Synchronous Occurrence of Mycosis Fungoides, Diffuse Large B Cell Lymphoma and Acute Myeloid Leukemia

Abstract

Patients with mycosis fungoides (MF), the most common subtype of primary cutaneous T-cell lymphoma, have an increased risk of developing secondary malignancies. We herein report two rare cases of MF concurring with diffuse large B cell lymphoma (B lymphoid lineage) and acute myeloid leukemia (myeloid lineage) in two otherwise healthy elderly patients. Potential etiologic factors, including the impact of the therapy-associated inflammatory response on the development of secondary tumors in patients with MF, are discussed. Further clinical, experimental and genetic studies are needed to elucidate possible physiopathogenic associations among the three concurrent malignancies occurring in the cases presented here.

Common origin of sequential cutaneous CD30+ lymphoproliferations with nodal involvement evidenced by genome‐wide clonal evolution

“…The present case appears to be quite singular, owing to the association of B-cell-lineage and T-cell-lineage tumours, which remains a rare phenomenon among composite lymphomas. 25 Such a combination is classically observed between DLBCL and MF, 26 and much more rarely between DLBCLs and other T-cell lymphomas. [27][28][29] Despite exceptional case reports of composite lymphomas associating CD30+ cutaneous lymphoproliferations with B-cell lymphomas, 30,31 the probability of concomitant nodal DLBCL and LyP seems to be extremely low, with only one case being reported in a recent large series.…”

Concurrent Subcutaneous Panniculitis-like T-Cell Lymphoma and B-Cell Acute Lymphoblastic Leukemia in 2 Pediatric Patients

“…For instance, mycosis fungoides has been associated with secondary malignancies, including B-cell lymphomas. Miyatake et al 18 hypothesize that the malignant T-cells promote immunodeficiency, and this environment may subsequently allow malignant clonal expansion. Patients with primary immunodeficiencies have significantly increased rates of B and T-ALL, 19,20 which suggests a possible role for immune surveillance in controlling malignant precursors.…”