Synchronous colorectal adenocarcinoma and gastrointestinal stromal tumor (GIST)

Abstract

Synchronous CRC and GIST has been more frequently reported. Because of the limited number of cases, we cannot exclude an incidental relationship. The genetic pathways of tumorigenesis appear different for the two neoplasms. Further studies are needed to clarify a possible role of c-Kit in the development of colonic adenocarcinomas.

Small intestine-derived gastrointestinal stromal tumour diagnosed synchronously with colon adenocarcinoma: a and review of the literature

“…A review of case reports in the literature showed that stromal tumours of the small intestine are mostly small and are associated with low to intermediate risk when classified according to Fletcher's risk classification [17]. (Tables 1 and 2) [4,10,12,13,[18][19][20][21][22][23]. The presented case also had a small ileum-originated low-risk GIST.…”

“…Why GISTs are seen with other malignant tumours is not well understood. The hypothesis, based on a few experimental studies, is that a single carcinogen or carcinogenic pathway plays a role in the neoplastic proliferation of cell series from different histological subtypes [4]. Taking this into account, it can be suggested that cell stimulation is achieved via the same carcinogenic factor during the proliferation of both epithelial and stromal cells.…”

“…Melis et al concluded that contemporary research data showing that mutation is a predisposing factor in neoplastic progression, and is the common mechanism in the pathogenesis of GIST and colorectal adenocarcinomas, are inconclusive [4]. The genetic pathways in the tumourigenesis of two different neoplasms (GIST and colorectal adenocarcinoma) being different was suggested as a probable cause; however; although the number of cases is limited, some researchers have reported that they could not rule out the possibility that this association is not coincidental.…”

“…Most commonly the diagnosis is made coincidentally during surgery performed for other reasons. Some researchers have reported that the genetic features of tumour progression are the most probable cause of this co-occurrence [4]. Although it is seen more often with GIS malignancies, a review of the literature showed that this co-occurrence is more common with stromal tumours of the stomach and less common with GISTs of small intestine origin.…”

Coexistence of prostate cancer and colorectal cancer in a patient with gastrointestinal stromal tumor

“…In addition, gene mutations predisposing to the development of various types of neoplasms may play a role. Melis et al (6) failed to find evidence of common mechanisms in the pathogenesis of GISTs and colorectal adenocarcinoma. In their case report, Kaffes et al (7) indicated that Helicobacter pylori (H. pylori) infection was a favoring factor.…”