Synchronous lung cancer presenting with small cell carcinoma and squamous cell lung carcinoma: a case report

Abstract

Synchronous multiple primary lung cancers are separate tumors presenting at the same time with different histology. We present a rare case of a 64-year-old patient with a combination of small-cell lung carcinoma (SCLC) and squamous carcinoma in two different sites with metastasis of SCLC in the mediastinal lymph node. The SCLC diagnosis was performed via bronchoscopy, and the other diagnosis via CT-guided transthoracic biopsy. It is often difficult to distinguish a synchronous tumor from intrapulmonary metastases. To date, there are no guidelines for the treatment of these cases. The management of synchronous multiple primary lung cancer (SMPLC), mainly surgical with chemotherapy or radiotherapy, must be studied according to the histological type, staging and molecular testing of the tumors. These rare cases of SMPLC require individual treatment and a multidisciplinary approach.

Synchronous multiple neuroendocrine primary lung cancer with endobronchial extension in a never smoker - An unusual manifestation

“…Distinguishing between a multi-center lung cancer and a primary tumor in a different organ becomes challenging when there is more than one primary lung tumor. 4 Roughly 60% of sMPLC consist of squamous cell carcinomas, with 60% of these instances demonstrating tumors of identical histologic type. 5 Trousse et al demonstrated that the presence of SCC in combination constituted 28.8% among 125 study patients with sMPLC.…”