Syndrome Following Abrupt Cessation of Prolonged Cortisone Therapy

Henneman, Philip H.; Wang, David M.K.; Irwin, John W.; Burrage, Walter S.

doi:10.1001/jama.1955.02960050026006

Cited by 33 publications

(5 citation statements)

References 5 publications

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“…The steroid withdrawal syndrome (Amatruda, Hurst, and D'Esopo, 1965;Henneman, Wang, Irwin, and Burrage, 1955) was not frequent in these patients. One man developed a constitutional reaction associated with a raised E.S.R.…”

Section: Incidence Of Complications In Corticosteroid-treated and Conmentioning

confidence: 66%

Incidence of serious complications of corticosteroid therapy in respiratory disease: A retrospective survey of patients in the Brompton Hospital

Smyllie

Connolly

1968

Thorax

113

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A retrospectively controlled study is described of mortality and serious morbidity in 550 patients treated with corticosteroids and 499 controls. The overall incidence of side-effects was similar in both groups, but gastro-intestinal bleeding, diabetes, and mental disturbance early in treatment occurred more frequently in the corticosteroid group. Other individual side-effects did not occur significantly more often than in the controls, but there was an overall increased frequency of complications with increased dose, and also an increased mortality with increase in the maintenance dose. Gastro-intestinal bleeding was not related to a past or present chronic peptic ulcer, and was not commoner in treated patients. Reactivation of tuberculosis and exacerbation of mental disturbance did not occur. Weight gain occurred in 29% of patients, but appeared to be related closely to a satisfactory response to treatment. Hypertension occurred in 4% of the treated group. Overall mortality in the two groups was similar. Mortality due specifically to corticosteroids was difficult to assess: two patients died of haematemesis and three died with severe asthma during withdrawal of treatment, but there was no increase in mortality following physical stress in the treated series. Sudden death in asthmatics was not more frequent in corticosteroid-treated patients. All seven control patients who died suddenly with asthma were middleaged. Increase in duration of treatment was not associated with increased risk. Indeed the longterm, low-dose group had a lower incidence of complications than the rest and a mortality similar to that of the controls. A trial of corticosteroids for less than one month carried no risk in 41 patients.

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Section: Incidence Of Complications In Corticosteroid-treated and Conmentioning

confidence: 66%

Incidence of serious complications of corticosteroid therapy in respiratory disease: A retrospective survey of patients in the Brompton Hospital

Smyllie

Connolly

1968

Thorax

113

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“…Only 2/22 patients remained completely asymptomatic after prednisone-ACTH withdrawal. 5 In a study conducted by Henneman et al, 6 19 chronic asthma patients who had been on cortisone therapy from 11 to 38 months developed symptoms lasting from one to four days within 24e48 hours after the cortisone was discontinued. In nine patients, the symptoms were either mild or did not occur; in four patients, the symptoms were moderate, and in the remaining six patients, the symptoms were severe.…”

Section: Treatment Of the Steroid Withdrawal Syndromementioning

confidence: 99%

The Steroid Withdrawal Syndrome: A Review of the Implications, Etiology, and Treatments

Margolin

Cope

Bakst-Sisser

et al. 2007

Journal of Pain and Symptom Management

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“…Henneman and associates (18), reporting on adults who have subsisted on cortisone for periods of over a year, noted that their patients began to experience a rapidly worsening headache within 24 to 48 hours after the last oral dose of the steroid. These patients also had some anorexia, vomiting, and generalized malaise.…”

Section: Palliative Medicationsmentioning

confidence: 99%

Inhalant Allergy in Children

Rapaport¹

1959

Int Arch Allergy Immunol

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Syndrome Following Abrupt Cessation of Prolonged Cortisone Therapy

Cited by 33 publications

References 5 publications

Incidence of serious complications of corticosteroid therapy in respiratory disease: A retrospective survey of patients in the Brompton Hospital

Incidence of serious complications of corticosteroid therapy in respiratory disease: A retrospective survey of patients in the Brompton Hospital

The Steroid Withdrawal Syndrome: A Review of the Implications, Etiology, and Treatments

Inhalant Allergy in Children

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