Synchronous Primary Hepatic Lymphoma and Epidermoid Lung Carcinoma Treated with Chemotherapy and Surgery

Graziano, Francesco; Cellerino, R; Menestrina, Fabio; Nicoli, N; Gramazio, Attilio; Latini, Luciano; Piga, Andrea

doi:10.1097/00000421-199506000-00003

Cited by 9 publications

(4 citation statements)

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“…1). [12–262] The data were extracted from the abstract in 34 articles, [17,37–39,64,75,76,78,81,94,97,103,129,134,151,162,166,170,174,176,192,195,212,221,222,229,232,234,251,252,256,260–262] of which 21 were in English, 5 in Japanese, 3 in Spanish, 2 in French, 2 in Chinese, and 1 in Czech.…”

Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

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Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

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“…It has been reported that complete remission of both diseases could be achieved with a radical approach which comprised of chemotherapy and surgery [ 13 ]. The overall survival depends mainly on the stage of lung carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Small lymphocytic lymphoma and lung malignancy coincidence in a male patient: a case report and literature review

Kakos¹,

Geropoulos

Loufopoulos

et al. 2021

Journal of Surgical Case Reports

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Lung carcinoma management secondary to chronic lymphocytic leukemia could be quite challenging. We report a case of a 60-year-old male with several co-morbidities, who presented with shortness of breath and persistent cough. A chest imaging showed a right pleural effusion and complete white-out of the right chest cavity. A computed tomography scan revealed consolidation of the right upper lobe with a 6-cm lesion in hilum with complete occlusion of right lobe bronchus. The patient underwent a video-assisted thoracoscopic surgery, drainage of pleural effusion and pleural and lung biopsy. Talc pleurodesis as well as a flexible bronchoscopy of the endobronchial lesion was performed. Histopathological examination showed a small B-cell lymphoma of the right pleura and an invasive non-small cell carcinoma of the right lung. Dual neoplasms are challenging in terms of diagnosing, and they usually require a multidisciplinary team for the right treatment strategy, including surgery and chemotherapy.

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“…Numerous authors reported about the synchronous occurrence of NHL and renal, hepatic or intestinal carcinomas [1,2,4,5,6]. Travis et al reported that the increased number of renal cell cancers less than 1 year after diagnosis of NHL was likely due to early detection by procedures used in the diagnosis, staging, and subsequent evaluation of NHL response [3].…”

Section: Commentmentioning

confidence: 99%

“…The treatment of both tumors is still under discussion. It has been reported that complete remission of both diseases was achieved with a radical approach, which included combination chemotherapy and surgery [5,6]. Treatment of synchronous esophageal carcinoma and NHL with three cycles of the CHOP regime for NHL and to maintain a static state of esophageal cancer, followed by short-course high-dose locoregional radiation ther- apy and surgical resection was reported by Ramesh and co-workers [6].…”

Section: Commentmentioning

confidence: 99%

Coexistence of Non-Hodgkin’s Lymphoma and Non-Small-Cell Lung Carcinoma: Diagnosis and Treatment

Rothenburger

Semik

Hoffmeier

et al. 2002

Thorac cardiovasc Surg

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Abstract. In this communication, we will present a very rare case of the coexistence of non-Hodgkin's lymphoma (NHL; low malignant lymphocytic lymphoma of the B-cell type) and a non-small-cell lung carcinoma (NSCLC). A patient with a 15-year history of NHL developed a generalized relapse of the lymphoma with an additional tumor mass in the left lower lobe of the lung. Bronchoscopy showed the evidence of the NHL. Due to non-responding chemotherapy on the lung tumor, the coexistence of a second malignancy was histologically proved in a second bronchoscopy. Resection of the lung tumor with complex lobectomy and lymphadenectomy was performed. After that, chemotherapy with four cycles of carboplatin supplemented with taxol was induced. The patient was discharged from the hospital with a stable remission of both tumor diseases. Restaging after six months showed no evidence of a tumor relapse. This is a very rare case of the coexistence of NHL and NSCLC; we will discuss the difficulty of diagnostic and treatment of both tumor diseases.

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Synchronous Primary Hepatic Lymphoma and Epidermoid Lung Carcinoma Treated with Chemotherapy and Surgery

Cited by 9 publications

References 0 publications

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Small lymphocytic lymphoma and lung malignancy coincidence in a male patient: a case report and literature review

Coexistence of Non-Hodgkin’s Lymphoma and Non-Small-Cell Lung Carcinoma: Diagnosis and Treatment

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