Syndrome d’apnées obstructives du sommeil et cognition : une revue

Daurat, Agnès; Sarhane, Majdouline; Tiberge, M.

doi:10.1016/j.neucli.2016.04.002

Cited by 27 publications

(4 citation statements)

References 127 publications

(286 reference statements)

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“…On the D2 Test of attention, OSA patients had lower TN, TN-E, and CP scores but with higher E, E1, E2, and FR scores than con-trol group. This was consistent with earlier studies of Daurat et al [38] which showed moderate to severe attention maintenance deficits and D2 performance impairments possibly referred to fragmented sleep and excessive daytime sleepiness.…”

Section: Smrsupporting

confidence: 93%

Assessment of Cerebral Hypoxemia and Its Impact on Cognitive and Psychological Functions in Patients With Obstructive Sleep Apnea Syndrome

Badr,

Elkholy,

Abohamer

et al. 2023

Sleep Med Res

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Background and Objective The precise pathophysiology of cognitive impedance and mental illness in obstructive sleep apnea (OSA) patients remains elusive. Therefore, there is a need for studies on novel diagnoses and therapeutic strategies for cognitive impairment in OSA patients. This work aimed to evaluate cerebral hypoxemia, its consequences on brain metabolism, and local and systemic inflammation, and their subsequent impact on cognitive and psychological functioning.Methods This cross-sectional case-control study was conducted on 30 eligible OSA patients and 20 age/sex-matched healthy controls. All the participants underwent one-night polysomnography, and cognitive evaluation was done using the Mini-Mental State Examination, Montreal Cognitive Assessment, Brief Kingston Standardized Cognitive Assessment, D2 Test of Consideration (to evaluate attention problems), and Wisconsin card sorting test. The psychiatric assessment included the Arabic form of the Hamilton Depression Rating Scale and Beck Depression Inventory-II. A radiology assessment was done using proton magnetic resonance spectroscopy. Neurophysiological assessment was done using the potential cortical (N20) latency and amplitude of somatosensory evoked potential. Laboratory examinations included serum levels of NF-κB, HMGB1, and HIF-1α.Results Polysomnography demonstrated noteworthy increase in the apnea-hypopnea index, respiratory disturbance index, arousal index, snoring index, and wake after sleep onset. It also showed diminished sleep efficiency, total sleep time, and SaO2 nadir in the OSA group. Neuropsychological scales demonstrated poor performance in global cognitive tests, particular cognitive domains impedance, and depression in the OSA group, with noteworthy differences within the group. Magnetic resonance spectroscopy highlighted that OSA patients had a noteworthy bilateral decrement in N-acetylaspartate (NAA) peak, creatine peak, and NAA/choline proportion and an increment in choline peak, lipid peak, lactate peak, choline/creatine proportion, and NAA/creatine proportion in the frontal white matter, hippocampus, and parieto-occipital cortex. Moreover. OSA patients had either missing or decreased amplitude and delayed latency of N20. There was a noteworthy rise of serum inflammatory marker NF-κB, HMGB1, and oxidative stress marker HIF-1α in OSA patients.Conclusions Chronic intermittent hypoxia with resulting amplified inflammatory and oxidative stress in OSA patients may affect brain metabolism; consequently, leading to cognitive and psychological dysfunctions.

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Section: Smrsupporting

confidence: 93%

Assessment of Cerebral Hypoxemia and Its Impact on Cognitive and Psychological Functions in Patients With Obstructive Sleep Apnea Syndrome

Badr,

Elkholy,

Abohamer

et al. 2023

Sleep Med Res

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“…Increased p53 and decreased Bcl-2 ultimately results in increased apoptosis of the essential brain cells under SAE conditions. Neuronal apoptosis can result in brain atrophy (especially in the cortex and hippocampus) and ventricle enlargement [81], fi-nally leading to cognitive impairment. Of course, activation of mitogen activated protein kinase (MAPK) [82,83] and mechanistic target of rapamycin (mTOR) signaling pathways [84] produce apoptotic factors as a result of neuroinflammation.…”

Section: Discussionmentioning

confidence: 99%

Environmental Enrichment Protects Against Cognition Deficits Caused by Sepsis-Associated Encephalopathy

Tang¹,

Duan²,

Ge³

et al. 2022

J. Integr. Neurosci.

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Background: One of the most serious complications of sepsis is sepsis-associated encephalopathy (SAE), which impairs the cognition ability of survivors. Environmental enrichment (EE) has been demonstrated to alleviate cognition deficits under many kinds of brain injury conditions. However, EE's effects on SAE remain unknown. Therefore, this study aimed to determine EE's effect on cognition disorders under SAE conditions and the underlying mechanism. Materials and Methods: Adult male rats, subject to SAE or not, were housed under a standard environment (SE) or EE for 30 days. Subsequently, the rats were subjected to cognitive tests, such as the novel object recognition (NOR) test, the Morris water maze (MWM) test, an Open Field (OF) test, the elevated plus maze (EPM) test, and a sensory neglect (SN) test. Neuroinflammation, apoptosis, and oxidative stress changes in the brain were also detected. Results: The results revealed that SAE impaired somatesthesia, recognition memory, spatial learning and memory, and exploratory activity, which were significantly improved by EE housing. EE also prevented SAE-induced anxiety-like behavior. In addition, EE housing capable induced a decrease in pro-inflammatory cytokines, and an increase in anti-inflammatory cytokines and antioxidant properties in the brain. Moreover, EE housing exerted an anti-apoptosis function by upregulating the level of B-cell lymphoma/leukemia-2 (Bcl-2) level and downregulating the level of p53 level in the hippocampus. Conclusions: The results of the present study indicated that EE exerts a neuroprotective function on cognitive ability in SAE rats. The effect is achieved by increasing antioxidants, and anti-inflammatory and antiapoptotic capacities. EE can effectively rescue SAE-induced cognitive deficits.

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“…OSA, mainly caused by obstructions of the upper airway, is characterized by repetitive episodes of shallow and paused breathing during sleep [77,78]. OSA leads to reduced blood oxygen saturation, snoring, arousal during sleep, and fatigue during the daytime.…”

Section: Obstructive Sleep Apnea Syndrome (Osa)mentioning

confidence: 99%

Factors influencing breath analysis results in patients with diabetes mellitus

et al. 2019

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Breath analysis is used to detect the composition of exhaled gas. As a quick and non-invasive detection method, breath analysis provides deep insights into the progression of various kinds of diseases, especially those with metabolism disorders. Abundant information on volatile compounds in diabetic patients has been studied in numerous articles in the literature. However, exhaled gas in diabetic patients can be altered by various complications. So far, little attention has been paid to this alteration. In our paper, we found that under air pollution conditions, diabetic patients exhale more nitric oxide. Diabetic patients with heart failure exhale more acetone than those without heart failure. After 13 C-labeled glucose intake, patients infected with Helicobacter pylori exhaled more 13 C and less 18 O than those without infection. Exhalation with chronic kidney disease changes volatile organic compounds on a large scale. Diabetic patients with ketoacidosis exhale more acetone than those without ketoacidosis. Some specific volatile organic compounds also emanate from diabetic feet. By monitoring breath frequency, diabetic patients with obstructive sleep apnea syndrome exhibit a unique breath pattern and rhythm as compared with other diabetic patients, and sleep apnea is prevalent among diabetic patients. In addition to clinical findings, we analyzed the underlying mechanisms at the levels of molecules, cells and whole bodies, and provided suggestions for further studies. List of abbreviations HpHelicobacter pylori T2DMType 2 diabetes mellitus HbA1c Glycosylated hemoglobin A1c FeNO Fraction of exhaled nitric oxide PM Particulate matter NO 2 Nitrogen dioxide SO 2 Sulfur dioxide NOx Nitrogen oxide CO 2 Carbon dioxide GC-MS Gas chromatography-mass spectrometry DM Diabetes mellitus VOCs Volatile organic compounds CKD Chronic kidney disease COPD Chronic obstructive pulmonary disease RECEIVED

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Syndrome d’apnées obstructives du sommeil et cognition : une revue

Cited by 27 publications

References 127 publications

Assessment of Cerebral Hypoxemia and Its Impact on Cognitive and Psychological Functions in Patients With Obstructive Sleep Apnea Syndrome

Assessment of Cerebral Hypoxemia and Its Impact on Cognitive and Psychological Functions in Patients With Obstructive Sleep Apnea Syndrome

Environmental Enrichment Protects Against Cognition Deficits Caused by Sepsis-Associated Encephalopathy

Factors influencing breath analysis results in patients with diabetes mellitus

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