Synchronous Incidental Double Parathyroid Adenomas and Papillary Thyroid Carcinoma

Alghamdi, M A; Alsaif, Abdulaziz; Altwijri, A S; Alsaif, Faisal; Alsunitan, Roqayah I; Almoagal, R O

doi:10.4103/njcp.njcp_635_19

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2022

2024

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Cited by 2 publications

References 26 publications

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Histopathological Assessment for Papillary Thyroid Carcinoma

Lam

2022

Methods in Molecular Biology

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Histopathological Assessment for Papillary Thyroid Carcinoma

Lam

2022

Methods in Molecular Biology

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Incidental synchronous intrathyroidal parathyroid carcinomas and papillary thyroid microcarcinoma with compressive neck mass and primary hyperparathyroidism: case report and literature review

Xu,

Zheng,

Wei

2024

BMC Endocr Disord

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Background Parathyroid carcinoma (PC) is a rare malignancy, often diagnosed incidentally through postoperative pathological examination. The occurrence of nodular goiter, intrathyroidal parathyroid carcinoma, contralateral parathyroid adenoma (PA), and papillary thyroid microcarcinoma (PTMC) is extremely uncommon, which prompted us to report our case experience. Case presentation We describe a 67-year-old male who presented with a cervical mass causing tracheal compression, which prompted him to seek medical advice. Based on preoperative auxiliary examination results from color Doppler ultrasound, SPECT parathyroid imaging, and blood tests, he was initially diagnosed with a suspected parathyroid adenoma and nodular goiter. Excision of the right lobe and isthmus of the thyroid, and left superior parathyroid gland was conducted, which were sent to intraoperative frozen pathological examination. During intraoperative observation, adhesion around the right thyroid lobe was discovered. Consequently, right central area lymph node dissection was performed due to suspicion of an aggressive malignant tumor. Histology and immunohistochemistry analysis revealed incidental intrathyroidal parathyroid carcinoma, contralateral parathyroid adenoma, classical papillary thyroid microcarcinoma, and nodular goiter. Conclusion Parathyroid carcinoma should be highly suspected when extremely high levels of PTH and severe hypercalcemia are present, which cannot be simply explained by a preoperatively localized parathyroid adenoma, especially when suspicious malignant adhesion is found during intraoperative exploration. In cases where multifocal thyroid nodules are associated with increased uptake of 99Tc-sestamibi, the possibility of coexisting carcinomas should be considered, not only for thyroid malignancy but also for the potential presence of intrathyroidal parathyroid carcinoma.

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Synchronous Incidental Double Parathyroid Adenomas and Papillary Thyroid Carcinoma

Cited by 2 publications

References 26 publications

Histopathological Assessment for Papillary Thyroid Carcinoma

Histopathological Assessment for Papillary Thyroid Carcinoma

Incidental synchronous intrathyroidal parathyroid carcinomas and papillary thyroid microcarcinoma with compressive neck mass and primary hyperparathyroidism: case report and literature review

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