Syndrome of continuous muscle fiber activity and plasmacytoma with IgM paraproteinemia

Abstract

A patient with IgM-lambda plasmacytoma presented with continuous muscle fiber activity syndrome (CMFAS), which responded to carbamazepine therapy. This is the first report of CMFAS in association with plasmacytoma and IgM paraproteinemia.

Neuromyotonia, systemic lupus erythematosus and acetylcholine-receptor antibodies

“…Garcia-Merino et al [5] consider this syndrome as a paraneoplastic manifestation of a malignant tumour; recently there has been increasing interest in the hypotheses that consider the paraneoplastic syndromes to be the result of an autoimmune process towards shared antigens of the nervous system and of neoplastic cells. From the analysis of the data that have appeared in the literature in the last decade, an involvement of immunological mechanisms in NMT is inferred, since in 13 of the 17 described cases serum autoantibodies were found [2,5,7,8,13,16,17,20,21,26], and a good response to plasmapheresis was also reported [21]. Concerning the specificity of these autoantibodies, the most frequent ones are the anti-AChR Abs, which were found in 9 of 19 cases (including ours).…”

“…NMT has been described in association with peripheral neuropathies [5,6,14,17,25], plexopathies secondary to radiotherapy [1], lung neoplasm [24], thymoma [5,7,17] myasthenia gravis [5,7,17] and plasmocytoma [26].…”

Paraneoplastic syndromes of the spinal cord, nerve, and muscle

“…90 One patient with thymoma developed neuromyotonia, MG, and limbic encephalitis. 66 Other associated tumors may include Hodgkin's lymphoma, 25 bronchial carcinoma, 245 SCLC, 185 plasmacytoma with IgM paraproteinemia, 259 and a mediastinal tumor, probably lung cancer. 247 Neuromyotonia may improve spontaneously, or with phenytoin, carbamazepine, and plasma exchange.…”

Childhood onset of acquired neuromyotonia: Association with a ganglioneuroma

“…Common cancers linked to acquired NMT in adults include small‐cell carcinoma of the lung and thymoma . Single cases of bladder and ovarian cancer, Hodgkin lymphoma, plasmacytoma with IgM paraproteinemia, lymphoplasmacytic lymphoma, and hemangioblastoma have been reported.…”