Syndrome of inappropriate antidiuretic hormone secretion secondary to trauma in a dog

Cilli, Nicole M.; Bellis, Tara

doi:10.1111/vec.13143

Cited by 3 publications

(2 citation statements)

References 25 publications

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“…5 There is limited evidence of SIADH associated with TBI in veterinary medicine, including 1 published report of SIADH secondary to trauma. 9 However, despite a search of the published literature, there are no veterinary reports of CSWS, and to our knowledge this is the first report describing suspected CSWS in a dog.…”

Section: Introductionmentioning

confidence: 85%

“…While development of SIADH is not specific to TBI and can result from neoplasia, nonmalignant lung disease, certain drugs including opioids, and neurologic disorders, 5 CSWS has only been associated with primary intracranial disease 5 . There is limited evidence of SIADH associated with TBI in veterinary medicine, including 1 published report of SIADH secondary to trauma 9 . However, despite a search of the published literature, there are no veterinary reports of CSWS, and to our knowledge this is the first report describing suspected CSWS in a dog.…”

Section: Introductionmentioning

confidence: 99%

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Suspected cerebral salt wasting syndrome secondary to traumatic brain injury in a dog

Chromiak,

Finstad,

Cooper

2024

J Vet Emergen Crit Care

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ObjectiveTo describe a dog with suspected cerebral salt wasting syndrome (CSWS) secondary to traumatic brain injury (TBI).Case SummaryA 2‐month‐old intact male Chihuahua‐American Pitbull Terrier mix weighing 1.94 kg presented to a veterinary teaching emergency room after suffering bite wound‐penetrating trauma to the head. Treatment was initiated with hyperosmotic agents, fluid resuscitation, and analgesia. The dog's neurologic dysfunction warranted hospitalization and continuous monitoring. Within 24 hours, the dog developed hyponatremia (133 mmol/L compared to 143 mmol/L on presentation [reference interval 142–149 mmol/L]). As the dog had concurrent tachycardia, increase in urine sodium concentration, polyuria, and weight loss, a diagnosis of cerebral salt wasting was suspected. A 2% hypertonic saline constant rate infusion was administered for volume replacement, and the patient showed improvement in clinical signs and blood sodium concentration. The dog was discharged on Day 5. Recheck examination showed significant neurologic improvement with sodium just below the low end of the reference range (141 mmol/L [reference interval 142–149 mmol/L]).New or Unique Information ProvidedThis is the first description of suspected CSWS in veterinary medicine. Hyponatremia is a common finding in critically ill neurologic people, including those with TBI, and is typically associated with either syndrome of inappropriate antidiuretic hormone or CSWS. As treatment recommendations for syndrome of inappropriate antidiuretic hormone and CSWS are diametrically opposed, identifying the presence of hyponatremia and distinguishing between these 2 clinical entities is critical for improving patient care for those with TBI. This case highlights the characteristics and clinical progression regarding the diagnosis and management of suspected CSWS.

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Section: Introductionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Suspected cerebral salt wasting syndrome secondary to traumatic brain injury in a dog

Chromiak,

Finstad,

Cooper

2024

J Vet Emergen Crit Care

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Suspected paraneoplastic syndrome of inappropriate antidiuretic hormone secretion associated with a gastric adenocarcinoma in a dog

Thomas,

Finlay,

Sharp

2024

Aust Veterinary J

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This report describes a suspected case of paraneoplastic syndrome of inappropriate antidiuretic hormone (SIADH) in a 5‐year‐old male entire Australian Kelpie associated with a gastric adenocarcinoma. The dog had a history of chronic vomiting and presented with hyponatraemia, hypokalaemia, hypochloraemia and increased urinary sodium. Computed tomography identified the presence of a gastric tumour and histopathology confirmed a pyloric gastric adenocarcinoma. Removal of the tumour via a Billroth I procedure resulted in rapid resolution of electrolyte derangements. The dog was still alive six months postoperatively with no recurrence of either SIADH or tumour at the time of publication.

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Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion

Adin,

Levinzon,

Harris

2024

Journal of the American Animal Hospital Association

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An approximately 3 yr old female Chihuahua was presented for evaluation of polyuria and polydipsia noted by the owner after adoption. Serum biochemistry and urinalysis revealed hyponatremia, hypochloremia, hypo-osmolality, and normal fractional excretion of sodium. Serum antidiuretic hormone concentration was 5.54 pg/mL and serum copeptin concentration was 135.40 pg/mL. The antidiuretic hormone value was above the reported range for healthy dogs and was considered inappropriate in light of serum osmolality. Idiopathic syndrome of inappropriate antidiuretic hormone secretion was considered the most likely diagnosis after excluding other potential causes, such as diuretic use, renal disease, adrenal disease, and thyroid dysfunction. The dog remains clinically well 2 yr after diagnosis without specific treatment other than minimal dietary salt supplementation. This case is unique because of the absence of systemic or neurologic signs, good long-term outcome without treatment, and use of novel diagnostic testing.

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Syndrome of inappropriate antidiuretic hormone secretion secondary to trauma in a dog

Cited by 3 publications

References 25 publications

Suspected cerebral salt wasting syndrome secondary to traumatic brain injury in a dog

Suspected cerebral salt wasting syndrome secondary to traumatic brain injury in a dog

Suspected paraneoplastic syndrome of inappropriate antidiuretic hormone secretion associated with a gastric adenocarcinoma in a dog

Long-term Outcome of a Chihuahua With Idiopathic Syndrome of Inappropriate Antidiuretic Hormone Secretion

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