Synchronous Papillary Carcinoma of Thyroid and Lung

Wang, Tao; Blumer, Ian; Boerner, Scott; Sylvia, L.

doi:10.1007/s12022-016-9435-6

Cited by 1 publication

(1 citation statement)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thyroid cancer therapy is based on surgery followed by iodine-131 treatment to avoid potential tumor remnants and metastases. Clinicopathological factors including age, sex, tumor size and lymphadenopathy are risk factors of PTC progression ( 5 ). Lymph node metastasis is common in patients with PTC, and it has been identified in 20–50% of patients prior to the initial treatment of PTC ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Association of the characteristics of B‑ and T‑cell repertoires with papillary thyroid carcinoma

et al. 2018

View full text Add to dashboard Cite

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Complementarity-determining region 3 (CDR3) of B-cell receptors (BCRs) and T-cell receptors are the major site of antigen recognition, which determines a unique clone type, and are considered to be the representative of the disease. In the present study, high-throughput sequencing was used to analyze the association of characteristics of the BCR immunoglobulin heavy chain (IGH) and the T-cell receptor β chain (TRB) CDR3 genes in PTC and corresponding pericarcinous tissues from patients. A difference of CDR3 length distributions of total IGH CDR3 sequences between the two groups was revealed. IGHV3-11/IGHJ6, TRBV2/TRBJ1-2 and TRBV2/TRBJ1-1 may be biomarkers for the development of PTC. Furthermore, it was revealed that the extent of the common clonotype expressions at the amino acid level was slightly higher compared with the nucleotide level. The Shannon entropy demonstrated a diversity reduction in PTC compared with the pericarcinous group, and the highly expended clone (HEC) expression of PTC was higher compared with that of the corresponding pericarcinous group. Additionally, the highest clone frequency percentage of IGH and TRB was at 0.1–1.0% degree of expansion, as HEC expression was higher in PTC compared with the matched group. There was no shared clone of HECs in the two groups either at the amino acid level or at the nucleotide expression level. The differential expression of CDR3 sequences of PTC have been identified in the present study. Further research is required for assessing the immune repertoire size, diversity, cloning tracking and finding public clones of T-cell and B-cell populations in the development of PTC.

show abstract

Section: Introductionmentioning

confidence: 99%