Synchronous Renal Cell Carcinoma and Gastrointestinal Malignancies

Abstract

While renal cell carcinoma is the most commonly diagnosed neoplasm of the kidney, its simultaneous diagnosis with a gastrointestinal malignancy is a rare, but well reported phenomenon. This discussion focuses on three independent cases in which each patient was diagnosed with renal cell carcinoma and a unique synchronous gastrointestinal malignancy. Case 1 explores the diagnosis and surgical intervention of a 66-year-old male patient synchronously diagnosed with clear cell renal cell carcinoma and a carcinoid tumor of the small bowel. Case 2 describes the diagnosis and surgical intervention of a 61-year-old male found to have clear cell renal cell carcinoma and a mucinous appendiceal neoplasm. Lastly, Case 3 focuses on the interventions and management of a 36-year-old female diagnosed with synchronous clear cell renal carcinoma and hereditary nonpolyposis colorectal cancer. This case series examines each distinct patient's presentation, discusses the diagnosis, and compares and contrasts the findings while discussing the literature on this topic.

Vision Loss from Choroidal and Pituitary Metastases Secondary to Renal Cell Carcinoma: A Case Report

“…Renal cell carcinoma (RCC) is the most common neoplasm of the kidney, accounting for 3.8% of all new cancer diagnoses made annually in the United States. 1 There are many different subtypes of RCC, with clear cell RCC (ccRCC) being the most common, occurring in 88% of over 4000 patients in a retrospective review. 2 Out of the top three most common RCC histological subtypes, patients with ccRCC have the worst prognosis with 5 year disease specific survival rates of 54.9-68.9%.…”

Surgical Treatment of Synchronous Colorectal and Renal Neoplasms

“…Patients diagnosed with colo- rectal carcinoma (CRC) are at a higher risk for renal cell carcinoma (RCC) compared to the general population, and vice versa (2). It has been suggested that both neoplasms are associated with genetic predisposition and share common pathogenetic mechanism (1)(2)(3)(4)(5). Synchronous tumors are believed to originate from tissues and organs of similar embryonic origin (5,6).…”

“…It has been suggested that both neoplasms are associated with genetic predisposition and share common pathogenetic mechanism (1)(2)(3)(4)(5). Synchronous tumors are believed to originate from tissues and organs of similar embryonic origin (5,6). Environmental factors (tobacco smoke, pollution, ultraviolet light, chemo-and radiotherapy, endocrine factors) may also play an important role in the development of these malignancies (5,6).…”

“…Synchronous tumors are believed to originate from tissues and organs of similar embryonic origin (5,6). Environmental factors (tobacco smoke, pollution, ultraviolet light, chemo-and radiotherapy, endocrine factors) may also play an important role in the development of these malignancies (5,6). In almost all of the described operable cases, the synchronous tumor was incidentally found in the setting of diagnostic imaging: ultrasonography, CT, MRI, PET/CT.…”

“…In almost all of the described operable cases, the synchronous tumor was incidentally found in the setting of diagnostic imaging: ultrasonography, CT, MRI, PET/CT. Thus, one should keep in mind the potentiality of encountering synchronous second tumor, while performing staging imaging (5). In many ways it is appropriate to use one-stage surgical approach for the simultaneous removal of the neoplasms,since it does not require a second surgical intervention and anesthesia.…”