Synchronous Presence of Nasopharyngeal Carcinoma and Marginal Zone (MALT-Type) B-Cell Lymphoma  in the Pharynx

Κoletsa, Triantafyllia; Petrakis, Georgios; Karayannopoulou, Georgia; Pappas, Dimitrios; Markou, Konstantinos; Karkavelas, Georgios; Kostopoulos, Ioannis

doi:10.4061/2011/340763

Cited by 7 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Synchronous squamous cell carcinoma in the head and neck region and malignant lymphoma is rare and few have been reported. [24][25][26][27] In our retrospective analysis, 0.04% patients of all malignancies in the head and neck region had synchronous malignant lymphoma. Clinical suspicion of enlarged lymph nodes of the neck is crucial in the differentiation and diagnosis of lymphoma with that of a secondary neck node, so the awareness of this association is crucial for the correct management of this small group of patients.…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary cancers of the head and neck region and upper aero digestive tract: Defining high-risk patients

et al. 2013

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Synchronous primary cancers of the head and neck region and upper aero digestive tract: Defining high-risk patients

et al. 2013

View full text Add to dashboard Cite

show abstract

“…1). [12–262] The data were extracted from the abstract in 34 articles, [17,37–39,64,75,76,78,81,94,97,103,129,134,151,162,166,170,174,176,192,195,212,221,222,229,232,234,251,252,256,260–262] of which 21 were in English, 5 in Japanese, 3 in Spanish, 2 in French, 2 in Chinese, and 1 in Czech.…”

Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

View full text Add to dashboard Cite

Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

show abstract

“…According to the previous studies, cases of synchronous lymphoma and other neoplasms in the same organ showed involvement in stomach, thyroid, kidney, throat, and tonsils. [ 10 , 19 – 21 ] Rare studies have been published on cases showing lymphoma and carcinoma in the lung tissues.…”

Section: Discussionmentioning

confidence: 99%

Synchronous primary pulmonary adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

Sun

Zhang

Ke³

et al. 2020

Medicine

View full text Add to dashboard Cite

Rationale: Synchronous pulmonary lymphoma and carcinoma is relatively rare. And synchronous pulmonary lymphoma and adenocarcinoma in the same site is extremely rare. Patient concerns: We presented a 69-year-old female with a tumor mass in right upper lung. Diagnosis: Pathological and immunohistochemical findings revealed lung adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue. Interventions: The patient received thoracoscopic guided right upper lobectomy and focal lymph node dissection after systemic anesthesia. Besides, 6 cycles of chemotherapy were given based on meprednisone, gemcitabine and cisplatin in local hospital. Outcomes: In the 12-month follow-up, the patient was still alive with no local recurrence, metastasis and lymph node involvement. Lesson: A comprehensive literature research was performed, and 6 cases of synchronous pulmonary lymphoma and adenocarcinoma in the same site and 10 cases in different sites were identified since 2000. Most patients with synchronous pulmonary lymphoma and carcinoma were middle-aged and elderly with the median age was 64 years presenting a male predisposition. The most frequent type of primary pulmonary lymphoma was B-cell non Hodgkin lymphoma, especially mucosa-associated lymphoid tissue lymphoma, and the lung cancer is predominantly adenocarcinoma.

show abstract

Synchronous Presence of Nasopharyngeal Carcinoma and Marginal Zone (MALT-Type) B-Cell Lymphoma in the Pharynx

Cited by 7 publications

References 18 publications

Synchronous primary cancers of the head and neck region and upper aero digestive tract: Defining high-risk patients

Synchronous primary cancers of the head and neck region and upper aero digestive tract: Defining high-risk patients

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous primary pulmonary adenocarcinoma and extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue

Contact Info

Product

Resources

About