Synchronous mixed germ cell tumor of testis and renal cell carcinoma: A rare presentation

Teratoma is frequently found in mixed germ cell testicular tumors in up to 80% of cases, but as a pure component it is reported in only 2–6% of cases. Metastatic disease may be seen in 29–76% of these cases in the adult population. We present the case of a 32 year old male patient diagnosed with a pure testicular teratoma in clinical stage I and a right renal cyst Bosniak IIF, as part of treatment he received chemotherapy, during which, radiological changes were observed at the level of renal cyst suggesting metastatic tumor.

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“… 4 The association between two synchronous primary testicular and renal tumors are even less frequent with scarce case reports. 5 …”

Section: Discussionmentioning

confidence: 99%

Embryonal carcinoma metastasis from pure testicular teratoma mimicking a complex renal cyst

Enrique

Joel

Eduardo

et al. 2021

Urology Case Reports

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“…A literature search revealed only 12 reports of metachronous testicular and renal malignancy; the majority diagnosed as mixed germ cell tumours. 5 There with no cases of metastatic pure seminoma and RCC cited. Cases most commonly reported the finding of an RCC on staging investigations of a testicular mass, contrasting to our case in which the metastatic lymph node was removed as part of staging and treatment of oligometastatic RCC.…”

Section: Discussionmentioning

confidence: 99%

The unexpected finding of a synchronous metastatic seminoma in para-aortic nodes excised in a case of clear cell renal cell carcinoma

Brewin

Tilley

Hayes

2021

Urology Case Reports

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Testicular cancer is the most common form of cancer in young men aged 15–35 years and renal cell carcinoma accounts for 3% of all adult malignancy but a synchronous presentation is rare, especially a metastatic classical pattern seminoma with no testicular involvement. We report a case of metastatic seminoma in para-aortic lymph nodes after open radical nephrectomy and retroperitoneal lymph node dissection for a large left clear cell RCC. This case highlights the atypical presentation of testicular cancer, the consideration of a non-RCC associated lymphadenopathy and the importance of lymph node dissection as a treatment option for RCC-associated nodal disease.

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“…Interestingly, both patients were diagnosed with clear cell renal carcinoma. To the best of our knowledge, no systemic scientifi c research data addresses the synchronous incidence of these types of malignant tumors arising from urogenital origin with only one published case study of this combination of tumors (21). This fact restricts the scope of debates on treatment strategies.…”

Section: Discussionmentioning

confidence: 99%

Extremely rare synchronous primary neoplasms in testicular cancer patients

Mrinakova¹,

Ondrušová²,

Lehotská³

et al. 2019

BLL

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OBJECTIVES: This study analyzes the incidence of multiple primary malignant neoplasms (MPN) in patients with testicular cancer (TC), the results are compared with literature fi ndings and assess the rarest subgroup of patients with MPN. PATIENTS AND METHODS: Clinical data of 1870 patients with TC treated or followed up in a single center in the period of 5/1970-12/2018 were collected and analyzed retrospectively in focus of the occurrence of MPN. RESULTS: The overall incidence of MPN was 150 (8.02 %). There were 89 cases of bilateral TC (59.3 %), of these 8 cases were synchronous (diagnosed within three months period from the primary diagnosis) and 81 metachronous (9 % and 91 % respectively). Non-testicular other primary malignancies (OPM) occurred in 61 cases (40.7 %), of which 59 cases were metachronous (96.7 %) and two cases were synchronous (3.3 %). Metachronous malignancies included mainly prostate cancer (n = 17 patients), kidney cancer (n = 13 patients) and colorectal cancer (n = 12 patients). Synchronous OPM was found in two patients. CONCLUSION: In our study we registered two cases of synchronous OPM, both histologically clear cell renal cancer. We have analyzed clinical characteristics, diagnosis and treatment strategies of synchronous OPM, in order to improve its diagnosis and therapy (Fig. 3, Ref. 22).

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Synchronous mixed germ cell tumor of testis and renal cell carcinoma: A rare presentation

Cited by 4 publications

References 12 publications

Embryonal carcinoma metastasis from pure testicular teratoma mimicking a complex renal cyst

Embryonal carcinoma metastasis from pure testicular teratoma mimicking a complex renal cyst

The unexpected finding of a synchronous metastatic seminoma in para-aortic nodes excised in a case of clear cell renal cell carcinoma

Extremely rare synchronous primary neoplasms in testicular cancer patients

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