Synchronous Primary Ovarian and Endometrial Cancer With a Fair Prognosis in a Young Woman

Lin, Michael C.; Yang, Yu-Hsuan; Chen, Ruey-Jien; Cheng, Shao-Pei; Chang, Tong‐Bou

doi:10.1016/s1028-4559(10)60019-8

Cited by 7 publications

(2 citation statements)

References 9 publications

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“…When the pathologic study reveals similar types, the differentiation between the 2 separate primary cancers or 1 single advanced cancer with metastasis is much more difficult. Herein, we apply standardized criteria to differentiate the 2 synchronous cancers, rather than 1 cancer metastases [(1) both tumors are confined to primary sites; (2) no direct extension between the tumors; (3) no lymphovascular tumor emboli; (4) no or only superficial myometrial invasion of the endometrial lesion; and (5) no distant metastasis] [ 4 , 5 ].…”

Section: Methodsmentioning

confidence: 99%

Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

Zhao

Wang

et al. 2017

J Ovarian Res

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BackgroundThis study aimed to identify the clinical and pathological characteristics and the possible prognostic factors for Chinese patients with early-stage ovarian endometrioid carcinoma.MethodsThe present study reviewed the medical records of patients who received initial treatment and a postoperative pathological diagnosis of ovarian endometrioid carcinoma at our center. In all, 78 patients had stage I ovarian endometrioid carcinoma.ResultsIn this series, the 5-year overall survival rate and 5-year disease-free survival (DFS) rates of patients with stage I ovarian endometrioid carcinoma was 98.7% and 87.2%, respectively. Univariate analysis showed the factors that influence the DFS rates include menopausal status, FIGO stage, histological grade, lymphadenectomy, cytology of ascites. Multivariate analysis showed that grade 3 and lymphadenectomy were the independent prognostic factors of DFS for Stage I ovarian endometrioid carcinoma (P = 0.0259, 0.0276 respectively). However, the coexisting endometriosis, concomitant endometrial disorders, dissection of para-aortic lymph node and more courses of thermotherapy had no influence on DFS. Besides, it was found that 19.3% of patients in this series had synchronous early stage and well-to-moderate differentiated endometrial carcinoma.ConclusionsGrade 3 and lymphadenectomy were indicated as the independent factors of DFS for stage I patients with ovarian endometrioid carcinoma. The endometrial changes should be considered seriously when fertility-sparing surgery was planned.

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Section: Methodsmentioning

confidence: 99%

Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

Zhao

Wang

et al. 2017

J Ovarian Res

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Section: Methodsmentioning

confidence: 99%

Endometriosis is the independent prognostic factor for survival in Chinese patients with epithelial ovarian carcinoma

Ren¹,

Wang²,

Sun³

et al. 2017

J Ovarian Res

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BackgroundClinico-pathological characteristics and possible prognostic factors among women with epithelial ovarian carcinoma (EOC) with or without concurrent endometriosis were explored.MethodWe retrospectively identified 304 patients with EOC treated primarily at Peking Union Medical College Hospital with median follow-up time of 60 months.ResultsOf 304 patients with EOC, concurrent endometriosis was identified in 69 (22.7%). The patients with concurrent endometriosis were younger and more probably post-menopausal at onset, were less likely to have abdominal distension, with significantly lower level of pre-surgery serum Ca125 and less possibility of having the history of tubal ligation. The women with concurrent endometriosis group were more likely to have early stage tumors (88.41% versus 52.77%), receive optimal cytoreductive surgery (92.75% versus 71.06%), and less likely to have lymph node metastasis or to develop platinum resistance disease (7.25% versus 14.89%, and 7.35% versus 20%), when compared with women without coexisting endometriosis. The univariate analysis showed that concurrent endometriosis was a prognostic factor for overall survival (OS) and disease-free survival (DFS), but this association just remained in the DFS by multivariate analysis. Besides, multivariate analysis also showed that FIGO stage, residual disease, chemotherapy cycles, chemotherapy resistance and concomitant hypertension were the independent impact factors of OS for EOC patients; whereas FIGO stage, lymphadenectomy, residual disease, coexisting endometriosis and chemoresistance were independent impact factors of DFS for those patients.ConclusionsEOC patients with concurrent endometriosis showed distinct characteristics and had longer overall survival and disease-free survival when compared with those without endometriosis. Endometriosis was the independent prognostic factor for DFS for patients in this series.

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Prognostic analysis of endometrioid epithelial ovarian cancer with or without endometriosis: a 12-year cohort study of Chinese patients

Wang

Qiu

Lang

et al. 2013

American Journal of Obstetrics and Gynecology

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Synchronous Primary Ovarian and Endometrial Cancer With a Fair Prognosis in a Young Woman

Cited by 7 publications

References 9 publications

Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

Prognostic analysis for Chinese patients with stage I ovarian endometrioid carcinoma

Endometriosis is the independent prognostic factor for survival in Chinese patients with epithelial ovarian carcinoma

Prognostic analysis of endometrioid epithelial ovarian cancer with or without endometriosis: a 12-year cohort study of Chinese patients

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