Syndrome de Vogt-Koyanagi-Harada. À propos de huit cas

Alaoui, F.Z.; Benamour, S.; Kabli, H. El; Amraoui, A.

doi:10.1016/j.revmed.2006.12.009

Cited by 8 publications

(5 citation statements)

References 8 publications

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“…We failed to find any significant clinical difference in the Maghreb population, but for age and gender trends. However, we report here one of the largest case reports about Maghreb to our knowledge [ 32 – 34 ] suggesting a higher prevalence in this population. Indeed, initial clinical presentation seems more severe in this population, especially the ophthalmic presentation, even if we did not find any clinical significance [ 35 ].…”

Section: Discussionmentioning

confidence: 67%

Vogt-Koyanagi-Harada disease: a retrospective and multicentric study of 41 patients

Diallo

Revuz²,

Clavel-Refregiers

et al. 2020

BMC Ophthalmol

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Background East and South East Asian subjects as well as Amerindians and Hispanic subjects are predominantly affected by Vogt-Koyanagi-Harada disease. In Europe, only few studies have described the clinical features and treatment of this disease, especially in France. Methods This retrospective case series was based on data collected from patients with a VKH disease diagnosed from January 2000 to March 2017, provided by three French Tertiary Centers. Results Forty-one patients (16 men and 25 women) were diagnosed: average age at diagnosis was 38.7 years. Patients were mainly from Maghreb (58%), but ethnic origins were multiple. Pleiocytosis was observed in 19 cases (63%) and 17 out of 41 patients showed audio vestibular signs (41%), and 11 showed skin signs (27%). Thirty-four were treated with corticosteroids (83%), 11 with an immunosuppressant treatment (27%) and 5 with biological therapy drugs (13%). Relapse was observed in 41% patients, even though final average visual acuity had improved. We did not find any significant clinical difference in the population from Maghreb compared to other populations, but for age and sex trends, since there was a majority of younger women. Conclusion We report here the second largest French cohort reported to date to our knowledge. The multiethnicity in our study suggests that VKH disease should be evoked whatever patients’ ethnicity.

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Section: Discussionmentioning

confidence: 67%

Vogt-Koyanagi-Harada disease: a retrospective and multicentric study of 41 patients

Diallo

Revuz²,

Clavel-Refregiers

et al. 2020

BMC Ophthalmol

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“…La maladie affecte essentiellement les jeunes femmes mélanodermes. Les enfants peuvent être affectés, mais l'âge moyen du début de la maladie est plutôt de 30 ans (de 10 à 52 ans) [ 2 , 3 ]. La pathogenèse de l'affection a été reliée à un désordre immunologique dirigé contre les mélanocytes entraînant une cytotoxicité et une apoptose médiées par les lymphocytes T. Les mélanocytes étant des cellules originaires de la crête neurale et forment la peau, les méninges, la rétine, l'uvée, la cochlée et le labyrinthe et donc la maladie peut toucher ces différents organes.…”

Section: Discussionunclassified

Vitiligo révélant une maladie de Vogt-Koyanagi-Harada

Amraoui¹,

Zemmez²,

Bourazza³

et al. 2017

Pan Afr Med J

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RésuméLe vitiligo est une dermatose chronique auto-immune, souvent associé ou fait découvrir d'autres pathologies auto-immunes. Son association à une atteinte ophtalmologique à type de pan uvéite et /ou une atteinte neurologique à type de méningite et/ou de l'oreille interne à type de surdité détermine la maladie ou le syndrome de Vogt-Koyanagi-Harada (VKH). Nous rapportons le cas d'une jeune femme qui consultait pour des uvéites récidivantes depuis un an, Et ce n'était qu'avec l'apparition des lésions de vitiligo que le diagnostic de maladie de VKH a été évoqué et confirmé.

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“…VKH syndrome usually affects young adults between 30 and 40 years with a female predominance [1,2]. Its clinical manifestations is various, they evolve classically into three phases.…”

Section: Discussionmentioning

confidence: 99%

Vogt-Koyanagi-Harada syndrome associated to hypothyroidism revealed by myocarditis

Ismail¹,

Mzabi²,

Karmani³

et al. 2012

OJIM

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Purpose: Vogt-Koyanagi-Harada (VKH) syndrome is usually defined as an uveo-meningitis who may be associated with auditory and cutaneous signs. Association of VKH syndrome and autoimmune thyroiditis is uncommon. Observation: A 28-year-old man was admitted with thoracic pain due to myocarditis. Two years ago he presented VKH syndrome with specific ocular manifestation and deafness, treated by corticosteroids and immunosuppressive. Etiologic investigation of myocarditis concluded to deep hypothyroidism related to Hashimoto thyroiditis. The patient improved after substitutive treatment by thyroid hormones. Conclusion: Thyroid function should be systematically investigated in case of VKH syndrome and particularly when associated to dysthyroidism symptoms.

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Syndrome de Vogt-Koyanagi-Harada. À propos de huit cas

Cited by 8 publications

References 8 publications

Vogt-Koyanagi-Harada disease: a retrospective and multicentric study of 41 patients

Vogt-Koyanagi-Harada disease: a retrospective and multicentric study of 41 patients

Vitiligo révélant une maladie de Vogt-Koyanagi-Harada

Vogt-Koyanagi-Harada syndrome associated to hypothyroidism revealed by myocarditis

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