To determine the permissibility of piloting an aircraft with vasovagal syncope VVS is a complex responsibility, because it is dif cult to evaluate VVS quantitatively. There are no clear guidelines for aircraft pilots with VVS. In some facilities, Head-up Tilt Test HUTT is used to determine its reproducibility and treatment effect. In most cases, permission is dependent on the strict examinations by specialists and judgement of the committee established for each country. Therefore, we assessed pilots with VVS and designed an algorism of permission for piloting an aircraft. Here, we describe 7 consecutive regular passenger aircraft pilots with VVS who were restricted to y. All patients were men and their mean age was 37 years. All pilots were permitted to y after at least two or more tilt-tests. The observation period was two years after ight permission. None of the pilots in the present study fainted after receiving ight permission. We can make a risk strati cation to determine hypotensive susceptibility by multiple tilt tests. Based on the results of multiple HUTT, we can more quantitatively make the judgement as to whether the pilot s VVS is well managed.