Synchronous occurrence of gastrointestinal stromal tumor and intrahepatic cholangiocarcinoma: A case report

Abstract

Various cases of gastrointestinal stromal tumor (GIST) coinciding with other gastrointestinal malignancies have been reported to date, however, the synchronous occurrence of GIST and intrahepatic cholangiocarcinoma (ICC) is exceptionally rare and, to the best of our knowledge, has only been reported once. The coinciding malignancy has usually been encountered incidentally during surgical exploration. Thus, this is the first report where a targeted biopsy of the clinically suspicious lesion was used to determine the diagnosis of ICC concurrent with GIST. The liver is the most frequent metastatic site of GIST, therefore, additional hepatic masses may be mistakenly diagnosed as metastatic disease, rather than the presentation of multiple primary tumors. This subsequently delays the accurate diagnosis and complicates the performance of a curable resection. The current study reports a case of advanced synchronous GIST and ICC, which was operable at initial presentation, but progressed to become surgically unresectable.

Successful treatment of colorectal liver metastasis harboring intrahepatic cholangiocarcinoma

“…ICC occasionally coexists with other cancers, such as lymphoma, [5] renal cell carcinoma, [6] hepatocellular carcinoma, [7–9] thyroid cancer, [10] and gastrointestinal stromal tumors. [11] Only 2 reports are available in the literature about colorectal metastases with ICC; however, both diagnoses were delayed. [3,4]…”

Intrahepatic cholangiocarcinoma coinciding with a liver metastasis from a rectal carcinoma: a case report

“…Nam et al reported a case of advanced synchronous GIST and ICC, which was operable at initial presentation, but progressed to become surgically unresectable [9]. They concluded that the possibility of multiple primary tumors must be considered as an alternative diagnosis.…”

“…Synchronous cancers are defined as those where secondary tumors occur simultaneously or within 6 months of diagnosis of the primary malignancy [ 4 ]. ICC sometimes coexists with other cancers such as HCC [ 5 – 8 ], GIST [ 9 , 10 ], thyroid cancer [ 11 ], lymphoma [ 12 ], and renal cell carcinoma [ 13 ]. Only one case with synchronous double cancer consisting of combined HCC-ICC and metastasis of a colon adenocarcinoma, which were treated by curable resection, has been reported [ 1 ].…”

“…In our case, it was difficult to diagnose the ICC before hepatectomy because the CT scan showed that there were several tumors in the liver that were similar in shape. Nam et al reported a case of advanced synchronous GIST and ICC, which was operable at initial presentation, but progressed to become surgically unresectable [ 9 ]. They concluded that the possibility of multiple primary tumors must be considered as an alternative diagnosis.…”