Synchronous Endometrial and Cervical Tumors in a 26-Year-Old Nullipara: Diagnostic Modalities Updated

Abstract

Proton magnetic resonance spectroscopy (MRS), performed on conventional magnetic resonance imaging (MRI) scanners, provides useful information at the biochemical level. MRS has been used to measure tissue concentrations of proton-containing compounds such as organic and amino acids, and sugars in living tissues. We have used MRS in a 26-year-old female with suspected cervical and endometrial carcinomas. With the use of the above mentioned technique, biochemical differences in the endometrium and the cervix tissues were detected. The presented case is the first virgin patient in the relevant literature in whom endometrial and cervical carcinoma was detected. Choline (Cho), creatine (Cr), N-acetylaspartate (NAA), lipid and lactate region of the MRS spectrum suggested that the technique could be used as an indicator of metabolic alterations in the cervical and endometrial tumor cells.

Synchronous primary malignant neoplasms of the cervix and endometrium

“…When similar tissues of the female genital tract are subjected to carcinogen exposure during fetal/embryological development, synchronous tumors may develop (5). In gynecological oncology, endometrial cancers with simultaneous ovarian cancers are the most common, whereas, to the best of our knowledge, only 9 cases of carcinoma of the cervix with carcinoma of the endometrium have been reported to date (3,6–10); the tumors comprised different histopathological subtypes, whereas in only two cases (~22%) the types were the same as in the present case.…”

“…The concomitant malignancies are frequently diagnosed as metastatic disease. In the majority of the cases, the patients with >1 gynecological neoplasms present with synchronous endometrial and ovarian cancer (1), whereas synchronous primary malignancies of the uterus are even rarer (2,3). We herein present an unusual case of cervical squamous cell carcinoma and endometrial adenocarcinoma occurring simultaneously.…”

Synchronous Primary Carcinoma of Uterine Cervix and Endometrium - Single-center retrospective study

“…Synchronous MPM from different parts of one organ as the uterus are even more infrequent. Stage of both malignancies at diagnosis is considered of prognostic significance in MPM [7]. We analyzed a series of 1460 patients, who underwent surgery in our clinic for either endometrial or cervical cancer, or both.…”

Synchronous primary carcinoma of the cervix and endometrium with early lymph node recurrence

“…Concurrent neoplasms of the cervix and endometrium are rarer. To our knowledge, only 12 cases of synchronous cervical and endometrial carcinoma have been published in the English literature [2–6].…”