Synchronous Primary Low-grade Mucosa-associated Lymphoid Tissue Lymphoma of Colon and Stomach

Jeong, Ji Hyun; Koo, Hoon Sup; Kang, Min Gyu; Na, Woon Tae; Lim, Dong Mee; Huh, Kyu Chan

doi:10.5217/ir.2013.11.3.204

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…[ 10 ] However, it can present with nonspecific gastrointestinal symptoms such as abdominal pain, weight loss, diarrhea, constipation, mucoid stool, hematochezia, and sometimes obstruction. [ 11 , 12 ] On the colonoscopy, single lesion or multinodular polypoid lesions are most common, followed by a subepithelial tumor, flat elevation, mucosal edema, erythema, and loss of vascularity. [ 13 , 14 ] Previously, Jeon et al [ 15 ] classified colorectal MALT lymphomas into 4 endoscopic subtypes based on retrospective clinical data: polyposis, epithelial mass, ileitis, and subepithelial tumor, which is the most common endoscopic type.…”

Section: Discussionmentioning

confidence: 99%

A case of colonic MALT lymphoma with intra-abdominal abscess and lung metastasis: A case report

Lee,

Jung

et al. 2023

Medicine

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Rationale: Colonic mucosa-associated lymphoid tissue (MALT) lymphoma is an unusual subtype comprising only 2.5% of all MALT lymphomas. Most cases of colonic MALT lymphoma are diagnosed at an early stage. Therefore, the clinical features of advanced-stage colonic MALT lymphoma have seldom been reported, and the endoscopic findings are not well established. In this study, we report the clinical and endoscopic characteristics of stage IV colonic MALT lymphoma and highlight the importance of repeat biopsy to figure out this rare disease. Patient concerns: The patient was a 68-year-old male complaining of hematochezia and lower left quadrant abdominal pain for the past 3 days. Diagnoses: The patient had 3 masses and friable mucosal lesions in the colon. With the first colonoscopy and biopsy, he was initially diagnosed as having eosinophilic colitis. However, the first treatment with steroids did not show any response. Because of atypical clinical features and colonoscopic findings, a second colonoscopy and a repeat biopsy were performed, and the results were consistent with colonic MALT lymphoma arising in the colon. The patient was finally diagnosed with stage IV colonic MALT lymphoma accompanied by multiple distant metastases. Interventions and outcomes: The patient started to receive chemotherapy with a combination regimen of cyclophosphamide, vincristine, and prednisolone. The follow-up study after 3 months showed stable disease status based on response evaluation criteria in solid tumors. Lessons: This case report presents atypical clinical characteristics and colonoscopic findings of stage IV colonic MALT lymphoma. Clinical suspicion and repeat biopsy should be considered to diagnose this rare and diagnostically challenging cancer.

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Section: Discussionmentioning

confidence: 99%

A case of colonic MALT lymphoma with intra-abdominal abscess and lung metastasis: A case report

Lee,

Jung

et al. 2023

Medicine

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“…Although MALTomas themselves are not uncommon, the presence of synchronous upper and lower GI MALTomas appears to be a more rare occurrence, with only a few cases reported [ 2 , 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Synchronous Upper and Lower Gastrointestinal Mucosa-Associated Lymphoid Tissue Lymphomas

McFarlane

Wong

Paneesha

et al. 2016

Case Rep Gastroenterol

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Mucosa-associated lymphoid tissue lymphoma (MALToma) is a subtype of B-cell non-Hodgkin’s lymphoma, comprising ∼17% of all gastrointestinal (GI) tract lymphomas. It is associated with chronic inflammation and autoimmunity, for example Helicobacter pylori gastritis and Sjogren’s syndrome, respectively. Approximately 50% of GI MALTomas occur in the stomach, with small bowel and colonic lesions being less frequent. Synchronous upper and lower GI MALTomas occur rarely, with few cases reported. We present the case of a 73-year-old patient who presented with change in bowel habit and was found to have synchronous multifocal upper and lower GI MALTomas, which did not respond to H. pylori cure or to rituximab therapy, but did respond to a combination of surgery and chemotherapy with rituximab and bendamustine.

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“…Non-GI sites of MALToma include the lungs, salivary glands, thyroid gland, skin, and eyes. The presence of synchronous upper and lower GI MALTomas appears to be an extremely rare occurrence, with only a few cases reported [ 1 , 2 , 3 ]. This is the first report involving four separate synchronous MALTomas in the upper and lower GI tract.…”

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confidence: 99%

Multiple Synchronous Mucosa-Associated Lymphoid Lymphomas Involving in the Stomach, Duodenum, Ileum, and Sigmoid

Chen

2022

Diagnostics

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Gastric MALToma is an extra-nodal marginal-type B-cell lymphoma. MALToma may occur secondary to chronic inflammation and autoimmunity. The most common gastrointestinal (GI) site of MALToma is the stomach, with approximately 50% of lesions occurring there. Synchronous upper and lower GI MALTomas rarely occur, with few cases reported. We present the case of a 67-year-old patient who presented asymptomatic and was found to have synchronous multifocal upper and lower GI MALTomas in the stomach, duodenum, terminal ileum, and sigmoid, which did not respond to H. Pylori eradication therapy.

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Synchronous Primary Low-grade Mucosa-associated Lymphoid Tissue Lymphoma of Colon and Stomach

Cited by 6 publications

References 13 publications

A case of colonic MALT lymphoma with intra-abdominal abscess and lung metastasis: A case report

A case of colonic MALT lymphoma with intra-abdominal abscess and lung metastasis: A case report

Synchronous Upper and Lower Gastrointestinal Mucosa-Associated Lymphoid Tissue Lymphomas

Multiple Synchronous Mucosa-Associated Lymphoid Lymphomas Involving in the Stomach, Duodenum, Ileum, and Sigmoid

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