Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Vennepureddy, Adarsh; Nehru, Vijeyaluxmy Motilal; Liu, Y.; Mohammad, Farhan; Atallah, Jean-Paul

doi:10.1155/2016/7953745

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…Vennepureddy et al [10], reports the case of a A 77-year-old female with history of hypertension, diabetes mellitus type II, dyslipidemia, and chronic kidney disease who presented to the hospital after a fall, Her clinical examination and lab tests on admission showed an irregularily shaped mass on the outer quadrant of the left breats, an acute kidney injury, normocytic normochromic anemia, and multiple bony lesions on the MRI. The patient had a synchronous diagnosis of multiple myeloma, breast cancer, and monoclonal B-Cell Lymphocytosis.…”

Section: Discussionmentioning

confidence: 99%

Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis<br /> <div> <br /> </div>

Harrar,

Raissi,

Bouchehboun

et al. 2023

IJBSE

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Breast carcinoma is a tumor that tends to metastasize to various organs. The hasty diagnosis of metastasis in patients treated for breast carcinoma who report symptoms for another malignant tumor, may be the cause of diagnostic and therapeutic delay. We report the case of a patient with breast ductal carcinoma, having completed her therapeutic protocol, she came in 3 years later with severe bone pain, epistaxis and headache in a context of asthenia and anorexia, suggesting a relapse of her breast cancer with bone metastasis. On clinical examination, the patient presented with cutaneous and mucosal pallor. She had no other signs of secondary localization, the performance of electrophoresis and immunofixation of serum proteins, led to a diagnosis of multiple myeloma. This observation highlights the diagnostic difficulty that can arise in patients treated for breast carcinoma who present with a malignant hemopathy mimicking a metastasis of the initial cancer, or other cases where the multiple myeloma is synchronous with other malignancies. This clinical similarity may delay treatment and worsen the patient's condition. This situation can be avoided by the simple performance of protein electrophoresis, which is a relevant method of diagnosis and follow-up of monoclonal gammopathies thanks to the efficient separation of serum proteins and quantification of monoclonal peaks.

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Section: Discussionmentioning

confidence: 99%

Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis<br /> <div> <br /> </div>

Harrar,

Raissi,

Bouchehboun

et al. 2023

IJBSE

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“…Synchronous malignancies in the same anatomical site are very unusual [ 9 - 10 ]. This case is one of those scarce reports of the simultaneous occurrence of BALT lymphoma and SCLC in the same anatomical site.…”

Section: Discussionmentioning

confidence: 99%

Synchronous Pulmonary Neoplasms: A Chance Occurrence or is There More Than Meets the Eye?

Ibrahim

Saqib

Pant

et al. 2018

Cureus

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Primary bronchus-associated lymphoid tissue (BALT) lymphoma comprises 5% of non-Hodgkin’s lymphoma (NHL) and usually has an indolent course. Synchronous primary lung cancers with BALT lymphoma are seldom seen in patients with adenocarcinoma of the lung. Synchronous squamous cell carcinoma (SCC) and BALT lymphoma is an extremely rare occurrence. We report an unusual case of stage 4 BALT lymphoma requiring treatment that revealed an underlying ipsilateral mass causing a diagnostic dilemma. An 84-year-old female with a history of systemic lupus erythematosus, deep vein thrombosis, and thrombotic microangiopathy presented to the hospital with cough and dyspnea on exertion. A chest X-ray revealed right hemi-thorax opacification and computed tomography (CT) of the chest showed a large right effusion and a soft tissue density extending into the proximal right bronchus. She required repeated thoracentesis until the pleural fluid analysis showed the presence of small lymphocytes and bronchial washings revealed an abnormal B cell population consistent with extranodal marginal zone lymphoma. The patient received four cycles of bendamustine and rituximab resulting in near-complete resolution of the effusion. Four months from diagnosis, imaging showed an increase in the size of the soft tissue density with pathologic fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET). A CT-guided biopsy was consistent with squamous cell lung cancer (SCLC) and radiotherapy was started for clinical stage 2 disease since the patient was not a surgical candidate. BALT lymphoma is a low-grade malignancy classified as extranodal marginal zone lymphoma with a five-year survival rate of over 80%. Several cases of synchronous lung adenocarcinoma and BALT lymphoma have been described. However, our case is among the rare few cases of synchronous occurrence of SCLC with BALT lymphoma. This report highlights the challenges associated with establishing an accurate and timely diagnosis.

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“…Only sporadic cases have been reported concerning multiple myeloma (MM) with sMPMTs. 2,3 In addition, multiple cycles of combination chemotherapy are necessary for the treatment of newly diagnosed MM. [4][5][6][7][8] Therefore, deciding when and how to start treatment for sMPTS may be difficult.…”

Section: Introductionmentioning

confidence: 99%

<p>The Synchronous Presence of Multiple Myelomas and Other Primary Malignant Tumors: Case Series with Literature Review</p>

Liu

Song

et al. 2020

CMAR

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The synchronous presence of multiple myeloma (MM) and other primary malignant tumors (PMTs) were rarely reported. This study aimed to analyze several cases of MM and other PMTs in order to improve clinicians' understanding of multiple myeloma (MM) with sMPMTs. Methods: This study was a retrospective trial. We retrospectively analyzed six cases of the synchronous presence of MM and other PMTs and reviewed the literature to summarize the clinical features and treatment. Results: The results showed that five cases of immunoglobulin G (IgG) and one case of kappa light chain; D-S stage: six case of stage III; ISS stage: one case of stage I, two cases of stage II, and three cases of stage III; one case each of gastric cancer (pT2N0MO, stage I), breast cancer (pT1bN0M0, stage I), lung cancer (pT1N0M0, stage I), cervical cancer (stage IB2), thyroid cancer (pT1N0M0, stage I), and diffuse large B-cell lymphoma (Ann-Arbor stage II); three of five patients underwent surgery alone, one patient underwent surgery first and then received chemotherapy at the time of pleural metastasis and the other patient only received radiotherapy; two patients were still alive, three died of progression of MM, and one died of lung cancer. The median survival time was 33.5 months (95% CI, 14.17 to 59.5months). Conclusion: The relationship between synchronous MM and other PMTs remains unknown. Clinicians should improve their understanding of MM with sMPMTs by carrying out multidisciplinary collaboration and a patient-oriented approach to optimize treatment and prolong the survival rates of patients.

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Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Cited by 8 publications

References 17 publications

Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis<br /> <div> <br /> </div>

Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis<br /> <div> <br /> </div>

Synchronous Pulmonary Neoplasms: A Chance Occurrence or is There More Than Meets the Eye?

<p>The Synchronous Presence of Multiple Myelomas and Other Primary Malignant Tumors: Case Series with Literature Review</p>

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Synchronous Diagnosis of Multiple Myeloma, Breast Cancer, and Monoclonal B-Cell Lymphocytosis on Initial Presentation

Cited by 8 publications

References 17 publications

Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis&lt;br /&gt; &lt;div&gt; &lt;br /&gt; &lt;/div&gt;

Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis&lt;br /&gt; &lt;div&gt; &lt;br /&gt; &lt;/div&gt;

Synchronous Pulmonary Neoplasms: A Chance Occurrence or is There More Than Meets the Eye?

<p>The Synchronous Presence of Multiple Myelomas and Other Primary Malignant Tumors: Case Series with Literature Review</p>

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Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis<br /> <div> <br /> </div>

Multiple Myeloma Mimicking Bone Metastasis: The Contribution of Biochemistry Laboratory to Differential Diagnosis<br /> <div> <br /> </div>