Syndrome of intraabdominal hypertension: pathophysiological aspects and surgical problems

Aliyev, Shamil; Алиев, Э. С.; Sadykzade, T. B.; Kerimov, M. M.; Tagiev, E G

doi:10.26779/2522-1396.2020.1-2.86

Cited by 2 publications

(1 citation statement)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Нарушения регионарного кровообращения и циркуляции в мелких сосудах приводят к недостаточному снабжению кислородом и энергетическими субстратами энтероцитов. Развивается вторичная тканевая гипоксия и ацидоз, страдают метаболические процессы на всех уровнях, в клетке происходят необратимые изменения [40]. Высокое внутрибрюшное давление -важный фактор в развитии панкреонекроза, приводящий к специфическим осложнениям [41].…”

unclassified

Modern Ideas on the Role of Hemodynamic Disorders in the Pathogenesis of Acute Pancreatitis

Midlenko,

Chavga

et al. 2023

Ulyanovsk Medico-biological Journal

View full text Add to dashboard Cite

Acute pancreatitis remains one of the most common abdominal diseases, causing a large number of both local and systemic complications. Acute pancreatitis has a high death rate. The pathogenesis of acute pancreatitis is complex and needs careful examination. Many authors suppose, that hemodynamic disorders lead to the development of complications, often fatal. Thus, such disorders need be studied separately. The review is based on the analysis of articles included in such databases as elibrary.ru, cyberleninka.ru, and e-versions of specialized open access journals. All the articles outline modern views on the role of hemodynamic disorders in the pathogenesis of acute pancreatitis. The causes and mechanisms of development of hemodynamic disorders are considered in terms of central and regional hemodynamics, and microcirculation. The authors describe their mutual influence and role in the development of both local and systemic complications of acute pancreatitis. Contractility disorders can be observed in the pathogenesis of central hemodynamics. They can be caused by a highly active myocardial depressant factor. These disorders are supported and aggravated by other organs and systems with the development of multiple organ failure. Violations of regional hemodynamics are associated mainly with an increase in intra-abdominal pressure. A direct dependence of intestinal wall perfusion on intra-abdominal pressure is established. Intestinal barrier dysfunction contributes to the infection of necrosis foci. Microcirculation disorders are the most important element in the pathogenesis of acute pancreatitis, often defining its outcome. Microcirculation disorders include angiospasm, venous stasis, microthrombi formation, and interstitial edema. A decrease in local perfusion due to impaired gland microcirculation can cause tissue ischemia and pancreonecrosis.

show abstract

unclassified

Modern Ideas on the Role of Hemodynamic Disorders in the Pathogenesis of Acute Pancreatitis

Midlenko,

Chavga

et al. 2023

Ulyanovsk Medico-biological Journal

View full text Add to dashboard Cite

show abstract

Correction of hepatorenal syndrome with the use method of indirect electrochemical detoxification in oncological patients on the background of enteral insufficiency after multi-organic surgeries

Pavliuchenko

Krutko

Matvieienko

et al. 2022

The Journal of v. N. Karazin Kharkiv National University, Series "Medicine"

View full text Add to dashboard Cite

Introduction. Enteral insufficiency syndrome accompanies the development of many acute diseases of the abdominal cavity. According to statistics, as a result of advanced and multi-organ surgery in oncosurgery for 2019–2020, enteral insufficiency was a complication in 39 % of all cases, regardless of anatomical and physiological area, and complications such as hepatorenal syndrome – in 50–80 % cases. The aim of the work is to study the effectiveness of correction of hepatorenal syndrome on the background of enteral insufficiency in cancer patients after multiorgan surgery. To do this, we used the method of indirect electrochemical detoxification with a solution of sodium hypochlorite. Materials and methods. 71 patients with oncopathology who underwent multiorgan surgery in different anatomical and physiological areas were examined. Patients were divided into two groups: the main group (n = 36), in which indirect electrochemical detoxification was performed with sodium hypochlorite solution at a concentration of 0.03 ; the comparison group (n = 35) – treatment was carried out according to standard schemes. The groups were compared by age and anatomical and physiological areas that were operated on (surgery was performed on the chest and mediastinum and abdominal organs). Results and discussion. For the treatment of patients with enteral insufficiency used the method of electrochemical detoxification with sodium hypochlorite, which reduces the indicators that reflect blood toxicity and the degree of intoxication. This was evidenced by a decrease in the concentration of bilirubin by 23.1 %, urea by 20.6 %, creatinine by 23.4 %, ALT by 57.2 % alkaline phosphatase by 69.5 %. When using this method for the third day managed to get a detoxifying effect. Conclusions. The expediency of including sodium hypochlorite in the complex postoperative therapy is shown. This is proved by the results of a comprehensive study of cancer patients after multiorgan surgery with the development of hepatorenal syndrome on the background of enteral insufficiency. It was found that the use of infusions of 0.03 % NaClO solution has a detoxifying effect: significantly reduces elevated concentrations of bilirubin by 23.1 %, creatinine by 20.6 %, urea by 23.4 %, improves the rheological properties of the blood. Therefore, given the relatively low effectiveness of conservative and insufficient availability of surgical treatment along with high mortality, prevention of hepatorenal syndrome in patients with enteral insufficiency by indirect electrochemical detoxification can significantly reduce its incidence.

show abstract

Syndrome of intraabdominal hypertension: pathophysiological aspects and surgical problems

Abstract: Syndrome of intraabdominal hypertension: pathophysiological aspects and surgical problems

Cited by 2 publications

References 42 publications

Modern Ideas on the Role of Hemodynamic Disorders in the Pathogenesis of Acute Pancreatitis

Modern Ideas on the Role of Hemodynamic Disorders in the Pathogenesis of Acute Pancreatitis

Correction of hepatorenal syndrome with the use method of indirect electrochemical detoxification in oncological patients on the background of enteral insufficiency after multi-organic surgeries

Contact Info

Product

Resources

About