Synchronous Two-Stage Hepatectomy With Associated Liver Partition and Portal Vein Ligation in Addition to Low Anterior Resection for Metastatic Rectal Cancer

Abstract

The associating liver partition and portal vein ligation for a staged hepatectomy (ALPPS) procedure is an excellent treatment strategy for patients with advanced primary or metastatic liver cancer and small liver remnants. This report discusses the surgical management of a 51-year-old male who was diagnosed with stage IV rectal cancer with multiple heterogeneous hypoenhancing solid masses seen in both lobes of the liver consistent with metastatic disease. He completed six cycles of preoperative FOLFOX chemotherapy with Avastin. Follow-up imaging demonstrated a good response. A combined low anterior resection and two-stage hepatectomy with ALPPS were discussed with the patient who agreed to proceed with the plan. He underwent a combined open low anterior resection with colorectal anastomosis in addition to the first stage of ALPPS. The patient tolerated the procedure well, and the immediate postoperative period was uncomplicated. Volumetric assessment of the left hepatic lobe on postoperative day seven demonstrated 26.7% of the original liver volume. The decision was made to take the patient back to the operating room on postoperative day nine for completion of the ALPPS, which entailed a total right hepatectomy. He tolerated the procedure well and was discharged home on postoperative day 16. No complications from the surgical procedure were reported on subsequent follow-up visits.

Liver Venous Deprivation for Rapid Liver Hypertrophy Before Major Hepatectomy: A Case Report

“…4 Over the last decade, associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has become a popular strategy for inducing rapid hypertrophy of the FLR before major hepatectomy. 5,6 However, it is associated with high morbidity and mortality. 7,8…”

“…4 Over the last decade, associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has become a popular strategy for inducing rapid hypertrophy of the FLR before major hepatectomy. 5,6 However, it is associated with high morbidity and mortality. 7,8 Liver venous deprivation (LVD) has emerged as a new endovascular technique to induce rapid hypertrophy of the FLR with a safety profile like conventional PVE and yet with faster FLR hypertrophy.…”