Syndrome of acute idiopathic ophthalmoplegia with ataxia and areflexia

Elizan, Teresita S.; Spire, J. P.; Andiman, R. M.; Baughman, F. A.; Lloyd-Smith, Donald

doi:10.1212/wnl.21.3.281

Cited by 54 publications

(24 citation statements)

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“…In our study, the results of those patients who had brain CT or MRI examinations with or without contrast enhancement were all within normal limits. As in our patients, most of the cases reported [9, 19, 20, 31, 43]did not have respiratory failure, and survived without significant morbidity, although Blau et al [44]reported 2 patients who developed respiratory failure during the illness.…”

Section: Discussionsupporting

confidence: 66%

Miller Fisher Syndrome: A Hospital-Based Retrospective Study

Yuan

Wang²,

Tsai³

2000

Eur Neurol

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Miller Fisher syndrome (MFS), characterized as ataxia, areflexia and ophthalmoplegia, is generally considered as a variant of Guillain-Barré syndrome (GBS). However, some investigators believed that the syndrome could be explained by a central origin. To obtain more information about MFS for comparison with GBS, we conducted a retrospective study by analyzing the clinical data of MFS patients admitted to our hospital over a period of 11 years. The calibrated male/female ratio was 1.65. A seasonal clustering in winter was noted. The percentage of MFS among GBS was especially high (18%, 11/60) in Taiwan when compared with other series. Involvement of limb muscle strength, autonomic function and cranial nerves, except ocular motor nerves, was rarely found in our patients. When MFS is accompanied by limb weakness, it might represent a transitional form between MFS and GBS. Bulbar palsy and dysautonomia might predict a relatively poor prognosis. To obtain more reliable information, lumbar puncture should be done 1 week after disease onset, and electrophysiological tests should be done serially in every MFS patient. Eighty percent (80%, 4/5) of our patients were positive for IgG anti-GQ_1b antibody activity. In our study, there is more evidence indicating that MFS is a peripheral nervous system disorder; however, no definite conclusion could be made as to whether MFS is exclusively a peripheral or central nervous system disorder. We think MFS is an immune-mediated clinical entity which mainly involves the peripheral nervous system with rare involvement of other parts of the central nervous system.

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Section: Discussionsupporting

confidence: 66%

Miller Fisher Syndrome: A Hospital-Based Retrospective Study

Yuan

Wang²,

Tsai³

2000

Eur Neurol

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“…We found only 14 cases of recurrence [6][7][8][9][10][11][12][13][14][15][16][17][18] (including incomplete forms) in the literature. In addi tion, what drew our attention was the laterality of the cranial nerve findings.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Fisher’s Syndrome with Immunological Abnormalities and Replicated Laterality

Uchihara

Ikeda²,

Tsukagoshi³

1991

Eur Neurol

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A case of Fisher’s syndrome which recurred 10 years apart was reported. Laterality of cranial nerve findings in the initial episode was replicated in the recurrence. Some kind of localized immune sensitization is supposed to play a role in replicating such a laterality. Increased CD4/CD8 ratio and elevated IgE were noted, which suggests immunological behavior in Fisher’s syndrome similar to that in Guillain-Barré syndrome.

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“…N a fase inicial o olhar conjugado para baixo e a convergência são normais e o acometimento é maior nos movimentos do olhar para cima e lateral 3 , como no presente caso. Embora as lesões sejam sugestivas de alterações supranucleares e do tronco cerebral não se encontram substratos anátomo-patológico nestes locais que as justifiquem 3,4,5,7. São admitidas lesões periféricas dos nervos oculares e que possam ocorrer alterações dos mecanismos intramedulares 3 > 4 > 9 .…”

Section: Examesunclassified

Sindrome de Miller Fisher: relato de um caso

Scaff

Marchiori

Callegaro

et al. 1982

Arq. Neuro-Psiquiatr.

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Os autores relatam caso de um paciente de 34 anos de idade, sexo masculino com oftalmoplegia externa, ataxia severa, distúrbio de marcha, apalestesia e discreta alteração da sensibilidade superficial nas palmas das mãos e plantas dos pés. A força muscular era normal. Este quadro se iniciou no 15º dia após contrair infecção de vias aéreas superiores de provável causa viral. O paciente foi tratado com ACTH melhorando rapidamente.

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Syndrome of acute idiopathic ophthalmoplegia with ataxia and areflexia

Cited by 54 publications

References 0 publications

Miller Fisher Syndrome: A Hospital-Based Retrospective Study

Miller Fisher Syndrome: A Hospital-Based Retrospective Study

Recurrent Fisher’s Syndrome with Immunological Abnormalities and Replicated Laterality

Sindrome de Miller Fisher: relato de um caso

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