Synchronous pituitary adenoma and pituicytoma

Correlations between clinical hormone change and pathological features of pituicytoma

“…Given the association between pituicytoma and the hormonal change that is induced in the affected pituitary gland region, we argue that pituicytoma could trigger pituitary gland cell proliferation and transformation into pituitary adenoma. However, because of the differences between our patient (who presented with Cushing disease) and the patient described by Marian et al 28 (who presented with no endocrine dysfunction), the chronological order of glandular hyperactivity and adenoma transformation is uncertain.…”

“…27 There is only one reported case of synchronous pituitary adenoma and pituicytoma, which was described by Marian et al in 2016. 28 The patient presented with a 6-month history of increasing visual impairment and headaches; no symptoms of endocrine dysfunction were noted and no association between the two tumours was disclosed following a histopathological exam and DNA methylation profiling. 28 In the present study, one patient with Cushing disease was found to have coexisting pituicytoma and ACTH adenoma.…”

“…28 The patient presented with a 6-month history of increasing visual impairment and headaches; no symptoms of endocrine dysfunction were noted and no association between the two tumours was disclosed following a histopathological exam and DNA methylation profiling. 28 In the present study, one patient with Cushing disease was found to have coexisting pituicytoma and ACTH adenoma. Given the association between pituicytoma and the hormonal change that is induced in the affected pituitary gland region, we argue that pituicytoma could trigger pituitary gland cell proliferation and transformation into pituitary adenoma.…”

A 53‐year‐old woman with Cushing's disease and a pituitary tumor

“…However, origin from a common precursor cell seems to be unlikely due to the different biomolecular profile recently demonstrated in these two entities. 14 In conclusion, the present case shows that pituicytoma may occur in the clinical setting of Cushing's disease. Whether this tumor may itself represents the cause of ACTH hypersecretion in patients with undetected pituitary adenoma still remains to be investigated.…”

“…Association of pituicytoma and pituitary adenoma needs further investigation. However, origin from a common precursor cell seems to be unlikely due to the different biomolecular profile recently demonstrated in these two entities …”