Synchronous Ipsilateral Parotid Tumors With Cytologic-Histologic Correlation

Gvozdjan, Kristina; Groth, John V.; Patel, Tushar M.; Guzman, Grace; David, Odile; Cabay, Robert J.

doi:10.1093/ajcp/142.suppl1.062

Cited by 2 publications

(4 citation statements)

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“…Different primary tumours or multiple tumours of salivary glands are rare and when they occur, the most common association with WT is other benign salivary gland tumours, primarily pleomorphic adenoma . Multiple tumours may be considered from three perspectives: according to their histological type with identical or different histology, time of development as synchronous or metachronous and localisation as unilateral, bilateral and multiple .…”

Section: Association With Other Salivary Gland Tumours and Other Extrmentioning

confidence: 99%

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Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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Warthin's tumour (WT) is a benign epithelial salivary tumour, one type of salivary adenoma. Histologically, WT is structured of two components, epithelial tissue that often lines cystic formations and lymphoid tissue in the tumour stroma. FNA is a reliable diagnostic approach in the diagnosis of salivary gland lesions allowing a highly accurate categorization of benign tumour‐like lesions, benign tumours and malignant tumours. In the proposed Milan reporting system of salivary gland lesions, WT is categorized in the IVA group of benign neoplasms. Accurate cytological diagnosis is straightforward when three characteristic components are present: oncocytes, either isolated or associated in clusters, lymphocytes and lymphoid cells and often an inflammatory/necrotic‐like substance. Also, specific features of scintigraphy and radiological imaging contribute to the diagnosis of WT. WT is categorized according to Seifert G. et al in 4 types, depending on the proportions of the epithelial component and lymphoid stroma. Differential cytopathological and pathohistological diagnosis include other salivary gland lesions with lymphoid, oncocytic epithelial and cystic components. In some cases, such as the metaplastic WT variant, there are additional cytopathological and histological diagnostic difficulties. Moreover, bilateral, multicentric or multiple and infrequently seen extra‐salivary localizations of WT are associated with further cytopathological diagnostic difficulties. Also, a rare possibility of malignant transformation of the epithelial or lymphoid component of WT as well as possible association with other primary tumours remains a challenge in accurate cytopathological and histological diagnosis of WT.

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Section: Association With Other Salivary Gland Tumours and Other Extrmentioning

confidence: 99%

“…Thus, serial sections of the involved salivary gland reveal additional sub‐clinical lesions in 50% of cases. In addition to multicentric WT in one salivary gland, WT can also be found in multiple locations in different salivary glands and tissues …”

Section: Introductionmentioning

confidence: 99%

Cytopathology and diagnostics of Warthin's tumour

Sučić

Ljubić²,

Perković³

et al. 2020

Cytopathology

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“…2 Benign tumors reported to coexist with WT include pleomorphic adenoma, basal cell adenoma, sebaceous lymphadenoma, myoepithelioma, and oncocytoma. 2,4,6 Till date, the synchronous occurrence of an OPC and WT has not been reported. Cystic lesions of the salivary glands include a wide range of differential diagnoses, both non-neoplastic and neoplastic.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 The neoplasm most frequently accompanying a WT, apart from a WT, is a pleomorphic adenoma; however, benign cysts like lymphoepithelial cysts, benign tumors like basal cell adenoma, as well as salivary gland carcinomas such as mucoepidermoid carcinoma (MEC) and salivary duct carcinoma arising in the same gland as a WT have been documented. [2][3][4][5][6] Cystadenomas are benign salivary gland neoplasms that are considerably rare, accounting for 4% of all salivary gland neoplasms. 7 They occur in major as well as minor salivary glands, above 40 years of age, and are more common in women.…”

Section: Introductionmentioning

confidence: 99%

Synchronous Oncocytic Papillary Cystadenoma and Warthin Tumor of the Parotid Gland

et al. 2019

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Warthin tumor (WT) is the second most common benign salivary gland neoplasm. It is also the most frequent salivary gland tumor to occur synchronously or metachronously with another salivary gland neoplasm, in the same gland or on the other side. Oncocytic papillary cystadenomas (OPCs) are rare neoplasms that are more common in minor salivary gland locations and in women. We describe in detail the case of a 73-year-old male smoker with synchronous OPC and WT of the parotid gland. On microscopy, both tumors resembled each other considerably, with the only difference being that the OPC lacked the tumor-associated lymphoid proliferation characteristic of WT. These findings highlight that OPC bears considerable similarity to WT. While this morphological similarity may lead to misdiagnosis on rare occasions, it does not affect patient management, as clinical behavior of both these tumors is similar.

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Synchronous Ipsilateral Parotid Tumors With Cytologic-Histologic Correlation

Cited by 2 publications

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Cytopathology and diagnostics of Warthin's tumour

Cytopathology and diagnostics of Warthin's tumour

Synchronous Oncocytic Papillary Cystadenoma and Warthin Tumor of the Parotid Gland

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