Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx

Abstract

A patient with a primary undifferentiated carcinoma of the nasopharynx manifested the clinical syndrome of inappropriate antidiuretic hormone secretion (SIADH). Immunohistochemical techniques demonstrated the presence of vasopressin, neurophysin, and their precursor (propressophysin) in the cancer cells. In situ hybridization additionally confirmed the expression of propressophysin messenger RNA in these cells. To the knowledge of the authors, this represents not only the first case of SIADH caused by carcinoma of the nasopharynx, but also the first report of pathologic confirmation of the syndrome with the use of both molecular and immunologic probes. Cancer 1992; 69:1315‐1319.

Syndrome of Inappropriate ADH Secretion (SIADH) During Chemotherapy with Carboplatin/Paclitaxel for Metastatic Fallopian Tube Cancer

“…However, ADH serum levels in our patient remained within the normal limits. Normal ADH serum levels sometimes imply a hypothalamic origin of paraneoplastic ADH secretion [5], or a direct ADH-synthesis and release from neoplastic cells [7,8]. Therefore, we performed additional immunhistochemistry which did not reveal neuroendocrine differentiation in our patient's tumor, as immunhistochemical testing of NSE, Chromogranin, ADH, ANP was negative.…”

SIADH Induced by Pharyngeal Squamous Cell Carcinoma: Case Report and Literature Review

“…However, they were unable to explain the mechanism behind it. Although researchers have found AVP gene in small cell and undifferentiated carcinoma, they have failed to find AVP gene in squamous cell carcinoma [7]. In 2004, Lee proposed that neuropeptide Y is increased in squamous cell carcinoma patients which in turn increases endogenous AVP production leading to SIADH [8].…”

Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Secretion Caused by Squamous Cell Carcinoma of the Nasopharynx: Case Report

“…Although many researchers have found AVP gene not only in small cell carcinoma but also in undifferentiated carcinoma (8) and anaplastic carcinoma (9), they have failed to find AVP gene in squamous cell carcinoma. However, some neuropeptides related to AVP have been detected in squamous cell carcinoma.…”