“…Indeed, this edema could be secondary to the permanent obstruction of the dermal lymphatics by mast cells or linked to dermal fibrosis induced by these cells [4]. Clinically, chronic erythematous asymmetric edema of the upper two thirds of the face generally affects the forehead, glabella, eyelids, nose, and cheeks, associated with telangiectasia, facial redness, papules, pustules, nodules [5]. It poses a problem of differential diagnosis mainly with chronic lupus erythematosus, Merkelson-Rosenthal syndrome in its atypical form, dermatomyositis [6].…”