Syndrome of inappropriate anti-diuresis induces volume-dependent hypercalciuria

Grellier, Jimmy; Jaafar, A.; Martin, Alexandre; Alaoui, Meddy El; Lebely, Claire; Tack, Ivan; Vallet, Marion

doi:10.1007/s00198-017-4186-x

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…In a single study on hyponatremia secondary to SIADH, the levels of 1–250 H vitamin D and of PTH were reported to be normal [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…High calciuria has been reported in hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) [ 11 , 12 ]. This has been attributed to the increase in the effective vascular volume [ 11 , 12 ]. This high calciuria could contribute to osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

“…In SIADH, the increase in effective volemia will decrease the tubular resorption of sodium at different levels of the renal tubules and this will contribute to the increase in calciuria (particularly in the proximal tubule [ 17 , 18 ]). In a previous study on hypercalciuria in SIADH, there were only two patients reported where daily calcium excretion was reported after correction of SNa [ 11 ] and one in another study [ 12 ]. In the present report, we discuss the calciuria of a large population of patients with chronic hyponatremia of different origins.…”

Section: Introductionmentioning

confidence: 99%

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The Urine Calcium/Creatinine Ratio and Uricemia during Hyponatremia of Different Origins: Clinical Implications

Decaux

Musch²

2023

JCM

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Background: Chronic hyponatremia is known to be associated with osteoporosis. It has been shown that chronic hyponatremia increases bone resorption in an attempt to release body stores of exchangeable sodium by different mechanisms. We wanted to know the calciuria of patients with hyponatremia of different origins. Material and Methods: We made a retrospective study of 114 consecutive patients with asymptomatic hyponatremia of different origins with the usual serum and urine chemistry. Result: In hyponatremia due to SIADH, we had a high urine calcium/creatinine ratio of 0.23 ± 0.096 while in patients with salt depletion the UCa/UCr ratio was low (0.056 ± 0.038), in patients with hyponatremia secondary to thiazide intake the value was also low (0.075 ± 0.047) as in hypervolemic patients (0.034 ± 0.01). In hyponatremia due to polydipsia, the value was high (0.205 ± 0.10). Correction of hyponatremia in the euvolemic patients was associated with a significant decrease in the UCa/UCr ratio. In patients with hyponatremia secondary to thiazide intake, we noted that in the patients with low uric acid levels (<4 mg/dL, suggesting euvolemia) we also observed a low UCa/UCr (<0.10). In nine patients with chronic SIADH (SNa 125.1 ± 3.6 mEq/L), the 24 h urine calcium excretion was 275 ± 112 mg and decreased to 122 ± 77 mg (p < 0.01) after at least 2 weeks of treatment. Conclusions: Patients with chronic hyponatremia due to SIADH usually have a high UCa/UCr ratio (>0.15). This is also observed in hyponatremia secondary to polydipsia. Patients with thiazide-induced hyponatremia usually have low UCa/UCr levels and this is the case even among those with a biochemistry similar to that in SIADH (uric acid < 4 mg/dL).

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“…In a single study on hyponatremia secondary to SIADH, the levels of 1–250 H vitamin D and of PTH were reported to be normal [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Urine Calcium/Creatinine Ratio and Uricemia during Hyponatremia of Different Origins: Clinical Implications

Decaux

Musch²

2023

JCM

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Quels paramètres biologiques pour estimer le statut volémique ?

Vallet

Jaafar

Charles

et al. 2018

Néphrologie & Thérapeutique

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Sodium loading, treadmill walking, and the acute redistribution of bone mineral content on dual energy X-ray absorptiometry scans

Hew‐Butler

Angelakos

Szczepanski

2019

American Journal of Physiology-Regulatory, Integrative and Comp

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The purpose of this study was to assess relationships between plasma sodium concentration ([Na+]) and bone mineral content (BMC) after an acute sodium load plus treadmill walking and then quantify the amount of sodium the dual energy X-ray absorptiometry (DXA) scan could detect. The primary study was a single-blind randomized control crossover trial under two conditions: ingestion of six flour tablets (placebo trial) or six 1-g NaCl tablets (salt intervention trial). The tablets were ingested after baseline blood and urine collection followed immediately by the DXA scan. After 60 min of rest, a 45-min treadmill walk was conducted. Immediately postexercise, blood and urine were collected and the DXA scan was repeated. Main outcomes included changes (∆: post minus pre) in plasma [Na+] and BMC. Additionally, six 1-g NaCl tablets were superimposed over a DXA spine phantom for separate quantification of sodium as BMC. Fourteen subjects completed the primary study. Two-way repeated measures ANOVA tests revealed significant interaction ( F = 13.06; P = 0.0007), condition ( F = 21.88; P < 0.001), and time ( F = 6.51; P = 0.014) effects in plasma [Na+]. A significant condition ( F = 6.46; P = 0.014) effect was also noted in urine [Na+]. Total body BMC∆ was negatively correlated with plasma [Na+]∆ ( r = −0.43; P = 0.02) and urine [Na+]∆ ( r = −0.47; P = 0.01). Total body BMC∆ in the salt intervention trial [−5.5 (27) g] closely approximated the amount of NaCl ingested and subsequently absorbed into the bloodstream. The DXA scan quantified 67% of NaCl tablets as BMC in spine phantom analyses. Total body BMC∆ was negatively related to plasma and urine [Na+]∆ after treadmill walking. Reductions in total body BMC closely approximated the amount of NaCl ingested (~6 g). The DXA scan quantified NaCl as BMC.

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Syndrome of inappropriate anti-diuresis induces volume-dependent hypercalciuria

Cited by 4 publications

References 44 publications

The Urine Calcium/Creatinine Ratio and Uricemia during Hyponatremia of Different Origins: Clinical Implications

The Urine Calcium/Creatinine Ratio and Uricemia during Hyponatremia of Different Origins: Clinical Implications

Quels paramètres biologiques pour estimer le statut volémique ?

Sodium loading, treadmill walking, and the acute redistribution of bone mineral content on dual energy X-ray absorptiometry scans

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