Synchronous intraductal papillary mucinous neoplasm and a pancreatic neuroendocrine tumor: more than a coincidence?

Costa, Juliana M; Carvalho, Sofia Daniela; Soares, João

doi:10.17235/reed.2017.5003/2017

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…Their symptomatology is mostly related to the effect of the massive tumor itself on the pancreas or on the surrounding structures, as well as to the correlation with the meta changes [7]. When the symptomatology is present, it is shown as abdominal pain, weight loss, jaundice, more rarely there can also be present anorexia, nausea, fatigue, palpable masses in the abdomen, and the other [8]. Mainly, NF-pNETs are presented as asymptomatic and are accidentally discovered, the most commonly as incidental findings within the diagnostics of other diseases [7,8].…”

Section: Case Reportmentioning

confidence: 99%

Laparoscopic enucleation of a neuroendocrine tumor on the posterior aspect of the pancreas: Case report and literature review

Eric¹,

Milosavljević²,

Tadić

et al. 2021

Srp Arh Celok Lek

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Introduction Introduction. Neuroendocrine tumors of the pancreas are rare neoplasms. They are divided into two groups: functional and non-functional. Non-functional tumors represent a diagnostic challenge, given that they often remain asymptomatic and are diagnosed as an incidental finding. Case outline. We present a patient in whom the tumor was discovered at the junction of the body and the tail of the pancreas on the dorsal side. The patient had no specific symptomatology, with no loss in body weight. Considering the conducted diagnostics and the condition of the patient, we decided to perform a laparoscopic enucleation. This procedure has been applied in a safe and efficient manner, so the operative and postoperative course passed without complications. The definitive histopathological examination confirmed the finding that it was a non-functional pancreatic neuroendocrine tumor. Conclusion. Laparoscopic enucleation is an effective and safe treatment modality of these tumors with well-known advantages compared to open surgery, but there is always a tending to improve already existing results and thus to contribute not only to treatment but to greater and better comfort of the patient

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Section: Case Reportmentioning

confidence: 99%

Laparoscopic enucleation of a neuroendocrine tumor on the posterior aspect of the pancreas: Case report and literature review

Eric¹,

Milosavljević²,

Tadić

et al. 2021

Srp Arh Celok Lek

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Case report: composite pancreatic intraductal papillary mucinous neoplasm and neuroendocrine tumor: a new mixed neuroendocrine-non-neuroendocrine neoplasm?

Chen

Wang

et al. 2021

Diagn Pathol

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Background Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNEN) of the pancreas are extremely rare. Their pathogenesis and molecular landscape are largely unknown. Here, we report a case of mixed pancreatic intraductal papillary mucinous neoplasm (IPMN) and well-differentiated neuroendocrine tumor (NET) and identify its genetic alterations by next-generation sequencing (NGS). Case presentation A fifty-year-old male was admitted into the hospital for evaluation of a pancreatic lesion detected during a routine examination. Abdominal ultrasound indicated a hypoechoic mass of 2.6 cm at the head of the pancreas. Malignancy was suspected and partial pancreatectomy was performed. Thorough histopathological examination revealed a mixed IPMN-NET. In some areas, the two components were relatively separated, whereas in other areas IPMN and NET grew in a composite pattern: The papillae were lined with epithelial cells of IPMN, and there were clusters of NET nests in the stroma of papillary axis. NGS revealed shared somatic mutations (KRAS, PCK1, MLL3) in both components. The patient has been uneventful 21 months after the surgery. Conclusions Our case provides evidence of a common origin for mixed IPMN-NET with composite growth features. Our result and literature review indicate that KRAS mutation might be a driver event underlying the occurrence of MiNEN. We also recommend the inclusion of mixed non-invasive exocrine neoplasms and neuroendocrine neoplasms into MiNEN.

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Endoscopic Removal of Sharp-Pointed Foreign Bodies with Both Sides Embedded into the Duodenal Wall in Adults: A Retrospective Cohort Study

Yu¹,

Li²,

Zhou³

et al. 2021

IJGM

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Purpose Sharp-pointed FBs with both sides embedded in the duodenal wall are rare. Compared with smooth edged FBs, sharp objects are more likely to be associated with significant adverse events, when penetrating the wall of the digestive tract. The clinical features of patients who experienced sharp-pointed FBs embedded in both sides of the duodenum were retrospectively analyzed, as were the efficacy and safety of endoscopic removal of these FBs. Patients and Methods This retrospective study included 21 adults with both sides of sharp-pointed FBs embedded into the duodenal wall who were admitted to the Second Xiangya Hospital in China between January 1, 1996, and May 31, 2021. Data associated with the endoscopic removal of these FBs were collected from the electronic medical record system (EMRS) of the hospital. Results The incidence rate of duodenal total FBs and FBs embedded in both sides was 8.87% and 1.03%, respectively. The success rate of endoscopic treatment was 100.00% in 124 patients without embedded duodenal FBs and 97.14% in 35 patients with one side embedded duodenal FBs. Of the 21 patients with FBs embedded in both sides of the duodenal wall, endoscopic removal was successful in 85.71% of patients, whereas 14.29% required surgery. FBs removed from these patients included toothpicks in 12; needles in 3; jujube pits in 2; and a chopstick, dentures, fish bones, and chicken bones in one each. Most of these 21 FBs were located in the bulb and descending duodenum, followed by the third part of duodenum. Conclusion Sharp-edged FBs with both sides embedded in the duodenal wall are rare. Endoscopic removal may be considered as a feasible, safe, and effective method of removing sharp-pointed FBs with both sides embedded in the duodenal wall. And if endoscopic removal is unsuccessful, surgical management can be a secondary option.

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Synchronous intraductal papillary mucinous neoplasm and a pancreatic neuroendocrine tumor: more than a coincidence?

Cited by 5 publications

References 9 publications

Laparoscopic enucleation of a neuroendocrine tumor on the posterior aspect of the pancreas: Case report and literature review

Laparoscopic enucleation of a neuroendocrine tumor on the posterior aspect of the pancreas: Case report and literature review

Case report: composite pancreatic intraductal papillary mucinous neoplasm and neuroendocrine tumor: a new mixed neuroendocrine-non-neuroendocrine neoplasm?

Endoscopic Removal of Sharp-Pointed Foreign Bodies with Both Sides Embedded into the Duodenal Wall in Adults: A Retrospective Cohort Study

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