. 2005

Int J Gynecol Cancer

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“…Primary peritoneal neoplasms composed of both malignant epithelial and stromal elements have variously been referred to as extragenital malignant mixed mesodermal tumors (1)(2)(3)(4)(5), malignant mixed müllerian tumors (6 -18), carcinosarcomas (19 -21) and mixed tumors of müllerian type (22)(23)(24). This lack of consistent terminology reflects both the rarity of these lesions, mostly described in single case reports, as well as the uncertainties concerning the histogenesis.…”

mentioning

confidence: 99%

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Cokelaere¹,

Michielsen

Vos³

et al. 2001

Modern Pathology

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Extragenital malignant mixed mesodermal (mülle-rian) tumors (MMMT) are rare neoplasms, with but 24 well documented cases in the literature. Neuroendocrine differentiation in mixed müllerian neoplasms has been mentioned only anecdotally. We report on the clinical, pathological, and immunohistochemical features of a hitherto-undescribed extragenital MMMT with prominent neuroendocrine differentiation arising from the jejunal mesentery. This lesion was composed of a poorly differentiated epithelial component and a spindle cell component with heterologous (rhabdomyoblastic) differentiation. The bulk of the tumor consisted of small cell neuroendocrine carcinoma, which exhibited strong immunoreactivity for NSE, LEU-7, chromogranin A and synaptophysin. Electronmicroscopy confirmed the presence of neurosecretory dense-core granules. The primary mesenteric origin of the tumor was established at autopsy. Along with a brief review of previously reported extragenital MMMT some histogenetic concepts relevant to this case are discussed.

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“…MMMTs have also been associated with other primary tumors such as ovarian thecoma and serous adenocarcinoma [39, 40]. El-Jabbour et al reported a case of extragenital MMMT with a synchronous colonic adenocarcinoma [41]. …”

Section: Discussionmentioning

confidence: 99%

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

Kapur

Levin

2014

Case Reports in Oncological Medicine

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We report a case of a 53-year-old female who presented with chronic constipation and abdominal discomfort for six months. Her past surgical history was significant for a total abdominal hysterectomy with bilateral salpingooophorectomy, performed eight years ago, for uterine fibroids and endometriosis. Workup revealed a mass measuring 5 × 4.5 × 2 cm in the rectosigmoid colon. Patient underwent a low anterior resection and a fungating, centrally ulcerated rectosigmoid mass with a positive mesorectal margin was removed. Histopathology revealed a heterologous mixed mesodermal tumor (chondroid and osteoid elements). The epithelial component was compatible with a grade 2 endometrioid adenocarcinoma. Immunohistochemical stains were supportive, with positive expression for CK7 and ER, negative for CK20, and only very focally and weakly positive for both CDX2 and p63. Chromogranin, synaptophysin, and TTF-1 were negative. Following surgery, she was treated with five cycles of carboplatin (AUC 6) and paclitaxel (175 mg/m2), followed by irradiation. Twenty-six months later, patient continues to be asymptomatic and disease-free. Mixed müllerian mesodermal tumors mimicking colorectal cancer have been reported in the past. Our case highlights the rarity and the challenges encountered in diagnosing and treating these rare tumors.

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Synchronous Colonic Adenocarcinoma and Extragenital Malignant Mixed Mesodermal Tumour

Abstract: A synchronous occurrence of large bowel adenocarcinoma and extragenital malignant mixed mesodermal tumour (MMMT) is reported. This case represents the sixth extragenital MMMT reported in the literature.

Cited by 16 publications

References 4 publications

Malignant mixed mullerian tumor of primary mesenteric origin

Malignant mixed mullerian tumor of primary mesenteric origin

Primary Mesenteric Malignant Mixed Mesodermal (Müllerian) Tumor with Neuroendocrine Differentiation

Primary Malignant Mixed Müllerian Mesodermal Tumor Mimicking a Rectosigmoid Carcinoma: A Case Report and Review of the Literature

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