Synchronous non-collision melanoma and basal cell carcinoma arising from chronic lymphedema: a case report and review of literature

Sahned, Jaafar; Jestila, Tatum; Waheed, Abdül; Misra, Subhasis; Thakkar, Darshan

doi:10.1093/jscr/rjz105

Cited by 3 publications

(4 citation statements)

References 9 publications

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“…Recurrences at the primary site or other locations are considered one of the main challenges in GBCC management. A patient with BCC has a 45.2% risk of developing another BCC within 5 years [13]; therefore, lifelong or prolonged follow-up with regular skin screening is recommended [14].…”

Section: Discussionmentioning

confidence: 99%

Giant Ulcerative Basal Cell Carcinoma with Local Metastasis: A Case Report and Assessment of Surgical Techniques

Sahned¹,

Saeed

Misra³

et al. 2019

Cureus

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Giant basal cell carcinoma (GBCC) is a rare skin cancer characterized by an aggressive biological behavior with extensive local invasion, frequent metastasis, and associated poor prognosis. Wide local excision with sentinel lymph node biopsy is often warranted for this condition, and reconstruction by local rotational flap is one of the best surgical techniques for repairing similar skin cancers with a relatively large skin defect. A 59-year-old man who was a former construction worker with a significant smoking history presented with a single giant suspicious chronic ulcerating skin lesion measuring 9 x 7 cm that proved to be a basal cell carcinoma (BCC) on his left shoulder. The patient was negative for enlarged or palpable lymph nodes and underwent a wide local excision and primary repair with a local flap. Despite negative margins, his follow-up visits at six, nine, and 10 months revealed numerous suspicious lesions that further required multiple local wide excisions that showed new basal cell carcinoma and recurrence to the left axilla. Given the invasiveness of his skin cancer, he was referred to oncology and later treated by chemoradiation. Patients with multiple risk factors are associated with a higher incidence of more invasive skin cancer due to possible cumulative effects. The therapeutic approach for GBCC should involve multidisciplinary teams, with wide local resection of the tumor with possible sentinel lymph node biopsy, local rotational flap for reconstruction of the wide defect, and adjuvant chemoradiotherapy if necessary.

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Section: Discussionmentioning

confidence: 99%

Giant Ulcerative Basal Cell Carcinoma with Local Metastasis: A Case Report and Assessment of Surgical Techniques

Sahned¹,

Saeed

Misra³

et al. 2019

Cureus

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“…1,2 Numerous cutaneous malignancies have been described in lymphoedematous areas in literature, such as basal cell carcinoma, squamous cell carcinoma, melanoma, Kaposi sarcoma, Merkel cell carcinoma and several cutaneous lymphomas. [4][5][6] There are two main hypotheses about the promotion of skin cancer by lymphoedema. 4,5 The first one is the impaired lymphatic circulation causing chronic inflammation and altering Langerhans cells (LC) function and migration.…”

Section: A Case Of Multiple Basal Cell Carcinomas In An Immunocomprom...mentioning

confidence: 99%

“…[4][5][6] There are two main hypotheses about the promotion of skin cancer by lymphoedema. 4,5 The first one is the impaired lymphatic circulation causing chronic inflammation and altering Langerhans cells (LC) function and migration. These alterations cause a decrease in LC expression of MHC class II molecules, thus antigen presentation in association with these molecules is impaired.…”

Section: A Case Of Multiple Basal Cell Carcinomas In An Immunocomprom...mentioning

confidence: 99%

“…These alterations cause a decrease in LC expression of MHC class II molecules, thus antigen presentation in association with these molecules is impaired. 5,7 Furthermore, chronic lymphoedema has been shown to cause proangiogenic factors increase, in particular vascular endothelial growth factor (VEGF), which promotes skin carcinogenesis by altering cell growth and proliferation. 4,5 In literature, cases of basal cell carcinomas in immunocompromised districts caused by secondary lymphoedema have already been described 5,8,9 ; however, this would be the first reported case of three basal cell carcinomas arising from an ICD after a primary lymphoedema simultaneously.…”

Section: A Case Of Multiple Basal Cell Carcinomas In An Immunocomprom...mentioning

confidence: 99%

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A case of multiple basal cell carcinomas in an immunocompromised skin district: The aetiopathogenetic role of congenital lymphqedema

et al. 2023

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Kaposi Sarcoma in the Context of Post‐Modified Radical Mastectomy: A New Case Report and Brief Review

Genedy,

El Sayed

2024

J Cutan Pathol

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Kaposi sarcoma is a human herpesvirus 8–associated angio‐proliferative tumor arising from lymphatic endothelial cells. Four clinical subtypes are known: classic, epidemic, endemic, and iatrogenic. The development of Kaposi sarcoma and lymphedema may be interlinked, where each condition could potentially support the progression of the other. Post‐mastectomy lymphedema is a commonly recognized complication following radical mastectomy. Angiosarcoma is the most frequently reported neoplasm in such a situation. We present a 72‐year‐old female who developed Kaposi sarcoma on the same side of mastectomy 9 years following her initial diagnosis and treatment for cancer breast. The diagnosis of Kaposi sarcoma was based on the histopathologic findings and was confirmed with immunohistochemical staining for human herpes virus 8 and D2‐40. Lymphedema may be associated with local immune suppression manifested in the form of defective cell–mediated immunity and antigen‐presenting cell migration defect which may facilitate development of neoplasms. It is important to differentiate Kaposi sarcoma from other vascular tumors which may have a much worse prognosis. Patients with lymphedema should receive appropriate management and undergo long‐term follow‐up for early detection of any potential malignancies.

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Synchronous non-collision melanoma and basal cell carcinoma arising from chronic lymphedema: a case report and review of literature

Cited by 3 publications

References 9 publications

Giant Ulcerative Basal Cell Carcinoma with Local Metastasis: A Case Report and Assessment of Surgical Techniques

Giant Ulcerative Basal Cell Carcinoma with Local Metastasis: A Case Report and Assessment of Surgical Techniques

A case of multiple basal cell carcinomas in an immunocompromised skin district: The aetiopathogenetic role of congenital lymphqedema

Kaposi Sarcoma in the Context of Post‐Modified Radical Mastectomy: A New Case Report and Brief Review

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