Synchronous Onset of Symmetrically Associated Extragenital Lichen Sclerosus and Vitiligo on both Breasts and the Vulva

Vitiligoid variant of lichen sclerosus in young girls with darker skin types

“…Three case reports describe LS and vitiligo developing concurrently but in distinct skin locations, which is probably why the term vitiligoid LS was not used and the authors instead assigned both diagnoses. [5][6][7] It is possible that the distinct lesions appeared at the same time due to a common trigger, but the vitiligo lesions were not histologically evaluated in all cases, making definitive distinction between LS and vitiligo lesions difficult. One report described a patient with the onset of LS in the genital region that began after vitiligo spread to that area, suggesting the possibility of vitiligo exposing antigens, which led to the development of LS.…”

“…Reports of the synchronous onset of LS and vitiligo have supported the relationship between LS and vitiligo. Three case reports describe LS and vitiligo developing concurrently but in distinct skin locations, which is probably why the term vitiligoid LS was not used and the authors instead assigned both diagnoses . It is possible that the distinct lesions appeared at the same time due to a common trigger, but the vitiligo lesions were not histologically evaluated in all cases, making definitive distinction between LS and vitiligo lesions difficult.…”

“…Other reports have described a close relationship between the timing and location of LS and vitiligo presentation but do not categorize such lesions as vitiligoid LS, probably because the conditions occur on different areas of the skin in most cases. Such reports do not appear to be limited to darker‐skinned individuals . Previously described cases of vitiligo associated with LS might be better classified as vitiligoid LS if histologic analysis were available .…”

“…Such reports do not appear to be limited to darker-skinned individuals. [5][6][7][8] Previously described cases of vitiligo associated with LS might be better classified as vitiligoid LS if histologic analysis were available. 2 We present a case series of seven girls with darker skin types with the clinical overlap of vitiligo and LS in the anogenital region and seek to explore this confusing overlapping presentation further.…”

Frontal Fibrosing Alopecia and Autoimmune Disorders in a Hispanic Female

“…Genetic predisposition may also play a role in concomitant appearance [4,9]. Lichen sclerosus may also occur simultaneously with other autoimmune diseases, like vitiligo [10]. Chronic inflammation seen in these entities could explain the coexistence of diseases in the same location.…”