Synchronous early gastric cancer and gastrointestinal stromal tumor in the stomach of a patient with idiopathic thrombocytopenic purpura

Abstract

The synchronous occurrence of gastrointestinal stromal tumour (GIST) in the stomach and early gastric cancer is uncommon, with only a few previous reports. In particular, the collision of GIST and early gastric cancer in a patient with idiopathic thrombocytopenic purpura (ITP) has never been reported. We present the case of a 78-year-old male patient with ITP who was diagnosed with a synchronous development of GIST and early gastric cancer of the stomach. He underwent an elective subtotal gastrectomy with splenectomy. We discuss whether the development of GIST in the stomach in concert with early gastric cancer is an incidental coexistence or involve the same carcinogenic agents. Furthermore, it is not known whether or not such a situation is connected with ITP. To our knowledge this is the second report of a small GIST concomitant with an early gastric cancer and the first one in a patient with ITP.

The impact of additional malignancies in patients diagnosed with gastrointestinal stromal tumors

“…There have been many reports of additional malignancies in patients diagnosed with a GIST. However, it is unclear whether this represents a coincidental finding, improved detection or surveillance bias or whether a potential causal association exists . Similarly, it is difficult to ascertain whether the apparent reported higher risk of additional malignancies is related to cancers present at the index diagnosis of a GIST or those developing at a later time point.…”

“…However, it is unclear whether this represents a coincidental finding, improved detection or surveillance bias or whether a potential causal association exists. 8,9,[13][14][15][16][17][18][19][20][21][22] Similarly, it is difficult to ascertain whether the apparent reported higher risk of additional malignancies is related to cancers present at the index diagnosis of a GIST or those developing at a later time point. If a true association between GISTs and additional malignancies does exist, both modes of occurrence have clinical relevance.…”

Endoscopic Submucosal Dissection for Early Gastric Cancer in a Patient with Myelodysplastic Syndrome

“…3 Despite the high rate of bleeding, this procedure has been performed successfully in patients with bleeding diatheses, such as liver cirrhosis or chronic renal failure. 4,5 However, there have been no reports on successful ESD for EGC in patients with thrombocytopenia due to hematologic diseases.…”

Midenin Senkron Gastrointestinal Stromal Tümör ve Primer Adenokarsinomu

“…Metastases may develop in the abdominal cavity, liver, bones, soft tissues, skin, lymph nodes and the lungs after 10-15 years of primary surgery. Patients with advanced GIST, which progress rapidly and result in organ destruction, have a poor prognosis (8,9).…”