Syndrome néphrotique idiopathique corticodépendant de l’enfant : facteurs prédictifs de recours à un traitement immunosuppresseur

Golay, M; Douillard, Aymeric; Nagot, Nicolas; Fila, Marc; Ichay, L.; Vale, F. Dalla; Tenenbaum, J.; Morin, Denis

doi:10.1016/j.arcped.2017.08.013

Archives de Pédiatrie

2017

DOI: 10.1016/j.arcped.2017.08.013

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Syndrome néphrotique idiopathique corticodépendant de l’enfant : facteurs prédictifs de recours à un traitement immunosuppresseur

M Golay

Aymeric Douillard²,

Nicolas Nagot³

et al.

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Cited by 2 publications

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Development of hormone dependence in children with hormone-sensitive nephrotic syndrome at the onset of the disease

Nyrkova

Савенкова

2022

Ross. vestn. perinatol. pediatr.

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Objective. To identify the features of the development of hormone dependence in children with hormone-sensitive nephrotic syndrome at the onset of the disease.Characteristics of children and research methods. The authors carried out a retro- and prospective study with age assessment at the onset of the disease and first relapse in 118 children with hormone-sensitive nephrotic syndrome at the onset with a rarely and often recurrent course.Results. The authors revealed a rarely and often recurrent course in 118 children with hormone-sensitive nephrotic syndrome at the onset of the disease, respectively, in 51 and 49% of cases with the development of hormone dependence (64%) and without (36%). They found statistically significant differences: the age of children at the onset of nephrotic syndrome, who developed hormone dependence and who did not develop, was 3.4 [2.2; 4.8] and 4.2 [3.0; 5.6] years accordingly (p<0.05); the age of children with nephrotic syndrome who developed hormone dependence and who did not develop hormone dependence by first relapse, was 3.8 [2.6; 5.1] and 5.7 [4.0; 7.4] years accordingly (p<0.001). The duration of the period until the first relapse after the onset in children with nephrotic syndrome, who developed hormone dependence and who did not develop hormone dependence, was 4 [4; 5] and 11 [7; 17] months, respectively (p<0.00001). Hormone dependence was revealed in 75 and 47% patients, respectively (p<0.05) among children with nephrotic syndrome who had the first relapse before 5 years of age and after 5 years of age.Conclusion. The age of children at the onset and the first relapse of nephrotic syndrome, which developed hormone dependence, is significantly less than those without hormone dependence. Children with nephrotic syndrome who have had their first relapse before 5 years of age were more likely to become hormone-dependent.

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Development of hormone dependence in children with hormone-sensitive nephrotic syndrome at the onset of the disease

Nyrkova

Савенкова

2022

Ross. vestn. perinatol. pediatr.

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A child with newly diagnosed kidney disease and his family: determination of early factors of disease progression and features of nephroprotection

Makovetskaya

Poretskova

Mazur

et al. 2023

Ross. vestn. perinatol. pediatr.

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Chronic kidney disease and a decrease in its progression is a global health problem. However, the risk factors associated with the primary nosology of glomerular diseases of children have not been sufficiently studied.Purpose. To determine early risk factors for the progression of chronic kidney disease for more effective prevention of chronization of the process, based on the analysis of clinical and anamnestic data, the features of the manifestation of the primary developed glomerular pathology, and taking into account nosological forms.Material and methods. The experience of own clinical observations, retro- and prospective, related to the formation of chronic kidney disease of children with glomerular pathology is summarized. The study was conducted on the basis of the children’s uronephrological center of the Samara Regional Clinical Hospital named after V.D. Seredavin.Results. The universal risk factors are systematized: transferred critical conditions in the perinatal period with the development of acute kidney injury; prenatally established CAKUT syndrome; the presence of a genetic predisposition to kidney diseases, a complex of allergic diseases in the family; the carriage of persistent infections, hemolytic strains of streptococcus, social determinant, environmental conditions, etc. Specific early risk factors for disease progression, features of the onset of kidney pathology and biomarkers of progression that determine early kidney damage have been identified. The features of nephroprotection are formulated: interdisciplinarity with the inclusion of organizational, social components; operational communication with the outpatient link; the use of social networks for educational processes — the patient’s family, training of first-contact doctors.

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Syndrome néphrotique idiopathique corticodépendant de l’enfant : facteurs prédictifs de recours à un traitement immunosuppresseur

Cited by 2 publications

References 22 publications

Development of hormone dependence in children with hormone-sensitive nephrotic syndrome at the onset of the disease

Development of hormone dependence in children with hormone-sensitive nephrotic syndrome at the onset of the disease

A child with newly diagnosed kidney disease and his family: determination of early factors of disease progression and features of nephroprotection

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