Synchronous multiple lymphomatous polyposis and adenocarcinomata in the large bowel

Hopster, D; Smith, Pete; Nash, Jennifer; Elders, K.; Poston, Graeme J.

doi:10.1136/pgmj.71.837.443

Cited by 22 publications

(19 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, the current lymphoma extended systemically and occupied the regional lymph node, thus suggesting that lymphoma preceded the adenocarcinoma and was predominant. Hopster et al 18 postulated that lymphoma predisposes patients to adenocarcinoma due to the lack of immune surveillance; however, there is no evidence that immunodefi ciency induces activation of oncogenes or inactivation of tumor suppressor genes. The extreme rarity suggests that the synchronous development of colonic adenocarcinoma and lymphoma is probably due to chance rather to any specifi c association.…”

Section: Discussionmentioning

confidence: 98%

“…6 Eighteen case reports have been previously published since Cattell's report in 1947, as shown in Table 1. 5,6,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] Adenocarcinomas were located in the cecum in 3, in the ascending colon in 2, in the transverse colon in 1, in the descending colon in 1, in the sigmoid colon in 2, and in the rectum in 10 of 19 lesions. On the contrary, lymphomas were located in the cecum in 7, in the ascending colon in 3, in the transverse colon in 1, in the descending colon in 1, and in the rectum in 7 of 19 lesions.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Sasaki¹,

Hatanaka²,

Sahara³

et al. 2010

Surg Today

View full text Add to dashboard Cite

This report presents the case of a 62-year-old man with a collision tumor of primary malignant lymphoma and adenocarcinoma in the cecum. All regional mesenteric lymph nodes that were removed surgically were found to be occupied by lymphoma cells and no lymph nodes contained any cancer cells, although the primary carcinomas did exhibit lymphatic invasion. Malignant lymphoma was also seen in the duodenum. Systemic chemotherapy was administered for the malignant lymphoma, and a complete response was thus obtained. However, just after chemotherapy multiple liver metastases of adenocarcinoma emerged, and chemotherapy against adenocarcinoma was therefore continued. The occurrence of synchronous lymphoma and adenocarcinoma of the colorectum is rare. Furthermore, collisions of these different entities are also extremely unusual; so far only five such case reports have been published. The accurate clinical determination of the dominant tumor and a close follow-up is required for proper treatment in these cases.

show abstract

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Sasaki¹,

Hatanaka²,

Sahara³

et al. 2010

Surg Today

View full text Add to dashboard Cite

show abstract

“…It has been postulated that lymphoma might predispose the colon to adenocarcinoma because of altered immune function, allowing for cancerous cells to grow without surveillance. Cornes and others [12][13][14] observed that, in coexisting tumours, adenocarcinomas occur either synchronously with or after a diagnosis of lymphoma in the intestinal tract, suggesting an association between those two cancer types. Nonetheless, the rarity of such cases prevents any firm establishment of a relationship between lymphomas and adenocarcinomas 11,15 .…”

Section: Discussionmentioning

confidence: 99%

Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

et al. 2016

View full text Add to dashboard Cite

Synchronous cancers of different primary origin are rare. Here, we describe the case of a patient with concomitant diagnoses of rectal adenocarcinoma and splenic marginal zone lymphoma (smzl).A 57-year-old woman initially presented with abdominal pain. Physical examination and computed tomography demonstrated massive splenomegaly, and a complete blood count revealed microcytic anemia and lymphopenia. During the subsequent evaluation, she presented with hematochezia, melena, and constipation, which prompted gastroenterology referral. Subsequent endoscopic rectal ultrasonography revealed a T3N1 moderately differentiated rectal adenocarcinoma, with computed tomography imaging of chest, abdomen, and pelvis confirming no metastasis. Thus, the cancer was classified as clinical stage T3N1M0, stage iii. Bone marrow biopsy confirmed co-existing marginal zone lymphoma, and with the clinical presentation of massive splenomegaly, a diagnosis of smzl was made.The patient's management was individually tailored for simultaneous optimal treatment of both conditions. Concurrent treatment with neoadjuvant rituximab and 5-fluorouracil chemotherapy, with external-beam radiation therapy to the pelvis, was administered, followed by surgery consisting of en bloc splenectomy and distal pancreatectomy, and low anterior resection. The patient completed a standard course of adjuvant folfox (fluorouracil-leucovorin-oxaliplatin) chemotherapy and has remained disease-free for 7 years.To our knowledge, this report is the first to specifically describe simultaneous diagnoses of locally advanced rectal cancer and smzl. We also describe the successful combined neoadjuvant treatment combination of 5-fluorouracil, rituximab, and pelvic radiation.

show abstract

“…Jusqu'~ prdsent, un seul cas similaire a 6t6 rapport6 dans la littdrature [18]. Jusqu'~ prdsent, un seul cas similaire a 6t6 rapport6 dans la littdrature [18].…”

Section: Associationsunclassified

“…Up till now there is only one case report of a similar co-occurrence [18]. Up till now there is only one case report of a similar co-occurrence [18].…”

Section: Associationsmentioning

confidence: 99%

Polypose lymphomateuse multiple: une entité anatomo-clinique distincte. A propos d’un cas: revue de la littérature

1998

View full text Add to dashboard Cite

Synchronous multiple lymphomatous polyposis and adenocarcinomata in the large bowel

Cited by 22 publications

References 7 publications

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Collision tumor of primary malignant lymphoma and adenocarcinoma in the colon: Report of a case

Synchronous Rectal Adenocarcinoma and Splenic Marginal Zone Lymphoma

Polypose lymphomateuse multiple: une entité anatomo-clinique distincte. A propos d’un cas: revue de la littérature

Contact Info

Product

Resources

About